A5090049105- Psychopathy, Forensic Psychiatry, Sexual Offending
- Personality Disorders and Psychopathology
- Genomic variations and chromosomal abnormalities
- Suicide and Self-Harm Studies
- Engineering Education and Curriculum Development
- Genetic Neurodegenerative Diseases
- Genomics and Rare Diseases
- Engineering Education and Pedagogy
- Psychotherapy Techniques and Applications
- Mitochondrial Function and Pathology
- Mental Health and Psychiatry
- Child and Adolescent Psychosocial and Emotional Development
- Genomics and Chromatin Dynamics
- Design Education and Practice
- Genetics and Neurodevelopmental Disorders
- Schizophrenia research and treatment
- Crime Patterns and Interventions
- Neurological disorders and treatments
- Healthcare cost, quality, practices
- Intraocular Surgery and Lenses
- Single-cell and spatial transcriptomics
- Free Will and Agency
- Healthcare Decision-Making and Restraints
- Creativity in Education and Neuroscience
- Problem and Project Based Learning
King's College London
2006-2024
South London and Maudsley NHS Foundation Trust
2012-2024
National Health Service
2024
Moffitt Cancer Center
2023
University of California, Los Angeles
2003-2022
University of Waterloo
2011-2020
Bethlem Royal Hospital
2020
MACOM (United States)
2020
UK Dementia Research Institute
2019
University of Oxford
2019
Copy number variants (CNVs) play an important role in human disease and population diversity. Advancements technology have allowed for the analysis of CNVs thousands individuals with addition to controls. These studies identified rare associated neuropsychiatric diseases such as autism, schizophrenia, intellectual disability. In addition, copy polymorphisms (CNPs) are present at higher frequencies population, show high diversity number, sequence, structure, been multiple phenotypes,...
Abstract The mismatch repair gene MSH3 has been implicated as a genetic modifier of the CAG·CTG repeat expansion disorders Huntington’s disease and myotonic dystrophy type 1. A recent genome-wide association study found rs557874766, an imputed single nucleotide polymorphism located within polymorphic 9 bp tandem in MSH3/DHFR, variant most significantly associated with progression disease. Using Illumina sequencing 1 subjects, we show that rs557874766 is alignment artefact, minor allele for...
Mutations in the ATM gene are responsible for autosomal recessive disorder ataxia-telangiectasia (A-T). Many different mutations have been identified using various techniques, with detection efficiencies ranging from 57 to 85%. In this study, we employed short tandem repeat (STR) haplotypes enhance mutation identification 55 unrelated A-T families of Iberian origin (20 Spanish, 17 Brazilian, and 18 Hispanic-American); were able identify 95% expected mutations. Allelic sizes standardized...
Background Treatment and risk management of forensic patients relies heavily on diagnosing psychopathology, yet the reliability clinical diagnoses personality disorder has been found to be only fair low. Structured instruments for global assessment are infrequently used in assessments possibly due their limited validity utility. Aims/methods The Shedler-Westen Assessment Procedure-200 (SWAP-200) was developed an effort address these limitations. Although good relation clinicians' diagnosis...
Cis-regulatory variation is considered to be an important determinant of human phenotypic variability, including susceptibility complex disease. Recent studies have shown that the effects cis-regulatory polymorphism on gene expression can differ widely between tissues. In present study, we tested whether also regions adult brain. We used relative allelic measure cis-effects RNA five candidate genes for neuropsychiatric illness (ZNF804A, NOS1, RGS4, AKT1 and TCF4) across multiple discrete...
There are widespread, genetically determined differences in gene expression. However, methods that compare transcript levels between individuals subject to trans-acting effects and environmental differences. By looking at allele-specific expression the F1 progeny of inbred mice, we can directly test for allelic imbalance (AI), which must be due cis-acting variants parental strains. We tested over one hundred genes AI C57Bl/6J A/J alleles including a validation set 23 enriched second 92 whose...
Recent data from mainly homogeneous European and African populations implicate a 140-bp region 5' to the transcriptional start site of LCT (the lactase gene) as regulatory for persistence nonpersistence. Because there are no studies US nonhomogeneous populations, we performed genotype/phenotype analysis -13910 -22018 single nucleotide polymorphisms (SNPs) in New England children, mostly ancestry.Duodenal biopsies were processed disaccharidase activities, RNA quantification by reverse...
Offenders with severe personality pathology are at significantly increased risk of serious and violent offending. In England Wales, offenders who likely to meet criteria for a diagnosis disorder managed within network ‘Offender Personality Disorder Pathway’ services. We conducted retrospective cohort study over 6 years, using linked routine datasets, examine the effectiveness these services on male (n = 28,321). compared outcomes those received simple case formulation had not been referred...
<b>Background</b><br /> Development of children with cerebral palsy (CP) depends on the quality parental care. The aim research was to compare parenting attitudes in mothers CP typically developing children, and study relationship between personality traits, stress, coping strategies self-efficacy CP.<br <br <b>Participants procedure</b><br Twenty-seven (MCCP) (mean age 35.50 years, SD = 4.83) twenty-eight 35.60 4.27) (MTDC) participated this study....
Purpose The purpose of this paper is to explore the views NHS England (NHSE) and Her Majesty’s Prison Probation Service (HMPPS) commissioners about Offender Personality Disorder (OPD) pathway. Design/methodology/approach A thematic analysis four semi-structured interviews with NHSE HMPPS conducted. Findings Commissioners offered a cautious but confident assessment potential effectiveness OPD pathway, drawing particular attention its enhance confidence competency staff, offer better value for...
Machine learning and statistical model based classifiers have increasingly been used with more complex high dimensional biological data obtained from high-throughput technologies. Understanding the impact of various factors associated large microarray datasets on predictive performance is computationally intensive, under investigated, yet vital in determining optimal number biomarkers for classification purposes aimed towards improved detection, diagnosis, therapeutic monitoring diseases. We...
Progress in personalised psychiatry is dependent on researchers having access to systematic and accurately acquired symptom data across clinical diagnoses. We have developed a structured psychiatric assessment tool, OPCRIT+, that being introduced into the electronic medical records system of South London Maudsley NHS Foundation Trust which can help achieve this. In this report we examine utility collected with tool. Cross-sectional mental state from mixed-diagnostic cohort 876 inpatients was...
The offender personality disorder (OPD) Pathway is a network of services across prison, health and community settings in England Wales providing psychological support for high-risk people who have offended are thought to disorder. As part national evaluation the Pathway, semi-structured interviews were carried out with 36 users determine their views about experiences these services; whether how impacted on wellbeing. Framework analysis was used analyze data. Participants reported positive...