A5074155206- Nanoplatforms for cancer theranostics
- Luminescence Properties of Advanced Materials
- Laser-Ablation Synthesis of Nanoparticles
- Nanoparticle-Based Drug Delivery
- Lanthanide and Transition Metal Complexes
- Advanced Nanomaterials in Catalysis
- Bone Tissue Engineering Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Diamond and Carbon-based Materials Research
- Carbon and Quantum Dots Applications
- Luminescence and Fluorescent Materials
- Radiation Detection and Scintillator Technologies
- Adsorption and biosorption for pollutant removal
- Synthesis and biological activity
- Analytical chemistry methods development
- Calcium Carbonate Crystallization and Inhibition
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Electrospun Nanofibers in Biomedical Applications
- Sulfur Compounds in Biology
- Nanomaterials for catalytic reactions
- Cancer, Lipids, and Metabolism
- Petroleum Processing and Analysis
Guangzhou Medical University
2015-2025
Stomatology Hospital
2020-2021
Third Affiliated Hospital of Guangzhou Medical University
2021
Tianjin University of Technology
2018-2020
Chongqing Cancer Hospital
2018
Chongqing University
2018
Sun Yat-sen University Cancer Center
2012-2016
Sun Yat-sen University
2012-2016
Guangzhou Experimental Station
2014
Sichuan Agricultural University
2013
Mn-based nanoparticles (NPs) have emerged as new class of probes for magnetic resonance imaging due to the impressive contrast ability. However, reported NPs possess low relaxivity and there are no immunotoxicity data regarding agents. Here, we demonstrate ultrahigh water protons 8.26 mM(-1) s(-1) from Mn3O4 synthesized by a simple green technique, which is twice higher than that commercial gadolinium (Gd)-based agents (4.11 s(-1)) highest value date NPs. We first time these...
Abstract An abnormal trap distribution and coordination geometry‐dependent multi‐band emission are discovered in chromium‐doped aluminates. The broadband persistent luminescence from 650–1100 nm peaking at 688 793 Cr 3+ ‐doped SrAl 12 O 19 is systematically studied via structural spectroscopic analysis. Solid state nuclear magnetic resonance allows the visualization of various configurations , thus offering possibility tailoring local geometry center to trigger control spectral parameter....
Background: Understanding the biocompatibility and biointeractions of nano-carbon quantum dots (nano-CQDs) in vitro vivo is important for assessing their potential risk to human health. In previous research, physical properties CQDs synthesized by laser ablation liquid (LAL) method were analyzed detail; however, possible bioapplications not considered. Materials Methods: prepared LAL characterized atomic force microscopy, fluorescence lifetime, absorption spectrum, Fourier-transform infrared...
Monoclinic Gd2O3:Eu3+ nanoparticles (NPs) possess favorable magnetic and optical properties for biomedical application. However, how to obtain small enough NPs still remains a challenge. Here we combined the standard solid-state reaction with laser ablation in liquids (LAL) technique fabricate sub-10 nm monoclinic explained their formation mechanism. The obtained exhibit bright red fluorescence emission can be successfully used as probe cells imaging. In vitro vivo resonance imaging (MRI)...
Abstract The aim of this study was to isolate hydrocarbons-degrading bacteria for treatment oily wastewater from long-standing petroleum-polluted sediments in Bohai Bay, China. Six were screened and identified as Pseudomonas sp. Bacillus A new approach using a combination various bacterial species petroleum biodegradation proposed evaluated its degradation characteristics. Gas chromatography-flame ionization detection (GC-FID) analysis showed that mixed agents (YJ01) degraded 80.64% crude...
We have demonstrated that nanodiamonds (NDs), as oxidation and reduction catalysts, possess intrinsic enzyme mimetic properties of oxidase, peroxidase catalase, these behaviors can be switched by modulating the pH value.
Hydrogen sulfide releasing agents (or H2S donors) have been recognized gasotransmitters with potent cytoprotective and anticancer properties. However, the clinical application of donors has hampered by their fast H2S-release, instability, lack tumor targeting, despite unclear molecular mechanism action. Here we rationally designed an amphiphilic pentapeptide (RGDFF) to coassemble de novo thiol-activated (CL2/3) into nanocarriers for targeted therapy non-small-cell lung cancer, which proved...
Gadolinium oxide (Gd2O3), which can be used as a T1-weighted magnetic resonance imaging (MRI) contrast agent, has attracted intense attention in recent years. In this paper, ligand-free monoclinic Gd2O3 nanocrystals of 7.1 nm diameter are synthesized by simple and green approach, namely microsecond laser ablation gadolinium (Gd) target deionized water. These obtain high r1 relaxivity 5.53 s(-1) mM(-1), their low toxicity was demonstrated the cell viability S18 cells apoptosis RAW264.7 cells....
Abstract: The development of upconversion nanoparticles (UCNs) for theranostics application is a new strategy toward the accurate diagnosis and efficient treatment cancer. Here, magnetic fluorescent lanthanide-doped gadolinium oxide (Gd 2 O 3 ) UCNs with bright luminescence (UCL) high longitudinal relaxivity ( r 1 are used simultaneous resonance imaging (MRI)/UCL dual-modal photodynamic therapy (PDT). In vitro in vivo MRI studies show that these products can serve as good contrast agents....
Dualmodal contrast agents of rare earth doped gadolinium oxide (Gd2O3) nanoparticles with high spatial resolution for magnetic resonance imaging (MRI) and sensitivity fluorescence have attracted intensive attention in biomedical imaging. However, the mentioned above been so far synthesized by hydrothermal method, which is a bottom-up requiring purity chemical reagents relying on availability respective precursors strict reaction conditions. Here, we propose facile environmentally friendly...
Abstract: We investigated the tracking potential of a magnetic resonance imaging (MRI) probe made gadolinium-doped mesoporous silica MCM-41 (Gd 2 O 3 @MCM-41) nanoparticles for transplanted bone mesenchymal stem cells (MSCs) and neural (NSCs) in vivo. The nanoparticles, synthesized using one-step synthetic method, possess hexagonal structures with appropriate assembly nanoscale Gd clusters. They show little cytotoxicity against proliferation have lower effect on inherent differentiation...
Nonsmall cell lung cancer (NSCLC), which accounts for the majority of cancer-related deaths globally, remains refractory to available therapies despite advancements in treatment modalities. Hence, there is a pressing need development safer and more efficacious combination therapeutic strategies. Barbiturate derivatives have emerged as promising candidates chemotherapy. In this study, we introduced JL1-MOF/PNIPAM (JMP), nanomedicine platform that encapsulates JL1, barbituric acid derivative,...
Ultra-small gadolinium oxide (Gd2O3) can be used as T1-weighted Magnetic Resonance Imaging (MRI) contrast agent own to its high longitudinal relaxivity (r1) and has attracted intensive attention in these years. In this paper, ultra-small Gd2O3 nanoparticles of 3.8 nm diameter have been successfully synthesized by a microsecond laser ablating (Gd) target diethylene glycol (DEG). The growth inhibition effect induced the large viscosity DEG makes it possible synthesize ablation DEG. r1 value MR...
Abstract: Poor toxicity characterization is one obstacle to the clinical deployment of Gd 2 O 3 @SiO core-shell nanoparticles (Gd-NPs) for use as magnetic resonance (MR) imaging contrast agents. To date, there no systematic data available Gd-NPs prepared by laser ablation in liquid. In this article, we systematically studied Gd-NPs' cytotoxicity, apoptosis vitro, immunotoxicity, blood circulation half-life, biodistribution and excretion vivo, well pharmacodynamics. The results show toxicity,...
In photothermal treatments (PTTs), normal tissues around cancerous tumors get injured by excessive heat, whereas damaged cancer cells are easily restored stress-induced heat shock proteins (HSPs) at low temperatures. Therefore, to achieve a unique tumor microenvironment (TME), it is imperative increase PTT efficiency and reduce tissue injury adopting appropriate reactive oxygen species (ROS) lipid peroxides (LPO) cross-linked with HSPs. the present research, potential strategy for mild...