A5037508656- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Infection Control in Healthcare
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 detection and testing
- Bacterial Identification and Susceptibility Testing
- Plant Pathogens and Fungal Diseases
- Medical Device Sterilization and Disinfection
- Diatoms and Algae Research
- Transgenic Plants and Applications
- Healthcare and Environmental Waste Management
- Viral gastroenteritis research and epidemiology
- Yersinia bacterium, plague, ectoparasites research
- German Social Sciences and History
- Neutropenia and Cancer Infections
- Material Properties and Applications
- Urinary Tract Infections Management
- Sepsis Diagnosis and Treatment
- Ecology, Conservation, and Geographical Studies
- Ergonomics and Human Factors
- Advanced Theoretical and Applied Studies in Material Sciences and Geometry
- Streptococcal Infections and Treatments
- Nosocomial Infections in ICU
- Orthopaedic implants and arthroplasty
- Infection Control and Ventilation
Innsbruck Medical University
2017-2025
Universität Innsbruck
2017-2025
Vyatka State University
2022
: The BIOFIRE Joint Infection (JI) Panel is a diagnostic tool that uses multiplex-PCR testing to detect microorganisms in synovial fluid specimens from patients suspected of having septic arthritis (SA) on native joints or prosthetic joint infections (PJIs).
Abstract Interlaboratory evaluations of Mucorales qPCR assays were developed to assess the reproducibility and performance methods currently used. The participants comprised 12 laboratories from French university hospitals (nine them participating in Modimucor study) 11 Fungal PCR Initiative. For panel 1, three sera each spiked with DNA different species (Rhizomucor pusillus, Lichtheimia corymbifera, Rhizopus oryzae). 2, six concentrations R. pusillus L. corymbifera (1, 10, 100 genomes/ml)...
Objectives The diagnosis of invasive Candida infection remains challenging due to tests with slow turnaround times or mediocre performance. T2MR is a new diagnostic tool. We investigated the accuracy T2Candida® panel (T2) in comparison blood culture (BC) and SeptiFast® (SF) for detection five different species among high-risk ICU patients suspected candidemia. Methods analysed samples collected from candidemia (177 138 patients) August 2018 April 2020. Blood were concurrently by BC, SF...
Candidemia poses a major threat to ICU patients and is routinely diagnosed by blood culture, which known for its low sensitivity long turnaround times. We compared the performance of novel, Candida-specific multiplex real-time PCR assay (Fungiplex® Candida IVD Real-Time Kit) with culture another established diagnostic (LightCycler SeptiFast Test) respect detection from whole samples. Clinical samples 58 were analyzed standard (BC) simultaneously tested Fungiplex (FP) test (SF) molecular spp....
Abstract Wastewater-based epidemiology (WBE) is an effective approach for tracking information on spatial distribution and temporal trends of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the community level. Herein, development, implementation, operation wastewater monitoring program serving Tyrol – a federal province Austria are described. The development this was initiated by Tyrolean health authorities end first phase Coronavirus disease 2019 (COVID-19) pandemic (May...
Bronchoalveolar lavage fluid (BALF) is the key sample type for diagnosing Pneumocystis jirovecii pneumonia, with quantitative PCR (qPCR) providing high sensitivity and specificity. However, processing varies considerably between laboratories, optimal nucleic acid extraction method BALF remains undetermined. This retrospective multicenter study, conducted in 12 centers as part of Fungal Initiative, assessed efficacy P. detection by qPCR different fractions, including whole (WHO), pellet...
Abstract Background Vancomycin resistant enterococci (VRE) are an emerging problem in health care settings. The purpose of the investigation was to assess extent outbreak including environmental contamination and limit further transmission. Methods We used retrospective patient laboratory data pulse field gel electrophoresis (PFGE) typing virulence resistance gene analysis. For comparison medians Mann-Whitney for proportions Fisher exact tests were used. Results PFGE VRE strains 15 cases a...
Hemolytic uremic syndrome (eHUS) is a severe complication of human infections with Shiga toxins (Stxs)-producing Escherichia coli. A key step in the pathogenesis eHUS interaction Stxs blood components before targeting renal endothelial cells. Here, we show that single proteolytic cleavage Stx2a A-subunit, resulting into two fragments (A1 and A2) linked by disulfide bridge (cleaved Stx2a), dictates different binding abilities. Uncleaved was confirmed to bind neutrophils trigger...
Blood stream infections pose a major challenge for clinicians as the immediate application of an appropriate antibiotic treatment is vital factor to safe patients' lives. This preliminary study compares three different systems promising fast pathogen identification and susceptibility testing in comparison conventional blood culture (BC): (i) rapid antimicrobial protocol according EUCAST combination with Sepsityper® kit (sRAST), (ii) direct inoculation method on VITEK® 2 system (dVIT) (iii)...
ABSTRACT The aim of this study was to identify parameters influencing DNA extraction and PCR amplification efficiencies in an attempt standardize Mucorales qPCR. Fungal Initiative Laboratory Working Group distributed two panels simulated samples 26 laboratories: Panel A (six sera spiked with one negative control serum) B extracts). underwent each laboratory according the local procedure were sent a central for testing using three different qPCR techniques: in-house assay commercial assays...
Abstract We have proposed optimal methods of treating both the waste- and stormwater for metallic soluble mercury within soil mercury-based chlorine- sodium-hydroxide production sites. The problem has been solved by combining physical, chemical physicochemical treatment methods. Through use various filtering materials, coagulants flocculants followed sorption through AB-17-8 Lewatit TR-214 ion exchangers, level wastewater decreased about 99.9%. Demercurization mercury-contaminated areas to...