A5101872680- Pancreatic and Hepatic Oncology Research
- Tuberculosis Research and Epidemiology
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mycobacterium research and diagnosis
- Conducting polymers and applications
- Cancer Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Food Safety and Hygiene
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Fuel Cells and Related Materials
- Gastroesophageal reflux and treatments
- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Cancer Immunotherapy and Biomarkers
- Electrocatalysts for Energy Conversion
- Chronic Obstructive Pulmonary Disease (COPD) Research
- ICT Impact and Policies
- Perovskite Materials and Applications
- Esophageal and GI Pathology
- Immune Cell Function and Interaction
- Medical Imaging and Pathology Studies
- Neuroblastoma Research and Treatments
- Ginseng Biological Effects and Applications
- Pancreatitis Pathology and Treatment
Yonsei University
2015-2025
Ewha Womans University
2023-2025
Kyung Hee University
2024
Severance Hospital
2023
Konkuk University
2023
Seoul National University Hospital
2017-2022
Gachon University
2015-2020
Gachon University Gil Medical Center
2014-2019
Deleted Institution
2019
Korea Advanced Institute of Science and Technology
2019
Dissolving microneedle (DMN), a transdermal drug delivery system in which drugs are encapsulated biodegradable polymeric microstructure, is designed to dissolve after skin penetration and release the into body. However, because of limited loading capacity within microsized structures, only small dosage can be delivered, often insufficient for patients. We propose novel DMN application that combines topical simultaneously improve permeation efficiency. Drugs pretreated formulation patch...
Summary Background For effective skin depigmentation, the depigmentation agent must be delivered to melanocytes, where melanin is synthesized. Although dissolving microneedle ( DMN ) one of best transdermal drug delivery systems deliver active compound, no clinical trial has been conducted in terms safety and efficacy. Objectives To assess efficacy a patch that contained 4‐n‐butylresorcinol, agent. Methods In assessment, 31 subjects were selected for primary irritation test using Frosch...
Identification of vaccine target antigens (Ags) that induce Ag-specific Th1 immunity is the first step toward development a tuberculosis vaccine. Here, we evaluated Mycobacterium (Mtb) protein Rv3628, soluble inorganic pyrophosphatase, as and characterized molecular details its interaction with dendritic cells (DCs). Rv3628 activated DCs, increasing their expression cell surface molecules augmenting production TNF-α, IL-1β, IL-6, IL-12p70. mediated these effects by binding to TLR2 activating...
A better understanding of the kinetics accumulated immune cells that are involved in pathophysiology during Mycobacterium tuberculosis (Mtb) infection may help to facilitate development vaccines and immunological interventions. However, innate adaptive associated with pathogenesis Mtb their relationship virulence not clearly understood. In this study, we used a mouse model compare bacterial burden, inflammation aerogenic lung between laboratory-adapted strains (Mtb H37Rv H37Ra) K strain,...
BACKGROUNDIncreasing levels of antibiotic resistance have reduced the Helicobacter pylori (H.pylori) eradication rates afforded by standard triple therapy.Thus, 2-wk firstline four-drug regimens must be considered. AIMTo analyze modified bismuth-containing quadruple therapy (mBCQT) and concomitant (CT), associated adverse events, compliance.KCT0001821.
Background: [68Ga]-DOTATOC PET/CT is a valuable technique for identifying neuroendocrine tumors overexpressing somatostatin receptors; however, its diagnostic and prognostic utility WHO low-grade pancreatic remains unclear. Therefore, we aimed to evaluate uptake in well-differentiated determine predictive capability metastasis. Methods: Patients with pathologically diagnosed well-differentiated, non-functional who underwent between 2015 2021 were included. Medical records indices (maximal...
Recent studies have demonstrated the therapeutic potential of mesenchymal stem cells (MSCs) for treatment acute inflammatory injury and bacterial pneumonia, but their applications in mycobacterial infections not been investigated. In this study, we use MSCs as a novel strategy against Mycobacterium abscessus (M. abscessus), which is most drug-resistant difficult-to-treat pathogen. The systemic intravenous injection only improved mouse survival also enhanced clearance lungs spleen....
Ginsenosides are the principal active components of ginseng and considered attractive candidates for combination cancer therapy because they can kill tumors have favorable safety profiles. However, overall benefit ginsenosides remains unclear, particularly in immunosurveillance, considering controversial results showing repression or promotion immune responses. Here we identify a potentiating role ginsenoside F1 (G-F1) surveillance by natural killer (NK) cells. Among 15 different...
The incidence of postendoscopic retrograde cholangiopancreatography (ERCP) infections is reported to be up 18% in patients with biliary obstruction. Antibiotic prophylaxis may reduce the risk infectious complications after ERCP; however, clinical value prophylactic antibiotics ERCP remains controversial.
Although Mycobacterium abscessus (M. abscessus) is becoming more prevalent in patients without overt immunodeficiency, little known about the factors that contribute to disease susceptibility. This study was undertaken investigate how Toll-like receptor 2 (TLR2) functionally contributes generation of protective immunity against M. a morphotype-specific manner. We found Tlr2-/- mice were extremely susceptible an intravenous (i.v.) model infection by rough variants, displaying uncontrolled...
To develop a highly efficient solar cell using organometal halide perovskites, its microscale structure control is one of the most important factors because microstructural defects inside perovskite are harmful to charge carrier flow and, thus, degrade device performance. In this study, we confirmed existence large physical gaps at grain boundary in methylammonium iodide (MAPbI3, MA = CH3NH3) with transmission electron microscopy (TEM) analysis and revealed that gap prevents MAPbI3...
Given the persistent occurrence of foodborne illnesses linked to both raw and processed vegetables, understanding microbial behavior in these foods under distribution conditions is crucial. This study aimed develop predictive growth models for Salmonella spp. Listeria monocytogenes (mung bean sprouts, onion, cabbage) vegetables (shredded cabbage salad, onion juices) at various temperatures, ranging from 4 36 °C. Growth were constructed validated using isolated strains (S. Bareilly, S....
While extreme sleep duration negatively affects mortality and health-related quality of life (HRQOL) in general populations, the relationship remains uncertain patients with chronic obstructive pulmonary disease (COPD).To evaluate association between HRQOL COPD.We analyzed 3,349 participants COPD enrolled 2007-2015 Korea National Health Nutrition Examination Survey (KNHANES). Participants aged 40 years or older a smoking history prebronchodilator forced expiratory volume 1 s/forced vital...
Moon-Jin Jeong, Myoung-Hwa Lee, Soon-Jeong So-Jeong Kim, Myeong-Ji Ko, Hye-Won Sim, Ju-Young Ae-Jung Im, and Do-Seon Lim. J Dent Hyg Sci 2019;19:261-70. https://doi.org/10.17135/jdhs.2019.19.4.261