A5101568642- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Physical Activity and Health
- Delphi Technique in Research
- Retinal Diseases and Treatments
- Glioma Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- HIV, Drug Use, Sexual Risk
- Nursing Diagnosis and Documentation
- HIV/AIDS Research and Interventions
- Cardiovascular and exercise physiology
- Anesthesia and Neurotoxicity Research
- Respiratory and Cough-Related Research
- Chronic Disease Management Strategies
- Cancer survivorship and care
- Retinal Imaging and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- School Health and Nursing Education
- Homelessness and Social Issues
- Health and Wellbeing Research
- Intensive Care Unit Cognitive Disorders
- Glaucoma and retinal disorders
- Hepatitis C virus research
- Anesthesia and Sedative Agents
AstraZeneca (Sweden)
2015-2024
Lund University
1998-2022
Skåne University Hospital
2015-2022
AstraZeneca (Italy)
2021
Karolinska Institutet
2007-2020
Örebro University Hospital
2017-2020
Public Health Agency of Sweden
2016-2020
GlaxoSmithKline (United Kingdom)
2017
Quest University Canada
2017
COPD Foundation
2017
Isoflurane and related anesthetics are widely used to anesthetize children, ranging from premature babies adolescents. Concerns have been raised about the safety of these in pediatric patients, particularly regarding possible negative effects on cognition. The purpose this study was investigate repeated isoflurane exposure juvenile mature animals cognition neurogenesis. Postnatal day 14 (P14) rats mice, as well adult (P60) rats, were anesthetized with for 35 mins daily four successive days....
To determine diurnal variability of symptoms in chronic obstructive pulmonary disease (COPD) and to assess the impact COPD upon patients' morning activities routines.Quantitative internet interviews with 803 patients from Europe USA, including 289 severe COPD. Severe was defined according regular use medication, third level breathlessness or above using modified Medical Research Council (MRC) dyspnoea scale (MRC score > =3) one more exacerbations preceding 12 months.Morning worst time day...
No current patient-centred instrument captures all dimensions of physical activity in chronic obstructive pulmonary disease (COPD). Our objective was item reduction and initial validation two instruments to measure COPD. Physical assessed a 6-week, randomised, two-way cross-over, multicentre study using PROactive draft questionnaires (daily clinical visit versions) monitors. Item followed an iterative process including classical Rasch model analyses, input from patients experts. 236 COPD...
Physical activity (PA) is of key importance for health among healthy persons and individuals with chronic obstructive pulmonary disease (COPD). PA has multiple dimensions that can be assessed quantified objectively using monitors. Moreover, as shown in the published literature, variable methodologies have been used to date quantify COPD, precluding clear comparisons outcomes across studies. The present paper aims provide a summary available literature rationale behind measured proposes...
Abstract Background Fast-track (FT) programmes are multimodal, evidence-based approaches to optimize patient outcome after surgery. The aim of this study was evaluate the safety, clinical and patients' experience a FT programme pancreaticoduodenectomy (PD) in high-volume institution Sweden. Methods Consecutive patients undergoing PD were studied before implementation programme. changes included earlier mobilization, standardized removal nasogastric tube drain, start oral intake. Patient...
Depression symptoms reduce physical activity in COPD patients: a prospective multicenter study Iván Dueñas-Espín,1–5 Heleen Demeyer,6 Elena Gimeno-Santos,1–3 Michael I Polkey,7 Nicholas S Hopkinson,7 Roberto A Rabinovich,8 Fabienne Dobbels,9 Niklas Karlsson,10 Thierry Troosters,6,11 Judith Garcia-Aymerich1–3 On behalf of the PROactive Consortium 1ISGlobal, Centre for Research Environmental Epidemiology (CREAL), 2Universitat Pompeu Fabra (UPF), 3CIBEREpidemiología y Salud Pública (CIBERESP),...
Studies of asthma and chronic obstructive pulmonary disease (COPD) typically focus on these diagnoses separately, limiting understanding mechanisms treatment options. NOVELTY is a global, 3-year, prospective observational study patients with and/or COPD from real-world clinical practice. We investigated heterogeneity overlap by diagnosis severity in this cohort.Patients physician-assigned asthma, or both (asthma+COPD) were enrolled, stratified severity. Baseline characteristics reported...
Although physical activity is considered an important therapeutic target in chronic obstructive pulmonary disease (COPD), what "physical activity" means to COPD patients and how their perspective best measured poorly understood. We designed a conceptual framework, guiding the development content validation of two patient reported outcome (PRO) instruments on (PROactive PRO instruments). 116 from four European countries with diverse demographics phenotypes participated three consecutive...
The Daily-PROactive and Clinical visit-PROactive Physical Activity (D-PPAC C-PPAC) instruments in chronic obstructive pulmonary disease (COPD) combines questionnaire with activity monitor data to measure patients' experience of physical activity. Their amount, difficulty total scores range from 0 (worst) 100 (best) but require further psychometric evaluation.To test reliability, validity responsiveness, define minimal important difference (MID), the D-PPAC C-PPAC instruments, a large...
This report concerns the development and validation of two patient-reported outcomes questionnaires developed to assess chronic obstructive pulmonary disease (COPD) patients’ ability perform morning activities evaluate their symptoms. Based on interviews with COPD patients, Capacity Daily Living during Morning (CDLM) questionnaire Global Chest Symptoms Questionnaire (GCSQ) were developed, linguistically validated incorporated into multicentre, randomised trials involving a total 1,100...
We investigated the effects of ionizing radiation on microvessel structure and complexity in hippocampus. also assessed neurogenesis neurovascular niche. Postnatal day 14 male C57BL/6 mice received a single dose 8 Gy to whole brain were killed 6 hours, 1 week, 7 weeks, or year later. Irradiation decreased total number microvessels branching points from week onwards area weeks after irradiation. After an initial increase vascular parameter densities, concomitant with reduced growth...
Asthma and chronic obstructive pulmonary disease (COPD) have overlapping clinical features share pathobiological mechanisms but are often considered distinct disorders. Prospective, observational studies across asthma, COPD asthma–COPD overlap limited. NOVELTY is a global, prospective 3-year study enrolling ∼12 000 patients ≥12 years of age from primary specialist practices in 19 countries (ClinicalTrials.gov identifier: NCT02760329 ). NOVELTY's objectives to describe patient...
Abstract Background Women who inject drugs (WWID) show higher levels of injecting risk behaviour compared to men, putting them at contracting HIV and hepatitis C (HCV). Compared WWID are also less present in harm reduction programs such as needle exchange (NEP). The aim this study is investigate reasons for, barriers to, participation NEP among Sweden, identify measures that could be taken strengthen the program increase WWID. Method In-depth interviews (IDIs) were conducted with 20 had...
Background and aims: Sharing of unsterile injection equipment contributes to transmission hepatitis C virus (HCV), HIV B (HBV) among people who inject drugs (PWID) but is largely preventable through needle exchange programmes (NEP). Sweden has been one the last countries in Europe scale up access NEP for PWID, consequently have high prevalence rates HCV HIV. The aim study was investigate demographic drug-related determinants risk behaviours, sharing needle/syringe paraphernalia, patterns...
Background The GOLD multidimensional classification of COPD severity combines the exacerbation risk with symptom experience, for which 3 different questionnaires are permitted. This study investigated differences in physical activity (PA) quadrants and patient's distribution relation to questionnaire used. Methods 136 patients (58±21% FEV1 predicted, 34F/102M) completed assessment test (CAT), clinical (CCQ) modified Medical Research Council (mMRC) questionnaire. Exacerbation history,...
The classification of rhinitis used in reviews and consensus guidelines includes a subgroup nonallergic called ''hormonal rhinitis'' (1-3). Hypothyroidism acromegaly are mentioned, but there very few modern studies published on the subject, even though is clinical impression that such conditions do exist. Exclusively female causes nasal symptoms this ''hormonal'' type menstrual cycle pregnancy. These two phenomena have been more studied recent years. Nasal mucosal swelling can be caused by...
Research has suggested a significant burden for patients with asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). However, few studies have studied this population in the People's Republic of China, region midst rapid epidemiological change respect to respiratory disease. The aim study was assess prevalence ACOS and its association patient outcomes urban China.Data from 2010, 2012, 2013 China National Health Wellness Survey, an Internet-based survey adults were used...
To estimate the prevalence of mild asthma in urban China and to measure association between severity quality life (QOL), work productivity, healthcare resource use.Data were from National Health Wellness Surveys (NHWS) conducted 2010 2013 (N = 59,935), Internet-based surveys adults China. Patients categorized by according self-report Global Initiative for Asthma (GINA2014) guidelines via self-reported medication use (mild [GINA 1-2] vs moderate/severe 3-4]). Propensity scores used identify...
Abstract Background No short patient-reported outcome (PRO) instruments assess overall health status across different obstructive lung diseases. Thus, the wording of introduction to Chronic Obstructive Pulmonary Disease (COPD) Assessment Test (CAT) was modified permit use in asthma and/or COPD. This tool is called Airways (CAAT). Methods The psychometric properties CAAT were evaluated using baseline data from NOVELTY study (NCT02760329) patients with physician-assigned asthma, + COPD or...
Introduction The clinical validity of real-world walking cadence in people with COPD is unsettled. Our objective was to assess the levels, variability and association clinically relevant characteristics outcomes cadence. Methods We assessed (steps per minute during bouts longer than 10 s) from 7 days’ accelerometer data 593 individuals five European countries, functional validated questionnaires standardised tests. Severe exacerbations a 12-month follow-up were recorded patient reports...