A5055296320- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Fungal and yeast genetics research
- Yeasts and Rust Fungi Studies
- Fermentation and Sensory Analysis
- Animal Disease Management and Epidemiology
- Health disparities and outcomes
- Vector-Borne Animal Diseases
- Genomics and Phylogenetic Studies
- Nutritional Studies and Diet
- Animal Behavior and Welfare Studies
- Toxoplasma gondii Research Studies
- Pregnancy and preeclampsia studies
- Microbial Metabolic Engineering and Bioproduction
- Milk Quality and Mastitis in Dairy Cows
- Smoking Behavior and Cessation
- Food Safety and Hygiene
- Cancer-related Molecular Pathways
- Bacteriophages and microbial interactions
- Microtubule and mitosis dynamics
- Viral Infections and Vectors
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Psychosocial Factors Impacting Youth
University College Dublin
2016-2025
University of Nottingham
2015
Queen's Medical Centre
2015
Significance The highly diverse Ascomycete yeasts have enormous biotechnological potential. Collectively, these convert a broad range of substrates into useful compounds, such as ethanol, lipids, and vitamins, can grow in extremes temperature, salinity, pH. We compared 29 yeast genomes with the goal correlating genetics to traits. In one rare species, we discovered genetic code that translates CUG codons alanine rather than canonical leucine. Genome comparison enabled correlation genes...
We investigated genomic diversity of a yeast species that is both an opportunistic pathogen and important industrial yeast. Under the name Candida krusei, it responsible for about 2% infections caused by in humans. Bloodstream with C. krusei are problematic because most isolates fluconazole-resistant. names Pichia kudriavzevii, Issatchenkia orientalis glycerinogenes, same yeast, including genetically modified strains, used industrial-scale production glycerol succinate. It also to make some...
Cell-cycle progression and cell division in eukaryotes are governed part by the cyclin family their regulation of cyclin-dependent kinases (CDKs). Cyclins very well characterised model systems such as yeast human cells, but surprisingly little is known about number role Plasmodium, unicellular protozoan parasite that causes malaria. Malaria proliferation differs from many eukaryotes. During its life cycle it undergoes two types mitosis: endomitosis asexual stages an extremely rapid mitotic...
Abstract Illumina sequencing has revolutionized yeast genomics, with prices for commercial draft genome now below $200. The popular SPAdes assembler makes it simple to generate a de novo assembly any species. However, whereas making assemblies become routine, understanding what they contain is still challenging. Here, we show how graphing the information that provides about length and coverage of each scaffold can be used investigate nature an assembly, diagnose possible problems. Scaffolds...
Abstract Objectives The associations between individual lifestyle behaviours and well‐being are still poorly understood, particularly in the antenatal period when women exposed to physiological changes increased psychological distress. A healthy score (HLS) comprising protective may be useful for studying links overall psychosocial outcomes. This study aimed examine bidirectional a HLS its components pregnant with overweight/obesity. Design Secondary analyses of data from PEARS trial....
OBJECTIVES Investigate associations of different family healthy lifestyle scores (HLS) during the first 1000 days with childhood overweight and obesity (OWOB). METHODS Cohort-specific analyses were conducted on participants (n = 25 006) from 4 European birth cohorts (The study pre- early postnatal determinants child health development [EDEN], Elfe, France; Generation R, Netherlands; Lifeways, Ireland). Three composite HLSs calculated: a maternal pregnancy HLS based prepregnancy body mass...
BackgroundA high prevalence of excess weight in children younger than 5 years suggests the involvement early-life risk factors. The preconception and pregnancy periods are crucial stages for implementation interventions to prevent childhood obesity. Most studies so far have evaluated effects factors separately, with only a few investigating combined effect parental lifestyle Our objective was fill literature gap regarding study their association overweight after age years.MethodsWe...
High prevalence of overweight and obesity already observed in preschool children suggests the involvement early-life risk factors. Preconception period pregnancy are crucial windows for implementation child prevention interventions with parental lifestyle factors as relevant targets. So far, most studies have evaluated their role separately, only a few having investigated potential synergistic effect on childhood obesity. Our objective was to investigate patterns preconception periods...
The influence of maternal lifestyle behaviours on placental growth have been investigated individually, but with conflicting results, and their combined effect is under-researched. Therefore, we examined associations between a composite healthy score (HLS), its individual components, during early pregnancy outcomes.Participants included Lifeways Cross-Generational Cohort mother-child pairs (n = 202). A HLS based less inflammatory diet (bottom 40% the energy-adjusted Dietary Inflammatory...
Maternal healthy lifestyle behaviors during pregnancy have been associated with reduced risk of offspring overweight and obesity (OWOB). However, there has little investigation, in the context Paternal Origins Health Disease (POHaD) paradigm, potential influence paternal on OWOB.
Childhood represents a critical period of nutritional risk in the programming later chronic disease. Few longitudinal studies have explored repeated measures nutrition throughout first decade life relation to preteen cardiometabolic outcomes.
ABSTRACT The yeast family Pichiaceae, also known as the ‘methylotrophs clade’, is a relatively little studied group of yeasts despite its economic and clinical relevance. To explore genome evolution synteny relationships within this family, we developed Methylotroph Gene Order Browser (MGOB, http://mgob.ucd.ie) similar to our previous gene order browsers for other families. dataset contains sequences from nine Pichiaceae species, including recent reference sequence Pichia kudriavzevii. As an...
In the last decade and a half, emerging vector-borne diseases have become substantial threat to cattle across Europe. To mitigate impact of emergence new diseases, outbreaks must be detected early. However, clinical signs associated with many may nonspecific. Furthermore, there is often delay in development diagnostic tests for novel pathogens which limits ability detect disease initial stages. Syndromic Surveillance has been proposed as an additional surveillance method that could augment...
St Vincent's University Hospital (SVUH) has a comprehensive smoking management programme and since 1997 conducted periodic surveys of inpatients, outpatients, staff visitors to establish prevalence associated attitudes towards the hospital's smoke-free campus policy pioneered in 2009. We report trends describe also online community stop course (SSC) developed more recently response COVID-19. A questionnaire examining status was administered by census quota or random sub-sample staff, with...
Maternal social disadvantage adversely affects maternal and offspring health, with limited research on placental outcomes. Therefore, we examined sociodemographic factor associations birth outcomes in general (Lifeways Cross-Generation Cohort) at-risk (PEARS Study of mothers overweight or obesity) populations pregnant women. TwoStep cluster analysis profiled Lifeways (n = 250) based their age, parity, marital status, household income, private healthcare insurance, homeowner education....
Abstract Illumina sequencing has revolutionized yeast genomics, with prices for commercial draft genome now below $200. The popular SPAdes assembler makes it simple to generate a de novo assembly any species. However, whereas making assemblies become routine, understanding what they contain is still challenging. Here, we show how graphing the information that provides about length and coverage of each scaffold can be used investigate nature an assembly, diagnose possible problems. Scaffolds...
In the last decade and a half, emerging vector-borne diseases have become substantial threat to cattle across Europe. To mitigate impact of emergence new diseases, outbreaks must be detected early. However, clinical signs associated with many may nonspecific. Furthermore, there is often delay in development diagnostic tests for novel pathogens which limits ability detect disease initial stages. Syndromic Surveillance has been proposed as an additional surveillance method that could augment...