A5051492694- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- Empathy and Medical Education
- Biosensors and Analytical Detection
- Innovations in Medical Education
- Respiratory Support and Mechanisms
- COVID-19 and healthcare impacts
- Intensive Care Unit Cognitive Disorders
- Patient-Provider Communication in Healthcare
- Bacterial Identification and Susceptibility Testing
- Sepsis Diagnosis and Treatment
- Clinical Reasoning and Diagnostic Skills
- COVID-19 diagnosis using AI
- Respiratory viral infections research
- Influenza Virus Research Studies
- Streptococcal Infections and Treatments
- Vagus Nerve Stimulation Research
- Antibiotic Use and Resistance
- Advanced biosensing and bioanalysis techniques
- Viral Infections and Immunology Research
- Platelet Disorders and Treatments
- Nosocomial Infections in ICU
- Animal Virus Infections Studies
Sigmund Freud University Vienna
2016-2024
Kaiser-Franz-Josef-Spital
2020-2022
Universitätszahnklinik Wien
2017-2022
University of Oxford
2021
Prince Charles Hospital
2021
Medical University of Vienna
2015-2019
Background The human Torque Teno virus (TTV) causes persistent viremia in most immunocompetent individuals. Elevated TTV levels are observed after solid organ transplantation and related to the extent of immunosuppression especially during phase maintenance immunosuppression. However, which increase early post-transplantation is associated with patient's immunosuppressive state unclear. Objectives In this study, we assessed dynamics detail first three months lung under a defined regimen...
The objective of our study was to evaluate the sensitivity and specificity rapid antigen detection tests versus those reverse transcriptase PCR (RT-PCR) using oral, anterior nasal, nasopharyngeal swabs. underlying prospective, diagnostic case-control-type accuracy included 87 hospitalized nonhospitalized participants in a positive negative sample cohort between 16 March 14 May 2021 two hospitals Vienna. SARS-CoV-2 infection status confirmed by RT-PCR. Participants self-performed one oral...
RT-qPCR-based diagnostic tests play important roles in combating virus-caused pandemics such as Covid-19. However, their dependence on sophisticated equipment and the associated costs often limits widespread use. Loop-mediated isothermal amplification after reverse transcription (RT-LAMP) is an alternative nucleic acid detection method that overcomes these limitations. Here, we present a rapid, robust, sensitive RT-LAMP-based SARS-CoV-2 assay. Our 40-min procedure bypasses RNA isolation...
Disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from mild illness to disease and death. In this study, we determined kinetics of viral loads, antibody responses (IgM, IgG, neutralization) SARS-CoV-2-specific CD4 T cells quantifying these parameters in 435 serial blood samples collected a cohort 29 COVID-19 patients with either moderate or during whole period hospitalization until Remarkably, there was no significant difference plateau levels...
The COVID-19 pandemic has demonstrated the need for massively-parallel, cost-effective tests monitoring viral spread. Here we present SARSeq, saliva analysis by RNA sequencing, a method to detect SARS-CoV-2 and other respiratory viruses on tens of thousands samples in parallel. SARSeq relies next generation sequencing multiple amplicons generated multiplexed RT-PCR reaction. Two-dimensional, unique dual indexing, using four indices per sample, enables unambiguous scalable assignment reads...
Since the outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, several reports indicated neurological involvement in COVID-19 disease. Muscle has also been reported as evidenced by creatine kinase (CK) elevations and myalgia.Creatine kinase, markers inflammation, pre-existing diseases statin use were extracted from records Austrian hospitalised patients. Disease severity was classified case intensive care unit (ICU) admission or mortality. patients additionally...
Gender-specific differences in the attitudes towards doctor-patient communication among medical students and physicians were assessed.A total of 150 51 from different departments took part study. The association, attitude experiences regarding assessed with a series tools questionnaires.Female doctors tended to describe positive attributes, such as "helpful", "sentimental", "voluble", "sociable", "gentle", "yielding" "peaceful". Male physicians, on other hand, described "overbearing",...
According to the European Public Health Authority guidance for ending isolation in context of COVID-19, a convalescent healthcare worker (HCW) can end their at home and resume work upon clinical improvement two negative RT-PCR tests from respiratory specimens obtained 24-h intervals least 8 days after onset symptoms. However, HCWs may shed SARS-CoV-2 viral RNA prolonged periods.40 healthy off because ongoing positive results combined nasopharyngeal (NP) oropharyngeal (OP) swabs following...
Abstract Global efforts to combat the Covid-19 pandemic caused by SARS-CoV-2 still heavily rely on RT-qPCR-based diagnostic tests. However, their high cost, moderate throughput and reliance sophisticated equipment limit widespread implementation. Loop-mediated isothermal amplification after reverse transcription (RT-LAMP) is an alternative detection method that has potential overcome these limitations. We present a rapid, robust, sensitive versatile RT-LAMP based assay. Our forty-minute...
In this study, we comprehensively analyzed multispecific antibody kinetics of different immunoglobulins in hospitalized patients with acute severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Three hundred fifty-four blood samples longitudinally obtained from 81 IgG-seroconverting progressed disease 2019 (CoVID-19) were quantified for spike 1 (S1), S2, and nucleocapsid protein (NCP)-specific IgM, IgA, IgG, total Ig antibodies using a microarray, 11 enzyme-linked immunosorbent...
Objectives The diagnosis of invasive Candida infection remains challenging due to tests with slow turnaround times or mediocre performance. T2MR is a new diagnostic tool. We investigated the accuracy T2Candida® panel (T2) in comparison blood culture (BC) and SeptiFast® (SF) for detection five different species among high-risk ICU patients suspected candidemia. Methods analysed samples collected from candidemia (177 138 patients) August 2018 April 2020. Blood were concurrently by BC, SF...
Standardized patients (SP) have been successfully utilized in medical education to train students' communication skills. At the Medical University of Vienna training with SPs psychiatry is a mandatory part curriculum. In training, SP plays role four different suffering from depression/suicidal tendencies, somatoform disorder, anxiety or borderline disorder while student attempts gather patient's history. Both instructor and then give constructive feedback afterwards. The aim study was...
Anticoagulation was associated with improved survival of hospitalized coronavirus disease 2019 (COVID-19) patients in large-scale studies. Yet, the development COVID-19-associated coagulopathy (CAC) and mechanism responsible for anticoagulated COVID-19 remain largely elusive. This investigation aimed to explore effects anticoagulation low-molecular-weight heparin (LMWH) particular on patient outcome, CAC development, thromboinflammation, cell death, viral persistence.Data 586 from three...
Thromboembolic complications are frequently observed in Coronavirus disease 2019 (COVID-19). While COVID-19 is linked to platelet dysregulation, the association between outcome and function less clear. We prospectively monitored activation reactivity 97 patients during first week of hospitalization determined plasma markers degranulation inflammation. Adverse was associated with increased basal diminished responses, which aggravated over time. Especially GPIIb/IIIa responses were abrogated,...
Covid-19 is an infectious disease associated with cytokine storms and derailed sympatho-vagal balance leading to respiratory distress, hypoxemia cardiovascular damage. We applied the auricular vagus nerve stimulation modulate parasympathetic nervous system, activate anti-inflammatory pathways, reestablish abnormal balance. aVNS performed percutaneously using miniature needle electrodes in ear regions innervated by nerve. In terms of a randomized prospective study, chronic started critical,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a high mortality. To date no trial comparing hydroxychloroquine (HCQ) and lopinavir/ritonavir (LPV/RTV) has been performed.
Background: The fatal consequences of an infection with severe acute respiratory syndrome coronavirus 2 are not only caused by pneumonia, but also thrombosis. Platelets important regulators thrombosis, their involvement in the pathogenesis COVID-19 is largely unknown. aim this study was to determine functional and biochemical profile patients dependence mortality within 5-days after hospitalization. Methods: COVID-19-related platelet phenotype examined analyzing basal activation state via...
A high rate of bacterial and fungal superinfections was reported in critically ill patients with COVID-19. However, diagnosis can be challenging. The aim this study is to evaluate the sensitivity clinical utility point-of-care method T2 magnetic resonance (T2MR) gold standard: blood culture. T2MR potentially detect five different Candida species six common bacteria (so-called "ESKAPE" pathogens including Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinet`obacter baumanii,...
Coronavirus disease 2019 (COVID-19) induces a hypercoagulatory state that frequently leads to thromboembolic complications. Whereas anticoagulation is associated with reduced mortality, the role of antiplatelet therapy in COVID-19 less clear. We retrospectively analyzed effect and 578 hospitalized patients prospectively monitored 110 for circulating microthrombi plasma markers coagulation first week admission. Moreover, we determined platelet shape change also thrombi postmortem lung...
Background The COVID-19 pandemic was largely driven by genetic mutations of SARS-CoV-2, leading in some instances to enhanced infectiousness the virus or its capacity evade host immune system. To closely monitor SARS-CoV-2 evolution and resulting variants at genomic-level, an innovative pipeline termed SARSeq developed Austria. Aim We discuss technical aspects pipeline, describe performance present noteworthy results it enabled during Methods set up as a collaboration between private public...
Background: To date, no oral antiviral drug has proven to be beneficial in hospitalized patients with COVID-19. Methods: In this randomized, controlled, open-label, platform trial, we randomly assigned ≥18 years COVID-19 pneumonia receive either camostat mesylate (CM) (considered standard-of-care) or lopinavir/ritonavir (LPV/RTV). The primary endpoint was time sustained clinical improvement (≥48 h) of at least one point on the 7-category WHO scale. Secondary endpoints included length stay...