A5056816726- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Cerebral Palsy and Movement Disorders
- Genetic Neurodegenerative Diseases
- Stroke Rehabilitation and Recovery
- Balance, Gait, and Falls Prevention
- Nerve Injury and Rehabilitation
- Transcranial Magnetic Stimulation Studies
- Cancer Treatment and Pharmacology
- Muscle activation and electromyography studies
- Pain Mechanisms and Treatments
- Effects of Vibration on Health
- Motor Control and Adaptation
- Parkinson's Disease and Spinal Disorders
- Functional Brain Connectivity Studies
- Cardiovascular Syncope and Autonomic Disorders
- Hereditary Neurological Disorders
- Neuroscience and Music Perception
- Pain Management and Treatment
- Assistive Technology in Communication and Mobility
- Cancer-related molecular mechanisms research
- Genomic variations and chromosomal abnormalities
- Neural dynamics and brain function
- Acupuncture Treatment Research Studies
Don Carlo Gnocchi Foundation
2016-2025
University of the Sacred Heart
2024
John Wiley & Sons (United States)
2021-2023
University of Milan
2014-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2011-2021
Università Cattolica del Sacro Cuore
2019
Fondazione IRCCS Istituto Neurologico Carlo Besta
2012-2014
Ospedale Maggiore
2014
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2014
Istituti Clinici di Perfezionamento
2014
Gait analysis is recognized as a useful assessment tool in the field of human movement research. However, doubts remain on its real effectiveness clinical tool, i.e. capability to change diagnostic-therapeutic practice. In particular, conditions which evidence favorable cost-benefit ratio found and methodology for properly conducting interpreting exam are not identified clearly. To provide guidelines use Analysis context rehabilitation medicine, SIAMOC (the Italian Society Clinical Movement...
Although the 6-Minute Walk Test (6MWT) is among recommended clinical tools to assess gait impairments in individuals with Parkinson’s disease (PD), its standard outcome consists only of distance walked 6 min. Integrating a single Inertial Measurement Unit (IMU) could provide additional quantitative and objective information about quality complementing outcome. This study aims evaluate test–retest reliability, validity discriminant ability parameters obtained by IMU during 6MWT subjects mild...
PURPOSE: Unilateral cerebral palsy (UCP) represents about 30–40% of overall diagnoses. Upper limb impairment has a significant negative impact on activities daily living (ADL), and recent studies have shown that the use virtual reality (VR) can increase motivation promote an improvement in ADL. This preliminary study was aimed at exploring acceptability usability VR rehabilitation treatment, using VITAMIN Platform, for children with UCP. A secondary goal to compare results usual standardized...
Abstract Telerehabilitation is emerging as a promising digital method for delivering rehabilitation to Parkinson’s Disease (PD) patients, especially in the early stages promote brain resilience. This study explores how cognitive reserve (CR), brain’s ability withstand aging and disease, impacts effectiveness of telerehabilitation. It specifically examines influence lifelong activities on relationship between neural improved functional abilities following rehabilitation. In study, 42 PD...
Parkin disease (PARK2, OMIM 602544) is an autosomal-recessive early-onset parkinsonism characterized by early occurrence of lower limb dystonia. The aim this study was to analyze spatiotemporal, kinematic, and kinetic gait parameters in patients with parkin the OFF ON conditions compared healthy age-matched controls.Fifteen 15 controls were studied a analysis laboratory integrated optoelectronic system. Spatiotemporal, at self-selected speed recorded conditions. A jerk index computed...
Background Several earlier studies showed a female predominance in idiopathic adult-onset dystonia (IAOD) affecting the craniocervical area and male preponderance limb dystonia. However, sex-related differences may result from bias inherent to study design. Moreover, information is lacking on whether exist expressing other dystonia-associated features spread. Objective To provide accurate relationship between sex differences, motor phenomenology, natural history of IAOD. Methods Data 1701...
This perspective article addresses the critical and up-to-date problem of task-specific musician’s dystonia (MD) from both theoretical practical perspectives. Theoretically, MD is explored as a result impaired sensorimotor interplay across different brain circuits, supported by most frequently cited scientific evidence—each referenced dozens times in Scopus. Practically, significant issue it occurs over 60 more musicians compared to other professions, underscoring influence individual...
Abstract Smoothness (i.e. non-intermittency) of movement is a clinically important property the voluntary with accuracy and proper speed. Resting head position movements are impaired in cervical dystonia. The current work aims to evaluate if smoothness rotations reduced this disease. Twenty-six dystonia patients 26 controls completed rightward leftward rotations. Patients’ were differentiated into “towards-dystonia” (rotation accentuated torticollis) “away-dystonia”. was quantified by...
The effect of lidocaine pretreatment on thermal hyperalgesia and skin asymmetries provoked by experimental mononeuropathy was investigated in rats. Forty anesthetized rats were given sciatic nerve ligatures according to the technique Bennett Xie. Rats divided into 3 groups: 16 ligated without lidocaine, after bathing nerve, 8 systemic (6–8 mg/kg). Six sham-operated for each group also prepared. From first postoperative day responses hot-plate test assessed daily 4 weeks tracking paw-licking...
The effect of intravenous lidocaine (4 mg kg-1) on ganglionic and spinal neuronal hyperactivity following sciatic chronic constriction injury (CCI) was studied in anaesthetized curarized rats. A significant difference the time course magnitude two populations found. Longer lasting more potent inhibitory effects dorsal horn neurones comparison with were observed. By contrast highly comparable before after acute rhizotomy. results indicate that peripheral central are not sequentially related....
To test the hypothesis that adult-onset primary dystonia may be underlying etiology of tremulous patients with clinical diagnosis Parkinson disease (PD) but without evidence dopaminergic deficit at nigrostriatal SPECT imaging.We retrospectively reviewed and imaging data PD assessed our tertiary movement disorder clinic, who underwent dopamine transporter consecutively between 2002 2011. Molecular screening for DYT1, DYT5, DYT6, DYT11, DYT16 genes was performed in all cases met following...
Gait analysis has demonstrated to efficaciously support clinical investigations. The patterns of the outcome variables (joint angles, moments and powers) are characterized by an intrinsic extrinsic variability. Particularly, variability is induced operator-dependent differences in markers’ placement, with errors propagating non-linearly alter variable patterns. aims this study (1) consider a specific gait protocol named LAMB provide description its procedures, (2) experimentally assess...
Maintaining a stable gait requires dynamic balance control, that can be altered in persons with Multiple Sclerosis (MS), Stroke (ST), and Parkinson's disease (PD). The understanding of the strategy for Center Mass (CoM) positioning adopted by patients during walking is important to able program treatments aimed at improving control preventing falls. Forty-four mild-to-moderate neurological disorder (20 MS, 14 ST, 10 PD) underwent clinical examination analysis. Ten Healthy Subjects (HS)...
This analysis pooled pain severity data from four phase 3 and 4 studies of incobotulinumtoxinA (incoBoNT-A) for the treatment cervical dystonia (CD) in adults. CD-related was assessed at baseline, each injection visit, weeks after incoBoNT-A using Toronto Western Spasmodic Torticollis Rating Scale subscale or a visual analog scale. Both were analyzed score range 0–10 categorized as mild, moderate, severe. Data 678 patients with baseline sensitivity analyses evaluated responses subgroup not...