A5044714558- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Endometrial and Cervical Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Medical Imaging Techniques and Applications
- Head and Neck Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- Semiconductor materials and devices
- Cervical Cancer and HPV Research
- Brain Metastases and Treatment
- Management of metastatic bone disease
- Breast Lesions and Carcinomas
- Radiation Dose and Imaging
- Ovarian cancer diagnosis and treatment
- Advances in Oncology and Radiotherapy
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Spacecraft Design and Technology
- Bladder and Urothelial Cancer Treatments
- Cancer Diagnosis and Treatment
- Parallel Computing and Optimization Techniques
- Radiation Detection and Scintillator Technologies
- Lung Cancer Treatments and Mutations
Hokkaido University Hospital
2015-2024
Hokkaido University
2006-2023
Kyushu Institute of Technology
2020
Veterinary Medical Center
2020
The University of Tokyo
2020
Kobe University
2013
Hosei University
2013
Japanese Society of Medical Oncology
2012
Chuo University
2011
Kitasato University
2009
Abstract Background We performed a dosimetric comparison of spot-scanning proton therapy (SSPT) and intensity-modulated radiation (IMRT) for hepatocellular carcinoma (HCC) to investigate the impact tumor size on risk induced liver disease (RILD). Methods A number alternative plans were generated 10 patients with HCC. The gross volumes (GTV) varied from 20.1 2194.5 cm 3 . Assuming all GTVs spherical, nominal diameter was calculated ranged 3.4 16.1 cm. prescription dose 60 Gy IMRT or cobalt...
Purpose: In spot‐scanning proton therapy, the interplay effect between tumor motion and beam delivery leads to deterioration of dose distribution. To mitigate impact motion, gating in combination with repainting is one most promising methods that have been proposed. This study focused on a synchrotron‐based therapy system integrated real‐time monitoring. The authors investigated effectiveness terms both delivered distribution irradiation time by conducting simulations patients’ data....
Abstract Introduction Ductal carcinoma in situ (DCIS) is characterized by non-invasive cancerous cell growth within the breast ducts. Although radiotherapy commonly used treatment of DCIS, effect and molecular mechanism ionizing radiation (IR) on DCIS are not well understood, invasive recurrence following remains a significant clinical problem. This study investigated effects IR clinically relevant model Akt-driven identified possible mechanisms underlying progression surviving cells....
We prospectively assessed the utility of intensity-modulated radiation therapy (IMRT) with urethral dose reduction and a small margin between clinical target volume (CTV) planning (PTV) for patients localized prostate cancer. The study population was 110 in low- (14.5%), intermediate- (41.8%), high-risk (43.6%) categories. Three gold fiducial markers were inserted into prostate. A soft guide-wire used to identify urethra when computed tomography (CT) scan treatment performed. constraint V70...
Abstract Background In-room cone-beam computerized tomography (CBCT) imaging is a promising method to reduce setup errors, especially in organs such as the bladder that often have large intrafractional variations due organ movement. CBCT image quality limited by low contrast and artifacts, but few data been reported about inter-observer variability of boundary delineation on CBCT. The aim this work was analyze evaluate contouring uncertainties images prospective fashion. Methods Five...
A major problem of current cancer research and therapy is prediction tumor recurrence after initial treatment, rather than the simple biological characterization malignancy proliferative properties tumors. Breast conservation (BCT) a well-approved, standard treatment for patients with early stages breast cancer, which consists lumpectomy whole-breast irradiation. In spite extensive studies, only 'age' 'Ki-67 positivity' have been identified to be well correlated local BCT. An Arf6 pathway,...
BackgroundIn Real-time-image Gated spot-scanning Proton Therapy (RGPT), the dose distribution is distorted by gold fiducial markers placed in prostate. Distortion can be suppressed using small and more than two fields, but additional fields may increase to organs at risk. Therefore, we conducted a prospective study evaluate safety short-term clinical outcome of RGPT for prostate cancer.MethodsBased on previously reported frequency early adverse events (AE) non-inferiority margin 10%,...
PurposeThis treatment planning study was conducted to determine whether spot scanning proton beam therapy (SSPT) reduces the risk of grade ⩾3 hematologic toxicity (HT3+) compared with intensity modulated radiation (IMRT) for postoperative whole pelvic (WPRT).Methods and materialsThe normal tissue complication probability (NTCP) HT3+ used as an in silico surrogate marker this analysis. IMRT SSPT plans were created 13 gynecologic malignancy patients who had received hysterectomies. The...
A 300 kbit bubble memory chip has been designed based on 3 μm technology. Nominal circuit period is 14 and size 9.8 mm×9.6 mm. gap-tolerant design fully employed, such as, asymmetric half-disk propagation pattern, transfer gate, a novel asymmetric-chevron stretcher, etc. The fabricated using new planar process solving step-coverage problems to achieve good yield. typical bias field margin of 18 Oe obtained at 55 with triangular wave drive.
The purpose of this study is to evaluate the clinical results treatment with a high dose 3-dimensional conformal boost (3DCB) using real-time tracking radiation therapy (RTRT) system in cervical cancer patients.Between January 2001 and December 2004, 10 patients were treated 3DCB RTRT system. Nine received whole pelvis (RT) median 50 Gy (range, 40-50 Gy) before 3DCB. was 30 25-30 Gy). Eight twice week daily fraction 5 Gy. determined endpoints tumor response, overall survival, local failure...
Current adaptive and dose escalating radiotherapy for muscle invasive bladder cancer requires knowledge of both inter-fractional intra-fractional motion the wall involved. The purpose this study is to characterize inter- movement partial using implanted fiducial markers a real-time tumor-tracking system.Two hundred fifty one sessions with 29 patients were analysed. After maximal transurethral tumor resection 40 Gy whole irradiation, up six gold transurethrally into around bed used positional...
To investigate the clinical significance of adaptive radiotherapy (ART) in locally advanced nasopharyngeal carcinoma treated with intensity-modulated (IMRT).
This is a report of single-institution prospective study evaluating the safety spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam therapy (PBT) system. Data collection was performed for 56 patients with 59 treatment sites who received at Hokkaido University Hospital between March 2014 and July 2015. Forty-one were male 15 female. The median age 66 years. primary lesion prostate (n = 17), bone/soft tissue 10), liver 7), lung 6), central nervous system 5), colon...
To examine the clinical features of radiation cataract in patients with ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma.Twenty-one 26 eyes diagnosed MALT lymphoma (26 eyes), who were treated Hokkaido University Hospital, retrospectively reviewed based on medical records.Out 21 patients, 16 (21 eyes) received therapy (RT) a total dose 30 Gy. All cases eventually achieved complete remission. Eight these (11 eyes: 52.3%) required surgery after RT. The mean age at was 56.8...
Overexpression of clusterin (CLU), an antiapoptotic molecule, has been reported to induce resistance radiotherapy (RT) in a variety cancer cell types. The aim this study was evaluate the significance CLU expression predict survival patients with advanced-stage cervical who received curative intended RT.Biopsy tissue specimens before RT were obtained from 34 treated at Hokkaido University Hospital between 1998 and 2008 whose complete medical records available. protein analyzed by...
ObjectiveThe real-time tumor-tracking radiotherapy system with fiducial markers has the advantage that it can be used to verify localization of during radiation delivery in real-time. We conducted a prospective Phase II study image-guided local-boost for locally advanced bladder cancer using positioning, and here we report results regarding safety efficacy technique.
BackgroundThe current study was designed to evaluate the clinical outcomes of curative intent radiation therapy for young patients with invasive uterine cervical carcinoma in Japan.
Abstract Background The Graded Prognostic Assessment for lung cancer using molecular markers (Lung-molGPA) has not been validated use with Japanese non-small cell (NSCLC) patients brain metastasis (BM) and the factors impacting survival need to be assessed. Methods We retrospectively analyzed 294 NSCLC who were newly diagnosed BM between 2013 2020 had received radiotherapy initially at Hokkaido Cancer Center. evaluated effect on prognosis of Lung-molGPA items, expression PD-L1 (classified as...