A5060571448- Mosquito-borne diseases and control
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- Insect symbiosis and bacterial influences
- Zoonotic diseases and public health
- COVID-19 Pandemic Impacts
- Virology and Viral Diseases
- COVID-19 Clinical Research Studies
- Dengue and Mosquito Control Research
- Viral Infections and Outbreaks Research
- SARS-CoV-2 detection and testing
- COVID-19 impact on air quality
- Insect and Pesticide Research
- Influenza Virus Research Studies
- Hepatitis Viruses Studies and Epidemiology
- Long-Term Effects of COVID-19
- Insect and Arachnid Ecology and Behavior
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
University of Florida
2016-2025
World Health Organization
2022-2025
James Cook University
2020-2021
Australian Institute of Tropical Health and Medicine
2020-2021
University of Hawaiʻi at Mānoa
2020
Florida College
2018-2019
Industrial University of Santander
2015
We use a data-driven global stochastic epidemic model to analyze the spread of Zika virus (ZIKV) in Americas. The has high spatial and temporal resolution integrates real-world demographic, human mobility, socioeconomic, temperature, vector density data. estimate that first introduction ZIKV Brazil likely occurred between August 2013 April 2014 (90% credible interval). provide simulated profiles incident infections for several countries Americas through February 2017. is characterized by...
Abstract Arboviruses transmitted mainly by Aedes ( Stegomyia ) aegypti and Ae. albopictus , including dengue, chikungunya, Zika viruses, yellow fever virus in urban settings, pose an escalating global threat. Existing risk maps, often hampered surveillance biases, may underestimate or misrepresent the true distribution of these diseases do not incorporate epidemiological similarities despite shared vector species. We address this generating new environmental suitability maps for -borne...
Abstract Objective Since the 1980s, dengue incidence has increased 30‐fold. However, in 2017, there was a noticeable reduction reported cases within Americas, including severe and fatal cases. Understanding mechanism underlying dengue's decline Americas is vital for public health planning. We aimed to provide plausible explanations 2017. Methods An expert panel of representatives from scientific academic institutions, Ministry Health officials Latin America PAHO/WHO staff met October 2017...
Abstract In 2015 and 2016, Zika virus (ZIKV) swept through dengue (DENV) endemic areas of Latin America. These viruses are the same family, share a vector may interact competitively or synergistically human immune responses. We examine incidence from Brazil Colombia before, during, after epidemic. find evidence that was atypically low in 2017 both countries. investigate whether subnational is associated with changes mixed results. Using simulations multiple assumptions interactions between...
Background Historically, mosquito control programs successfully helped contain malaria and yellow fever, but recent efforts have been unable to halt the spread of dengue, chikungunya, or Zika, all transmitted by Aedes mosquitoes. Using a dengue transmission model results from indoor residual spraying (IRS) field experiments, we investigated how IRS-like campaign scenarios could effectively in an endemic setting. Methods findings In our model, found that high levels household coverage (75%...
Transmission of Zika virus (ZIKV) was first detected in Colombia September 2015. As April 2016, had reported over 65,000 cases disease (ZVD). We analysed daily surveillance data ZVD to the health authorities San Andres and Girardot, Colombia, between 2015 January 2016. laboratory-confirmed by reverse transcription-polymerase chain reaction (RT-PCR) serum acute within five days symptom onset. use incidence estimate basic reproductive number (R0) each population. identified 928 1,936 from...
Dengue vaccines will soon provide a new tool for reducing dengue disease, but the effectiveness of widespread vaccination campaigns has not yet been determined. We developed an agent-based model representing movement and transmission dynamics among people mosquitoes in Yucatán, Mexico, simulated various vaccine scenarios to evaluate under those conditions. This includes detailed spatial representation Yucatán population, including location 1.8 million between 375,000 households 100,000...
Abstract The understanding of immunological interactions among the four dengue virus (DENV) serotypes and their epidemiological implications is often hampered by lack individual-level infection history. Using a statistical framework that infers full history, we analyze prospective pediatric cohort in Nicaragua to characterize how history modulates risks DENV subsequent clinical disease. After controlling for age, one prior associated with 54% lower, while two or more are 91% higher, risk new...
Viruses transmitted by Aedes mosquitoes, such as dengue, Zika, and chikungunya, have expanding ranges seem unabated current vector control programs. Effective of these pathogens likely requires integrated approaches. We evaluated dengue management options in an endemic setting that combine novel vaccination using agent-based model for Yucatán, Mexico, fit to 37 y data. Our intervention models are informed targeted indoor residual spraying (TIRS) experiments; trial outcomes World Health...
Chikungunya virus (CHIKV) a mosquito-borne alphavirus is the causative agent of (CHIK), disease with low mortality but high acute and chronic morbidity resulting in overall burden disease. After phase, including persistent arthralgia very common, can cause fatigue pain that severe enough to limit normal activities. On average, around 40% people infected CHIKV will develop arthritis, which may last for months or years. Recommendations protection from focus on infection control through...
Abstract Background Accurate seroprevalence estimates of SARS-CoV-2 in different populations could clarify the extent to which current testing strategies are identifying all active infection, and hence true magnitude spread infection. Our primary objective was identify valid studies infection compare their with reported, imputed, COVID-19 case rates within same population at time point. Methods We searched PubMed, Embase, Cochrane trials, Europe-PMC for published pre-prints that reported...
Global risk maps are an important tool for assessing the global threat of mosquito and tick-transmitted arboviral diseases. Public health officials increasingly rely on to understand drivers transmission, forecast spread, identify gaps in surveillance, estimate disease burden, target evaluate impact interventions. Here, we describe how current approaches mapping diseases have become unnecessarily siloed, ignoring strengths weaknesses different data types methods. This places limits model...
Abstract Arboviral infections such as dengue, Zika and chikungunya are fast spreading diseases that pose significant health problems globally. In order to control these infections, an intracellular bacterium called Wolbachia has been introduced into wild-type mosquito populations in the hopes of replacing vector transmitting agent, Aedes aegypti with one is incapable transmission. this study, we developed a transmission model for novel w Au strain which possesses several favourable traits...
Dengue is the most prevalent mosquito-borne viral disease of humans and caused by four serotypes dengue virus. To estimate incidence other arboviruses, we analyzed baseline first year follow-up a prospective school-based cohort study their families in three cities state Yucatan, Mexico. Through enhanced surveillance activities, acute febrile illnesses participants were detected yearly blood samples collected to evaluate infection incidence. A Cox model was fitted identify hazard ratios...
Abstract We use a data-driven global stochastic epidemic model to project past and future spread of the Zika virus (ZIKV) in Americas. The has high spatial temporal resolution, integrates real-world demographic, human mobility, socioeconomic, temperature, vector density data. estimate that first introduction ZIKV Brazil likely occurred between August 2013 April 2014 (90% credible interval). provide simulated profiles incident infections for several countries Americas through February 2017....