A5101598241- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
- Renal Diseases and Glomerulopathies
- RNA Research and Splicing
- Bladder and Urothelial Cancer Treatments
- Molecular Biology Techniques and Applications
- Urinary and Genital Oncology Studies
- Genomics and Chromatin Dynamics
- Sperm and Testicular Function
- Urologic and reproductive health conditions
- Inflammasome and immune disorders
- Soft tissue tumor case studies
- Renal and related cancers
- Liver physiology and pathology
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Renal cell carcinoma treatment
- Sarcoma Diagnosis and Treatment
- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Genital Health and Disease
- Case Reports on Hematomas
Yamanashi Prefectural Central Hospital
2023-2024
Tokyo University of Agriculture and Technology
2022
Rohto Pharmaceutical (Japan)
1993-2022
National Defense Medical College
2015-2021
Japan Organization of Occupational Health and Safety
2016-2021
National Defense Medical College Hospital
2019-2021
Jichi Medical University
2020
Dokkyo Medical University Saitama Medical Center
2013-2015
Tohoku Medical and Pharmaceutical University
1989-2015
Nagoya City University
2012-2013
Antiviral and antibody therapies for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being recommended high-risk patients, but the potential development of multidrug-resistant mutations in immunocompromised patients is unclear.To investigate treatment course cases prolonged viral shedding an patient with SARS-CoV-2 infection, we conducted longitudinal measurements laboratory tests, chest computed tomography (CT) image evaluations, titers, antigen levels nasopharyngeal swabs....
BACKGROUND The aim of this study was to visualize early stage prostate cancer (Cap) in a clinical setting. In previous studies, the results magnetic resonance imaging (MRI) for screening Cap have rarely been confirmed by well-designed multisite biopsy. METHODS glands 90 men with elevated prostate-specific antigen (PSA) were imaged dynamic contrast-enhanced MRI (DCE-MRI) before transrectal ultrasound-guided 14-cores Each core divided into three subcore fractions (total 42 fractions) generate...
Purpose: We investigated the risk factors having an impact on achievement of stone-free status and success rate, as well likelihood recurrence, in patients undergoing shockwave lithotripsy. Patients Methods: evaluated characteristics outcomes 3023 (3254 renal units) with upper urinary-tract stones who underwent SWL at Funabashi Clinic over a 13-year period. assessed rates for 2844 (3061 3 months post-SWL. also determined recurrence rate 1078 (1139 had achieved that time. Results: Overall,...
This study provides new perspectives of the unique aspects platelet-derived growth factor β-receptor (PDGFR-β) signaling and biological responses through establishment a mutant mouse strain in which two <i>loxP</i> sequences were inserted into introns <i>PDGFR-β</i> genome sequences. Isolation skin fibroblasts from mice Cre recombinase transfection <i>in vitro</i> induced gene deletion (<i>PDGFR-β</i><sup>Δ/Δ</sup>). The resultant depletion PDGFR-β protein significantly attenuated...
Abstract Background Lung cancers are the most common type of human malignancy and intractable. generally classified into four histopathological subtypes: adenocarcinoma (AD), squamous cell carcinoma (SQ), large (LC), small (SC). Molecular biological characterization these subtypes has been performed mainly using DNA microarrays. In this study, we compared gene expression profiles twelve lung cancer lines more reliable quantitative real-time PCR (qPCR). Results We selected 100 genes from...
Ataxia telangiectasia (A-T) is a neurodegenerative disease caused by mutations in the large serine-threonine kinase ATM. A-T patients suffer from degeneration of cerebellum and show abnormal elevation serum alpha-fetoprotein. Here, we report novel signaling pathway that links ATM via cAMP-responsive-element-binding protein (CREB) to transcription factor ZFHX3 (also known as ATBF1), which turn promotes survival neurons inducing expression platelet-derived growth receptor β (PDGFRB). Notably,...
BACKGROUND Photoacoustic imaging, a noninvasive imaging based on optical excitation and ultrasonic detection, enables one to visualize the distribution of hemoglobin acquire map microvessels without using contrast agents. We examined whether it helps periprostatic improves visualization neurovascular bundle. METHODS developed photoacoustic (PAI) system with hand‐held probe combining illumination conventional linear array ultrasound probe. In experiments phantom model, was able vessels...
Objective Previous studies have suggested an association between gout susceptibility and common dysfunctional variants in ATP-binding cassette transporter subfamily G member 2/breast cancer resistance protein ( ABCG2/BCRP ), including rs72552713 (Q126X) rs2231142 (Q141K). However, the of rare ABCG2 with is unknown. Therefore, we investigated effects on this study. Methods We sequenced exons 480 patients healthy controls (Japanese males). also performed functional analyses non-synonymous...
Abstract To clarify the physiological and pathophysiological roles of intestinal urate excretion via ABCG2 in humans, we genotyped dysfunctional common variants, Q126X (rs72552713) Q141K (rs2231142), end-stage renal disease (hemodialysis) acute gastroenteritis patients, respectively. dysfunction markedly increased serum uric acid (SUA) levels 106 hemodialysis patients ( P = 1.1 × 10 −4 ), which demonstrated role for because their almost depends on ABCG2. Also, significantly elevated SUA 67...
The present study aimed to elucidate the function of AT motif-binding factor 1 (ATBF1) during neurogenesis in developing brain and primary cultures neuroepithelial cells cell lines (Neuro 2A P19 cells). Here, we show that ATBF1 is expressed differentiating field association with neuronal differentiation markers beta-tubulin MAP2 day E14.5 embryo rat brain, suggesting it promotes differentiation. In support this, suppresses nestin expression, a neural stem marker, activates promoter Neurod1...
Abstract Platelet‐derived growth factors (PDGFs) and PDGF receptors (PDGFRs) are widely expressed in the mammalian CNS, though their functional significance remains unclear. The corresponding null‐knockout mutations lethal. Here, we developed novel mutant mice which gene encoding β subunit of PDGFR ( PDGFR‐β ) was genetically deleted CNS neurons to elucidate role PDGFR‐β, particularly post‐natal stage. Our reached adulthood without apparent anatomical defects. In brain, immunohistochemical...
The genetic and pathogenic characteristics of SARS-CoV-2 have evolved from the original isolated strains; however, changes in viral virulence not been fully defined. In this study, we analyzed association between severity pathogenesis pneumonia humans variants that prevalent to date.We examined tropism SARS-CoV-2. A total 514 patients admitted February 2020 August 2022 were included evaluated for by computed tomography (CT) as a surrogate tropism.The prevalence each variant was follows:...
Abstract Schwann cells are crucially important for peripheral nerve regeneration. These synthesize several factors that supposed to enhance axonal regeneration when injured. Platelet‐derived growth factor (PDGF) B‐chain and its β‐receptor expressed in both normal nerves culture. To elucidate the role of PDGF‐B regeneration, we investigated expression cut or crush‐injured rat sciatic up 28 days. Northern blotting identified substantial increase PDGF transcripts injured nerves....
Abstract Cytokine release syndrome (CRS) is a severe and life‐threatening toxicity typically reported in chimeric antigen receptor T cell therapy rarely immune checkpoint inhibitor (ICI) therapy. This study reports the case of 75‐year‐old Japanese woman who received nivolumab plus ipilimumab for postoperative recurrence non‐small lung cancer. She was admitted to our hospital with fever, hypotension, hepatic disorder, thrombocytopenia. We observed slight skin rashes on her neck admission,...