A5087965170- Reproductive tract infections research
- Cervical Cancer and HPV Research
- SARS-CoV-2 and COVID-19 Research
- Lung Cancer Treatments and Mutations
- Urinary Tract Infections Management
- Breast Cancer Treatment Studies
- SARS-CoV-2 detection and testing
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Healthcare Regulation
- Cancer Immunotherapy and Biomarkers
- Breast Lesions and Carcinomas
- Vaccine Coverage and Hesitancy
- AI in cancer detection
- Genital Health and Disease
- Lung Cancer Research Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Ultrasound in Clinical Applications
- Syphilis Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Male Reproductive Health Studies
- Medical research and treatments
Universidade do Porto
2016-2025
Centre for Health Technology and Services Research
2024
Universidade do Estado do Rio de Janeiro
2021-2024
University of Trás-os-Montes and Alto Douro
2022
Hospital de São João
2021
University of Turin
2021
Instituto Nacional do Câncer
2017-2020
Universitat Autònoma de Barcelona
2015
Hospital Del Mar
2015
Hospital del Mar Research Institute
2015
We show that the SARS-CoV-2 B.1.1.7 lineage is highly disseminated in Portugal, with odds of proportion increasing at an estimated 89% (95% confidence interval: 83–95%) per week until 3 2021. RT-PCR spike gene target late detection (SGTL) can constitute a useful surrogate to track spread, besides failure (SGTF) proxy. SGTL/SGTF samples were associated statistically significant higher viral loads, but not substantial shift age distribution compared non-SGTF/SGTL cases.
We developed a case-case study to compare mRNA vaccine effectiveness against Delta versus Alpha coronavirus variants. used data on 2,097 case-patients with PCR-positive severe acute respiratory syndrome 2 infections reported in Portugal during May-July 2021. estimated the odds of breakthrough infection Delta-infected Alpha-infected patients by using conditional logistic regression adjusted for age group and sex matched week diagnosis. compared reverse-transcription PCR cycle threshold values...
Abstract Background In a context of multiple Omicron lineages circulation, it is relevant to clarify the effect vaccination and previous infections on risk infection severe post-infection outcomes. Methods Using electronic health records SARS-CoV-2 laboratory surveillance data, we conducted case-case cohort study covering period BA.2/BA.5 lineage replacement in Portugal, compare vaccine effectiveness complete primary booster dose against infection, COVID-19 hospitalization, mortality....
Objective To validate the use of Seegene Allplex™ Vaginitis assay in diagnosis candidiasis, bacterial vaginosis (BV) and trichomoniasis. Design Cross‐sectional, prospective study conducted a single centre. Setting Outpatient clinic gynaecology department. Population Consecutive symptomatic asymptomatic women (18–60 years age). Methods Comparison test with reference standards for vaginitis (cultures yeasts, Nugent BV nucleic acid amplification trichomoniasis). Main outcome measures...
Abstract Introduction Early reports showed that Omicron (BA.1) SARS-CoV-2 could be less severe. However, the magnitude of risk reduction hospitalization and mortality infections compared with Delta (B.1.617.2) is not yet clear. This study compares severe disease among patients infected variant in Portugal. Methods We conducted a cohort individuals diagnosed infection between 1 st 29 th December 2021. Cases were positive PCR test notified to national surveillance system. variants classified...
Lung cancer has the highest incidence and cancer-related mortality worldwide. In Portugal, it ranks as fourth most common cancer, with nearly 6000 new cases being diagnosed every year. is main cause of death among males third in females. Despite globally accepted guidelines recommendations for what would be ideal path a lung patient, several challenges occur real clinical management across world. The emphasize importance adequate screening high-risk individuals, precise tumour biopsy, an...
Abstract Background Information on vaccine effectiveness in a context of novel variants concern (VOC) emergence is key importance to inform public health policies. This study aimed estimate measure comparative between Omicron (BA.1) and Delta (B.1.617.2 sub‐lineages) VOC according vaccination exposure (primary or booster). Methods We developed case–case using data RT‐PCR SARS‐CoV‐2‐positive cases notified Portugal during Weeks 49–51, 2021. To obtain effectiveness, we compared the odds versus...
Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute Health early stages COVID-19 epidemic, collaboration with more than 50 laboratories distributed nationwide.By applying recent phylodynamic models that allow integration individual-based travel history, we reconstructed and characterized spatio-temporal dynamics introductions dissemination Portugal.We detected at least 277 independent introductions, mostly from European countries (namely United...
Triple negative breast cancer (TNBC) is characterized rapid tumor growth, and increased metastatic potential compared to other subtypes. However, pathological complete response (pCR) neoadjuvant chemotherapy (NACT) can predict patients with a better prognosis. Clinical predictors of pCR such as size (TS) are controversial. This study aims evaluate the influence TS on achieving pCR, associated survival outcomes.Medical records from 310 TNBC treated NACT between 2010 2013 in National Cancer...
Abstract Background The SARS-CoV-2 Delta variant (B.1.617.2), initially identified in India, has become predominant several countries, including Portugal. Few studies have compared the effectiveness of mRNA vaccines against versus Alpha concern (VOC) and estimated variant-specific viral loads vaccine infection breakthroughs cases. In context dominance, this information is critical to inform decision-makers regarding planning restrictions vaccination roll-out. Methods We developed a case-case...
Abstract Introduction Information on vaccine effectiveness and viral loads in a context of novel variants concern (VOC) emergence is key importance to inform public health policies. This study aimed estimate measure comparative between Omicron (BA.1) Delta (B.1.617.2 sub-lineages) VOC according vaccination exposure (primary or booster) time since primary compare cycle threshold (Ct) values infections the status as an indirect load. Methods We developed case-case using data RT-PCR SARS-CoV-2...
Almost all cervical cancers are related to the human papillomavirus (HPV). Future strategies for cancer screening will be based on HPV detection. The Hybrid Capture 2 (HC2) test is currently most widely used method screen HPV.To performance of Cervista HR screening.We examined 875 samples by HC2 and Cervista. Of these, 64 were high-grade intraepithelial neoplasia (CIN 2+) cases sensitivity assay. remaining 811 non-CIN 2+ cases, which compare specificity. noninferiority score was used, with...
Background and Objectives: One of the most frequently mutated oncogenes in cancer belongs to Ras family proto-oncogenes, which encode distinct key signaling events. RAS gain-of-function mutations are present ~30% all human cancers, with KRAS being isoform showing alterations different types including lung cancer. This study aimed investigate incidence mutations, concomitant advanced non-small cell adenocarcinoma patients. Materials Methods: was a retrospective study, where genomic DNA...
Intrinsic subtype of triple-negative breast cancer (TNBC) is based on genomic evaluation. In this study, we report the survival and pathological complete response (pCR) rates TNBC patients subtyped by IHC treated with neoadjuvant chemotherapy (NACT). A retrospective cohort 187 who received NACT between 2008 2017 was used, subtyping performed biopsy specimens before chemotherapy. The revealed predominant basal-like tumors (IHC-BL, 61%), followed immune-suppressed (IHC-BLIS, 31%), mesenchymal...
The intrinsic subtype of triple-negative breast cancer (TNBC) is based on genomic evaluation. In this study, we report the survival and pathological complete response (pCR) rates TNBC patients subtyped by IHC treated with neoadjuvant chemotherapy (NACT). A retrospective cohort 187 who received NACT between 2008 2017 was used, subtyping performed biopsy specimens before chemotherapy. revealed predominantly basal-like tumors (IHC-BL, 61%), followed immune-suppressed (IHC-BLIS, 31%),...
Some infectious agents have the potential to cause specific modifications in cellular microenvironment that could be propitious carcinogenesis process. Currently, there are viruses and bacteria, such as human papillomavirus (HPV) Helicobacter pylori, well established risk factors for neoplasia. Chlamydia trachomatis (CT) infections one of most common bacterial sexually transmitted worldwide, recent European data confirmed a continuous rise across Europe. The infection is often asymptomatic...