A5100452819- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver physiology and pathology
- Cancer Mechanisms and Therapy
- Inflammatory Biomarkers in Disease Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Hedgehog Signaling Pathway Studies
- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- Chromatin Remodeling and Cancer
- Microbial Metabolic Engineering and Bioproduction
- Liver Disease and Transplantation
- Wnt/β-catenin signaling in development and cancer
- Synthesis and Biological Evaluation
- Traditional Chinese Medicine Analysis
- Infectious Diseases and Tuberculosis
- Protein Kinase Regulation and GTPase Signaling
- Neuropeptides and Animal Physiology
- Genomics, phytochemicals, and oxidative stress
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- interferon and immune responses
- EEG and Brain-Computer Interfaces
Sichuan University
2011-2025
West China Hospital of Sichuan University
2011-2025
Bridge University
2024
Huashan Hospital
2023
Fudan University
2023
Mengchao Hepatobiliary Hospital
2023
Fujian Medical University
2023
Ningbo Medical Center Lihuili Hospital
2023
Soochow University
2023
Harbin Medical University
2023
Chemokine (C-X3-C motif) Receptor 1 (CX3CR1) primarily mediates the chemotaxis and adhesion of immune cells. However, its role in hepatitis C virus (HCV)-induced early-stage liver cirrhosis remains unexplored. GSE15654 was downloaded from GEO database. The Cox regression model, CIBERSORT, LASSO technique were utilized to identify CX3CR1-associated infiltration genes (IIGs). Surgical resection samples collected for verification, including 3 healthy controls (HC), 4 individuals with...
Epidermal stratification of the mammalian skin requires proliferative basal progenitors to generate intermediate cells that separate from layer and are replaced by post-mitotic cells. Although Wnt signaling has been implicated in this developmental process, mechanism underlying Wnt-mediated regulation remains elusive. Here we show secreted is not required for their differentiation. However, epidermal production Wnts essential formation spinous through modulation a BMP-FGF cascade dermis. The...
Abstract Systemic therapy is typically the primary treatment choice for hepatocellular carcinoma (HCC) patients with extrahepatic metastases. Some may achieve partial response (PR) or complete (CR) systemic treatment, leading to possibility of their tumor becoming resectable. This study aimed investigate whether these could longer survival through surgical resection tumor. We retrospectively collected data from 150 HCC metastases treated at 15 different centers January 1st, 2015, November...
Objective The aim of this study was to investigate appropriate treatment strategies for recurrent intrahepatic hepatocellular carcinoma (HCC) in patients who fulfilled the Milan criteria at primary hepatectomy. Patients and methods A total 124 underwent curative-intent resection HCC our center between January 2007 March 2014 were retrospectively enrolled; had initially criteria, but developed recurrence. Seventy-four transarterial chemoembolization (TACE) another 50 repeat (RR) or...
Background: Nucleot(s)ide analog treatment (entecavir (ETV) and tenofovir (TDF)) is reported to be associated with decreased tumor recurrence death in HBV-related hepatocellular carcinoma (HCC) patients, yet further work needed evaluate the different efficacies of these two agents on prognosis early-stage HCC patients after curative liver resection. Material methods: From July 2017 January 2019, 148 who underwent resection were randomized receive TDF (n=74) or ETV therapy. The primary end...
Intrahepatic cholangiocarcinoma (iCCA) is closely correlated with hepatic progenitor cell (HPC) expansion and liver fibrosis. Brahma-related gene 1 (Brg1), an enzymatic subunit of the switch/sucrose nonfermentable complex that critical in stem maintenance tumor promotion, prominently up-regulated both HPCs iCCA; however, its role this correlation remains undefined.A retrospective cohort study indicated high Brg1 expression suggests poor prognosis patients iCCA. In chronically injured livers...
The combination of locoregional and systemic therapy may achieve remarkable tumor response for unresectable hepatocellular carcinoma (HCC). We aimed to investigate the correlation between radiologic pathologic responses following therapy, evaluate their prognostic values, establish a non-invasive prediction system response. This single-center retrospective study included 112 consecutive patients with HCC who underwent followed by liver resection or transplantation. Radiologic was assessed...
The risk of hepatocellular carcinoma (HCC) recurrence following surgical resection remains high, approaching 50%-70% at 5 years, with the highest occurring in first year after resection. This study aimed to evaluate efficacy and safety lenvatinib as adjuvant therapy for HCC. In this open-label, single-arm, prospective, multicenter Phase II clinical study, a total 51 hCC patients China Liver Cancer (CNLC) stage IIb/IIIa (ie tumor number ≥ 4 or vascular invasion, equivalent BCLC B/C) who...
Mandibular patterning information initially resides in the epithelium during development. However, how transcriptional regulation of epithelium-derived signaling controls morphogenesis mandible remains elusive. Using ShhCre to target mandibular epithelium, we ablated transcription factor Islet1, resulting a distally truncated via unbalanced cell apoptosis and decreased proliferation distal mesenchyme. Loss Islet1 caused lack cartilage at tip, leading fusion two growing elements surrounding...
Aim: As high gamma-glutamyltransferase level or low albumin had negative impact on the prognosis of hepatocellular carcinoma (HCC), prognostic role to ratio (AGR) in patients underwent hepatectomy remains unclear. Methods: Between January 2007 and December 2015, 1143 HCC after were reviewed from a prospectively maintained database West China Hospital. All qualified patients(n=959) classified as training set (year 2007-2012, n=480) validation 2012-2017, n=479). Time‐dependent receiver...
Abstract Background Antiviral therapy should reduce the recurrence of hepatitis B virus‐related hepatocellular carcinoma (HBV‐related HCC) after surgical resection. However, there is little research on whether various antiviral drugs have different prognostic effects in patients with HBV‐related HCC curative liver The present study compared nucleotide analog (NtA) and nucleoside (NsA) therapies resection prognosis HCC. Methods A total 1303 who received hepatectomy at five institutes between...
Asymmetric expression of sonic hedgehog (Shh) in the left side Hensen's node, a crucial step for specifying left-right (LR) axis chick embryo, is established by repression Shhexpression right node. The transcriptional regulator that mediates this has not been identified. We report isolation and characterization novel Polycomblike 2 gene, Pcl2, which encodes transcription repressor displays an asymmetric expression, downstream from Activin-βB Bmp4, node developing embryo. In vitro mapping...
Rationale: Congenital biliary atresia (BA) is a destructive obliterative cholangiopathy of neonates that affects both intrahepatic and extrahepatic bile ducts. However, the cause BA largely unknown. Methods: We explored cell junctions polarity complexes in early biopsy livers by immunofluorescence staining western blot. Cdc42, as key junction regulator, was found dramatically decreased livers. Therefore, order to investigate role Cdc42 development, we constructed liver-specific tamoxifen...
Treatments about small hepatocellular carcinoma (HCC) and hypersplenism associated with good hepatic reserve are not well established. The aim of this study was to investigate the outcome synchronous hepatectomy splenectomy for those patients.Splenomegaly were defined as a pathological spleen. Seven hundred fifty-six patients HCC (381 spleen, 375 without spleen) divided into three groups. One ten 381 underwent (group A), 271 alone (Group B) spleen C).The influence different treatments...