A5068796077- Malaria Research and Control
- Complement system in diseases
- HIV Research and Treatment
- Mosquito-borne diseases and control
- Invertebrate Immune Response Mechanisms
- Phytochemistry and Biological Activities
- Electrolyte and hormonal disorders
- T-cell and B-cell Immunology
- Vector-borne infectious diseases
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Traditional Chinese Medicine Analysis
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- interferon and immune responses
- Renal function and acid-base balance
- Research on Leishmaniasis Studies
- Pharmacological Effects of Natural Compounds
- Hepatitis Viruses Studies and Epidemiology
- Chemokine receptors and signaling
Burnet Institute
2018-2025
Monash University
2019-2021
Most studies on human immunity to malaria have focused the roles of immunoglobulin G (IgG), whereas IgM remain undefined. Analyzing multiple cohorts assess dynamics malaria-specific during experimentally induced and naturally acquired malaria, we identified activity against blood-stage parasites. We found that merozoite-specific appears rapidly in Plasmodium falciparum infection is prominent children adults with lifetime exposure, together IgG. Unexpectedly, persisted for extended periods...
Abstract A highly protective vaccine will greatly facilitate achieving and sustaining malaria elimination. Understanding mechanisms of antibody-mediated immunity is crucial for developing vaccines with high efficacy. Here, we identify key roles in humoral Fcγ-receptor (FcγR) interactions opsonic phagocytosis sporozoites. We a major role neutrophils mediating phagocytic clearance sporozoites peripheral blood, whereas monocytes contribute minor role. Antibodies also promote natural killer cell...
T-follicular CD4 T (Tfh) cells play essential roles in antibody induction during infection and following vaccination. In humans, peripheral Tfh (pTfh) are commonly analysed based on expression of CXCR3 CCR6, with different subsets pTfh (pTfh1, pTfh2, pTfh17) associated a context-dependent manner. malaria, the specific development is not clear. Several studies human malaria vaccination have identified an important role pTfh2 cells, which associate while pTfh1 do not. However, vitro animal...
Chimeric virus-like particles (VLP) allow the display of foreign antigens on their surface and have proved valuable in development safe subunit vaccines or drug delivery. However, finding an inexpensive production system a VLP scaffold that allows stable incorporation diverse, large are major challenges this field.In study, versatile cost-effective platform for chimeric was established. The membrane integral small protein (dS) duck hepatitis B virus chosen as industrially applied yeast...
T-follicular helper (Tfh) cells are key drivers of antibodies that protect from malaria. However, little is known regarding the host and parasite factors influence Tfh functional antibody development. Here, we use samples a large cross-sectional study children residing in an area high malaria transmission Uganda to characterize multiple parasites stages. We identify dramatic re-distribution cell compartment with age independent exposure, Th2-Tfh predominating early childhood, while Th1-Tfh...
Sequestration of Plasmodium falciparum–infected erythrocytes (IEs) in the microvasculature contributes to pathogenesis severe malaria children. This mechanism is mediated by antigens expressed on IE surface. However, knowledge specific targets and functions antibodies surface that protect against limited. Antibodies were examined a case-control study young children Papua New Guinea presenting with or uncomplicated (n = 448), using isolates virulent phenotype associated malaria, functional...
ABSTRACT The development of transmission-blocking vaccines against Plasmodium falciparum malaria could facilitate elimination. However, limitations in the knowledge human immune responses P. transmission stages, known as gametocytes, represent a critical roadblock to vaccine development. We evaluated antibodies acquired through natural exposure whole gametocytes and recombinant antigens expressed by including major candidates Pfs230 Pfs48/45 other Pf38, Pf12 Pf41. Among individuals residing...
ABSTRACT The development of effective malaria vaccines remains a global health priority. Currently, the most advanced vaccine, known as RTS,S, has only shown modest efficacy in clinical trials. Thus, more efficacious by improving formulation RTS,S for increased or to interrupt transmission are urgently needed. vaccine is based on presentation fragment sporozoite antigen surface virus-like particles (VLPs) human hepatitis B virus (HBV). In this study, we have developed and evaluated novel VLP...
Abstract T-follicular helper (Tfh) cells are key drivers of antibodies that protect from malaria. However, little is known regarding the host and parasite factors influence Tfh functional antibody development. Here, we use samples a large cross-sectional study children residing in an area high malaria transmission Uganda to characterize multiple parasites stages. We identify dramatic re-distribution cell compartment with age independent exposure, Th2-Tfh predominating early childhood, while...