A5006738993- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- MicroRNA in disease regulation
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Aquaculture disease management and microbiota
- Antimicrobial Peptides and Activities
- Ferroptosis and cancer prognosis
- Additive Manufacturing Materials and Processes
- Genomics, phytochemicals, and oxidative stress
- Physiological and biochemical adaptations
- High Entropy Alloys Studies
- Additive Manufacturing and 3D Printing Technologies
- Advanced Proteomics Techniques and Applications
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- Immune cells in cancer
- Circular RNAs in diseases
- Metabolomics and Mass Spectrometry Studies
- Cancer Genomics and Diagnostics
- Aquaculture Nutrition and Growth
- Cancer, Lipids, and Metabolism
Guangdong 999 Brain Hospital
2025
South China Normal University
2025
Johns Hopkins University
2023-2025
Chengdu University of Traditional Chinese Medicine
2025
Capital Medical University
2024
Hunan Normal University
2014-2024
Northeast Normal University
2023-2024
Chengdu Third People's Hospital
2024
Beijing Anzhen Hospital
2024
Chengdu Medical College
2024
// Hao Bo 1,2,3 , Zhaojian Gong 2,4 Wenling Zhang 2 Xiayu Li 3 Yong Zeng 1 Qianjin Liao Pan Chen Lei Shi 4 Yu Lian Yizhou Jing Ke Tang Zheng Yanhong Zhou Ming Xiang Xiaoling Jianbo Yang 1,5 Wei Xiong Guiyuan and Zhaoyang Hunan Cancer Hospital The Affiliated of Xiangya School Medicine, Central South University, Changsha, Hunan, China Key Laboratory Carcinogenesis the Chinese Ministry Health Invasion Education, Research Institute, Nonresolving Inflammation Cancer, Disease Genome Center, Third...
Recent studies have revealed that long non-coding RNAs participate in all steps of cancer initiation and progression by regulating protein-coding genes at the epigenetic, transcriptional, post-transcriptional levels. Long are turn regulated other genes, forming a complex regulatory network. The regulation networks between p53 tumor suppressor these nasopharyngeal carcinoma remains unclear. aims this study were to investigate roles TP53 gene RNA expression profiles function TP53-regulated...
// Qijia Yan 1,2,3 , Zhaoyang Zeng Zhaojian Gong 2,4 Wenling Zhang 2 Xiayu Li 3 Baoyu He Yali Song Qiao Yong 1 Qianjin Liao Pan Chen Lei Shi 4 Songqing Fan Bo Xiang Jian Ma Ming Zhou Xiaoling Jianbo Yang 1,5 Wei Xiong and Guiyuan Hunan Key Laboratory of Translational Radiation Oncology, Cancer Hospital The Affiliated Xiangya School Medicine, Central South University, Changsha, Hunan, China Carcinogenesis the Chinese Ministry Health Invasion Education, Research Institute, Nonresolving...
Clear cell sarcoma of the kidney (CCSK), second most common renal tumor in children, poses significant diagnostic challenges. No positive markers are available, and pathogenesis CCSK remains an enigma. To address these challenges, gene expression patterns 14 CCSKs were compared with 15 Wilms tumors 3 fetal samples using oligonucleotide arrays.Using unsupervised methods, profile was distinctive: differentially expressed genes could largely be grouped into four categories: (a) a wide variety...
Abstract BACKGROUND Rice sheath blight is a globally important rice disease. Unfortunately, this critical disease has not been effectively controlled, and the intensive continuous use of same fungicide might increase risk resistance development in pathogen. To discover new active agents against blight, study, three series β ‐carboline urea, benzoylurea benzoylthiourea derivatives were designed, synthesized evaluated for vitro vivo fungicidal activity Rhizoctonia solani . RESULTS All these...
Menopause is one of the crucial physiological events during life a woman. Transition menopause status accompanied by increased risks various health problems such as osteoporosis. Peripheral blood monocytes can differentiate into osteoclasts and produce cytokines important for osteoclast activity. With quantitative proteomics LC-nano-ESI-MS(E) (where MS(E) elevated-energy MS), we performed protein expression profiling peripheral in 42 postmenopausal women with discordant bone mineral density...
Mounting evidence suggests that immune cell infiltration within the tumor microenvironment (TME) is a crucial regulator of carcinogenesis and therapeutic efficacy in ovarian cancer (OC). In this study, 593 OC patients from TCGA were divided into high low score groups based on their immune/stromal scores resulting analysis utilizing ESTIMATE algorithm. Differential expression revealed 294 intersecting genes influencing both stromal scores. Further Cox regression identified 34 differentially...
In a continuing effort to develop novel β-carbolines endowed with better insecticidal activity, simple high-yielding method for the synthesis of harmine compounds starting from L-tryptophan has been developed and series 1,3-substituted β-carboline derivatives have synthesized evaluated their cytotoxicity against insect cultured Sf9 cell line in vitro activities 4th instar larvae mosquitos, Culex pipiens quinquefasciatus mustard aphid, Lipaphis erysimi. The results demonstrated that...
The upregulation of tribbles homolog 3 (TRB3), a pseudokinase in mammals, has been observed several types malignant cancer, including thyroid, ovarian, liver and colorectal cancer. However, the pathological role regulatory mechanism TRB3 cancer remain unknown. In current study, we demonstrated that expression was upregulated non-small cell lung (NSCLC), correlating with tumor metastasis, disease recurrence poor survival patients. Knocking down aggressive lines to significantly inhibit their...
ABSTRACT Astrocytes, the most prevalent type of glial cells, have been found to play a crucial part in numerous physiological functions. By offering metabolic and structural support, astrocytes are vital for proper functioning brain regulating information processing synaptic transmission. Astrocytes located medial prefrontal cortex (mPFC) highly responsive environmental changes associated with development disorders. One primary mechanisms through which responds factors is epitranscriptome...
Abstract Background This study aimed to determine factors associated with patient portal accessing of sexually transmitted infection (STI) test results among adolescents and young adults (AYA) at a large urban hospital. Methods We analyzed 12-month retrospective electronic health record (EHR) data 15,396 patients aged 15 25 who received STI testing. Multinomial logistic regression measured relationships characteristics results, (defined as the time from when were released portal, AYA logged...
Small nucleolus RNA Host Gene 8 (SNHG8) belongs to a subgroup with long non-coding RNAs. LncRNA SNHG8 presents up-regulated in miscellaneous cancers, like gastric cancer, liver and esophageal squamous cell cancer. Nevertheless, the expression pattern pathological function of lncRNA breast cancer remain obscure.We examined levels tissue samples lines from via RT-qPCR present study. The functions on progression were by CCK-8, EdU, Transwell chamber assays, flow cytometry analyses. proteins was...
The pathogenic gene CDH23 plays a pivotal role in tip links, which is indispensable for mechanoelectrical transduction the hair cells. However, underlying molecular mechanism and signal regulatory networks that influence deafness still largely unknown.In this study, congenital family, whole exome sequencing revealed new mutation CDH23, subsequently; has been validated using Sanger method. Then CRISPR/Cas9 technology was employed to knockout zebrafish cdh23 gene. Startle response experiment...