A5101486984- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Tuberculosis Research and Epidemiology
- COVID-19 diagnosis using AI
- Liver Disease Diagnosis and Treatment
- Rangeland Management and Livestock Ecology
- Plant Ecology and Soil Science
- Anesthesia and Pain Management
- Immune cells in cancer
- interferon and immune responses
- Ecology and Vegetation Dynamics Studies
- Computational Drug Discovery Methods
- Caveolin-1 and cellular processes
- Noise Effects and Management
- Diagnosis and treatment of tuberculosis
- Hepatitis C virus research
- Metabolism, Diabetes, and Cancer
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Pasture and Agricultural Systems
- Traditional Chinese Medicine Studies
- Botany and Plant Ecology Studies
- Lipid metabolism and disorders
- Plant Molecular Biology Research
- Power Systems Fault Detection
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Jilin University
2012-2025
The First Hospital of Changsha
2020-2024
Central South University
2016-2024
Guangxi Medical University
2019-2023
Chengdu University of Technology
2023
Ningbo University
2021
Shanxi Agricultural University
2021
Wuhan Children's Hospital
2020
Huazhong University of Science and Technology
2018-2020
The recent outbreak of the coronavirus disease-2019 (COVID-19) caused serious challenges to human society in China and across world. COVID-19 induced pneumonia hosts carried a highly inter-person contagiousness. patients may carry severe symptoms, some them even die major organ failures. This study utilized machine learning algorithms build severeness detection model. Support vector (SVM) demonstrated promising accuracy after 32 features were detected be significantly associated with...
Nanomedicines are highly promising for cancer therapy due to their minimal side effects. However, little is known regarding host immune response, which may limit clinical efficacy and applications. Here, we find that cisplatin (CDDP)-loaded poly(l-glutamic acid)-graft-methoxy poly(ethylene glycol) complex nanoparticles (CDDP-NPs) elicit a strong antitumor CD8+ T cell-mediated response in tumor-bearing mouse model compared free CDDP. Mechanistically, the sustained retention of CDDP-NPs...
SARS-CoV-2 can damage not only the lungs but also liver and kidney. Most critically ill patients with coronavirus disease 2019 (COVID-19) have kidney dysfunction. We aim to investigate levels of function indexes in mild severe COVID-19 their capability predict severity disease.The characteristics laboratory were compared between different conditions. applied binary logistic regression find independent risk factors patients. Receiver operating characteristic (ROC) analysis was used using...
Formononetin has proven to be anti‑inflammatory and able alleviate symptoms of certain allergic diseases. The present study aimed determine elucidate the potential effects formononetin in rhinitis. JME/CF15 cells were pretreated with at different doses, followed by stimulation IL‑13. Cell Counting Kit‑8 assay was performed cytotoxicity formononetin. expression levels inflammation‑related proteins, histamine, IgE, TNF‑α, IL‑1β, IL‑6, granulocyte‑macrophage colony‑stimulating factor eotaxin...
Abstract Background Forage quality is a fundamental determinant for livestock productivity in natural grasslands, and sensitive to the variations climate, soil, plant community composition. However, contributions of those factors regional variation forage largely remain unclear. We examined 45 alpine meadow communities over 23.6 × 10 4 km 2 area on eastern Qinghai-Tibet Plateau China. also drivers multiple indicators across scale. Results The results showed that grasslands this region had...
Individuals with inactive pulmonary tuberculosis (PTB) lesions were found to be high-risk populations for active PTB development. This retrospective study evaluated the association between different types of and development aiming provide epidemiological evidence developing precise intervention strategies. Based on a population-based case-finding project conducted elderly, total 154 028 subjects who had participated in 2020 baseline survey was included current analysis. During 2-year...
Abstract The prediction of virus–drug associations (VDAs) is crucial for drug repositioning, contributing to the identification latent antiviral drugs. In this study, we developed a graph-based integrated Gaussian kernel similarity (GiGs) method predicting potential VDAs in repositioning. GiGs model comprises three components: (i) collection experimentally validated VDA information and calculation virus sequence, chemical structure, side effect similarity; (ii) integration viruses drugs...
To assess the association of pulmonary tuberculosis (PTB) recurrence with fine particulate matter (PM2.5) and residential greenness using a population-based retrospective study design. All incident PTB patients, registered in Tuberculosis Information Management System (TBIMS) from 2015 to 2019 Quzhou City, China, were included. The data on PM2.5 exposure was extracted China High Air Pollutants dataset level estimated Normalized Difference Vegetation Index (NDVI) values around patient's...
Background To investigate the impact of major air pollutants on development tuberculosis (TB) among adults with latent infection (LTBI) in rural areas China. Methods Based a population-based multicenter cohort study conducted since 2013, we aimed to examine associations between various and risk active TB from LTBI. The estimates were assessed using time-dependent Cox regression models, non-linearity evaluated by restricted cubic splines. China High Air Pollutants datasets used feature...
Background and objectives Diaphragmatic paralysis following supraclavicular brachial plexus block (SCBPB) is ascribed to phrenic nerve palsy. This study investigated the effect of 2 volumes 0.375% ropivacaine on efficacy as a surgical anesthetic an analgesic examined diaphragm compound muscle action potentials (CMAPs) pulmonary function before after SCBPB. Methods Eighty patients scheduled for removal hardware internal fixation healing upper limb fracture distal shoulder were randomized...
The aggravation of soil salinization limits the growth and development plants. AP2/ERF transcription factors (TFs) have been identified play essential roles in plant stress response processes. In this study, function PagERF16 was detected using overexpressing (OX) RNAi transgenic poplar 84K hybrids. Plant growth, stomatal conductance, antioxidant enzymes activity, co-expressed TFs were analyzed morphological, physiological, molecular methods. OX showed a more robust lateral root system with...
Our knowledge of grassland biomass and its relationships with abiotic biotic factors on eastern margin the Tibetan Plateau is extremely limited. Here, we measured above-ground (AGB), below-ground (BGB) root/shoot ratio (R/S) alpine meadow, explored their driving factors, including (altitude slope properties, climate) (plant community properties) based field survey from 53 sites Plateau. The results showed that median values AGB, BGB R/S meadow in this region were 284.44 g m-2, 2232.98 m-2...
Reversing the hepatic inflammatory and immunosuppressive microenvironment caused by gut microbiota-derived lipopolysaccharides (LPS), accumulating to liver through gut-liver axis, is crucial for suppressing hepatocellular carcinoma (HCC) metastasis. However, synergistically manipulating LPS-induced inflammation microbiota remains a daunting task. Herein, Trojan-horse strategy proposed using an oral dextran-carbenoxolone (DEX-CBX) conjugate, which combines prebiotic glycyrrhetinic acid (GA)...
Background and Objectives: The knee is innervated by the femoral, obturator, sciatic nerves. An infrainguinal fascia iliaca compartment block (FICB) often used as a technique for pain management after hip arthroplasty. This approach blocks femoral nerve, lateral cutaneous obturator nerve. Previous studies show suprainguinal FICB achieves improved postoperative analgesia compared with fracture. However, analgesic effects of or on nerve total arthroplasty (TKA) remain to be established. study...
Toxoplasmosis is a world-wide zoonosis that causes significant public health and veterinary problems. The study of vaccines remains the most promising method for future prevention control toxoplasmosis. Recombinant Toxoplasma gondii cyclophilin has been shown to have potent PPIase IL-12-inducing activities, thus promoting stabilization T. gondii's life cycle maintaining survival its host during evolution. In this study, gene was used construct DNA vaccine (pVAX1-TgCyP). immune response...
The coronavirus disease 2019 (COVID-19) is an epidemic caused by the Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) and spreading throughout world rapidly. Here we evaluated efficacy of Lopinavir/Ritonavir (LPV/r) its combination with other drugs in treatment COVID-19. We included 170 confirmed COVID-19 patients who had been cured discharged. Their antiviral therapies were LPV/r alone or combinations interferon (IFN), Novaferon Arbidol. medication comparing time negative...
ABSTRACT The recent outbreak of the coronavirus disease-2019 (COVID-19) caused serious challenges to human society in China and across world. COVID-19 induced pneumonia hosts carried a highly inter-person contagiousness. patients may carry severe symptoms, some them even die major organ failures. This study utilized machine learning algorithms build severeness detection model. Support vector (SVM) demonstrated promising accuracy after 32 features were detected be significantly associated...
Tuberculosis is a chronic inflammatory disease caused by Mycobacterium tuberculosis. When tuberculosis invades the human body, innate immunity first line of defense. However, how immune microenvironment responds remains unclear. In this research, we studied function each type cell and explained principle an microenvironment. Based on differences in microenvironment, modularized analysis response five cells two structural cells. The results showed that stress response, genes CXCL3, PTGS2...
Liver injury from drug-drug interactions (DDIs), notably with anti-tuberculosis drugs such as isoniazid, poses a significant safety concern. Electronic medical records contain comprehensive clinical information and have gained increasing attention potential resource for DDI detection. However, substantial portion of adverse drug reaction (ADR) is hidden in unstructured narrative text, which has yet to be efficiently harnessed, thereby introducing bias into the research. There need an...
Tumor development and progression are closely associated with various microRNAs (miRNAs/miRs). We have previously shown that Newcastle disease virus (NDV) strain 7793 induces oncolysis in lung cancer. However, how NDV exerts its oncolytic effect on cancer remains to be investigated. The present study assessed the role of miR‑204 NDV‑induced A549 cells by induction <em>in vitro</em>. was significantly upregulated NDV‑treated cells. Overexpression or inhibition Caspase‑3 Bax, major regulators...