A5073983604- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Extraction and Separation Processes
- Metal Extraction and Bioleaching
- Fatigue and fracture mechanics
- Minerals Flotation and Separation Techniques
- Pluripotent Stem Cells Research
- Economic Theory and Policy
- Metal Alloys Wear and Properties
- Circular RNAs in diseases
- Genetics and Neurodevelopmental Disorders
- Electrodeposition and Electroless Coatings
- ATP Synthase and ATPases Research
- Cancer-related Molecular Pathways
- Metallurgy and Material Forming
- Genetic factors in colorectal cancer
- Cardiac Ischemia and Reperfusion
- RNA and protein synthesis mechanisms
- Mesenchymal stem cell research
- Field-Flow Fractionation Techniques
- Hepatitis C virus research
- Fire effects on concrete materials
- Material Properties and Failure Mechanisms
- Mitochondrial Function and Pathology
Buenos Aires Interdisciplinary Political Economy Institute
2024
Centro Nacional de Biotecnología
2016-2024
Universidad Autónoma de Madrid
2016-2024
Universidad de Navarra
2024
University of Buenos Aires
2024
Navarre Institute of Health Research
2024
Spanish National Centre for Cardiovascular Research
2015-2022
University of the Basque Country
2010-2012
Abstract Introduction The mammalian adult heart maintains a continuous, low cardiomyocyte turnover rate throughout life. Although many cardiac stem cell populations have been studied, the natural source for homeostatic repair has not yet defined. Polycomb protein BMI1 is most representative marker of mouse systems. We evaluated relevance and role Bmi1 + cells in physiological homeostasis. Methods CreER/+ ; Rosa26 YFP/+ ( -YFP) mice were used lineage tracing strategy. After tamoxifen (TM)...
Abstract Background The inability of the adult mammalian heart to replace cells lost after severe cardiac injury compromises organ function. Although is one least regenerative organs in body, evidence accumulated recent decades indicates a certain degree renewal injury. We have evaluated role Bmi1 + progenitor ( -CPC) following acute myocardial infarction (AMI). Methods Cre/+ ; Rosa26 YFP/+ -YFP) mice were used for lineage tracing strategy. After tamoxifen (TM) induction, yellow fluorescent...
The dermal Panniculus carnosus (PC) muscle is important for wound contraction in lower mammals and represents an interesting model of regeneration due to its high cell turnover. resident satellite cells (the bona fide stem cells) remain poorly characterized. Here we analyzed PC with regard developmental origin purported function. Lineage tracing shows that they originate Myf5+, Pax3/Pax7+ populations. Skin wounding increased myofiber turnover, the progeny being involved but no detectable...
Oxidative stress-induced myocardial apoptosis and necrosis are critically involved in ischemic infarction, several sources of extracellular vesicles appear to be enriched therapeutic activities. The central objective was identify validate the differential exosome miRNA repertoire human cardiac progenitor cells (CPC). CPC exosomes were first analyzed by LC-MS/MS compared RNAseq with exomes mesenchymal stromal fibroblasts define their (exo-miRSEL). Proteomics demonstrated a highly significant...
Objective— Cardiac progenitor cells reside in the heart adulthood, although their physiological relevance remains unknown. Here, we demonstrate that after myocardial infarction, adult Bmi1 + (B lymphoma Mo-MLV insertion region 1 homolog [PCGF4]) cardiac are a key progenitor-like population neovascularization during ventricular remodeling. Approach and Results— These cells, which have strong vivo differentiation bias, mixture of endothelial- mesenchymal-related with vitro spontaneous...
Adult progenitor cells reside in specialized microenvironments which maintain their undifferentiated cell state and trigger regenerative responses following injury. Although these environments are well described several tissues, the cellular components that comprise cardiac environment where located remain unknown. Here we use Bmi1CreERT Bmi1GFP mice as genetic tools to trace damage-responsive throughout mouse lifespan. In adolescent mice, Bmi1+ broadly distributed myocardium. adult however,...
Decomposition of the resistance to fatigue crack growth into intrinsic and extrinsic component is very important for understanding failure mechanisms, relation microstructure modelling residual life. Crack closure four grades steel were estimated by difference between Kmax values effective ΔKeff (measured at load ratio R = 0.8) corresponding same rate. The results showed that obtained – not in agreement with available models, both Newman's model plasticity-induced from finite element...
En este artículo revisitamos la evidencia empírica de hipótesis convergencia absoluta en el crecimiento entre países 1950-2019, poniendo foco producto por trabajador. También ponemos a prueba Rodrik (2013) trabajador industria manufacturera utilizando una base nueva construida los autores, que primera vez lo mide dólares igual poder compra, para así investigar su relación con economía conjunto 1970-2018. Encontramos robusta partir del año 2000 y rechazamos sistemáticamente sin conjunto.
Hepatitis delta virus (HDV) infection represents the most severe form of human viral hepatitis; however, mechanisms underlying its pathology remain incompletely understood. We recently developed an HDV mouse model by injecting adeno-associated vectors (AAV) containing replication-competent HBV and genomes. This replicates many features infection, including liver injury. Notably, extent damage can be diminished with anti-TNF-α treatment. Here, we found that TNF-α is mainly produced...
The adult mammalian heart has been demonstrated to be endowed with low but real turnover capacity, especially for cardiomyocytes, the key functional cell type. source, however, of that capacity remains controversial. In this regard, we have defined and characterized a resident multipotent cardiac mouse progenitor population, Bmi1+DR (for Bmi1+ Damage-Responsive cells). is one types lowest ROS (Reactive Oxygen Species) levels in heart, being particularly by their close relationship vessels,...
Resistance to fatigue crack propagation is divided into the intrinsic (effective) component and extrinsic component, represented by closure, which very significant in near-threshold regime. Crack growth rate measurements were done on compact tension specimens made of ferritic-pearlitic steel for automotive at stress ratio R = 0.1 0.8. closure was quantified from experimentally measured data using effective curve da/dN-ΔKeff a new expression Rcl Kcl/Kmax depending plasticity-induced...