A5016657481- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Advanced Nanomaterials in Catalysis
- Viral Infections and Vectors
- Thermal properties of materials
- RNA Interference and Gene Delivery
- Microtubule and mitosis dynamics
- Nanopore and Nanochannel Transport Studies
- Machine Learning and ELM
Griffith University
2016-2019
Most of the current exosome-analysis strategies are time-consuming and largely dependent on commercial extraction kit-based preisolation step, which requires extensive sample manipulations, costly isolation kits, reagents, tedious procedures, sophisticated equipment is prone to bias/artifacts. Herein we introduce a simple method for direct subsequent detection specific population exosomes using an engineered superparamagnetic material with multifunctional properties, namely, gold-loaded...
Tumor-derived exosomes have emerged as promising cancer biomarkers due to their unique composition and functions. Herein, we report a stripping voltammetric immunoassay for the electrochemical detection of disease-specific using quantum dots signal amplifiers. The assay involves three subsequent steps where bulk exosome populations are initially magnetically captured on magnetic beads by generic tetraspanin antibody (e.g., CD9 or CD63) followed identification cancer-related. Here, used CdSe...
A sensitive and amplification-free assay for the electrochemical detection of exosomal miRNAs in complex biological samples.
Abstract Exosomes are cell‐derived vesicles secreted by both normal and cancerous cells into the extracellular matrix in blood circulation. Tumor‐derived exosomes have attracted increasing attention noninvasive cancer diagnosis prognosis. However, their effective capture specific detection pose significant technical challenges. Current methods largely fail to quantify tumor‐derived present total (bulk) exosome population derived from body fluids of patients. In this proof‐of‐concept study,...
Cellular response to mechanical stimuli is an integral part of cell homeostasis. The interaction the extracellular matrix with stress plays important role in cytoskeleton organisation and alignment. Insights from can be utilised develop culture methods that achieve predefined patterns, which are critical for tissue remodelling therapy. We report working principle, design, simulation, characterisation a novel electromagnetic stretching platform based on double-sided axial approach. device...
Cellular response to mechanical stimuli is an integral part of cell homeostasis. The interaction the extracellular matrix with stress plays important role in cytoskeleton organisation and alignment. Insights from can be utilised develop culture methods that achieve predefined patterns, which are critical for tissue remodelling therapy. We report working principle, design, simulation characterisation a novel electromagnetic stretching platform based on double-sided axial approach. device...