A5027240032- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Cardiac Arrest and Resuscitation
- Viral Infections and Immunology Research
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Renal Transplantation Outcomes and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiovascular Issues in Pregnancy
- Organ and Tissue Transplantation Research
- Polyomavirus and related diseases
- Infective Endocarditis Diagnosis and Management
- Organ Transplantation Techniques and Outcomes
- Fuel Cells and Related Materials
- Pneumocystis jirovecii pneumonia detection and treatment
- Coronary Interventions and Diagnostics
- Public Administration and Political Analysis
- Coronary Artery Anomalies
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Neurogenetic and Muscular Disorders Research
National Cerebral and Cardiovascular Center
2016-2025
Cedars-Sinai Smidt Heart Institute
2020-2023
Cedars-Sinai Medical Center
2020-2023
Massachusetts General Hospital
2021
Hospital Universitario La Paz
2021
Hartford Financial Services (United States)
2021
Amyloidosis Foundation
2021
Research Network (United States)
2021
National Heart Foundation of Australia
2021
Montefiore Medical Center
2021
Marked sarcomere disorganization is a well-documented characteristic of cardiomyocytes in the failing human myocardium. Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v), which involved development cardiomyopathy, an important structural protein that affects physiologic cardiac formation and heart development. Integrated cDNA expression analysis myocardia uncovered novel kinase, cardiac-specific myosin kinase (cardiac-MLCK), acts on MLC2v. Expression levels...
Allosensitization represents a major barrier to heart transplantation (HTx). We assessed the efficacy and safety of complement inhibition at transplant in highly sensitized recipients. performed single-center, single-arm, open-label trial (NCT02013037). Patients with panel reactive antibodies (PRA) ≥70% pre-formed donor-specific (DSA) were eligible. In addition standard care, patients received nine infusions eculizumab during first 2 months posttransplant. The primary composite endpoint was...
Background— Adenosine inhibits proliferation of cardiac fibroblasts and hypertrophy cardiomyocytes, both which may play crucial roles in remodeling. In the present study, we investigated whether chronic stimulation adenosine receptors begun after myocardial infarction (MI) prevents Methods Results— MI was produced Wistar rats by permanent ligation left anterior descending coronary artery. One week onset MI, animals were randomized into 8 groups: vehicle, dipyridamole (DIP; uptake inhibitor,...
Patients with fulminant myocarditis (FM) often present cardiogenic shock and require mechanical circulatory support, including extracorporeal membrane oxygenation (ECMO) ventricular assist device (VAD) implantation. This study sought to clarify the determinants of successful weaning from ECMO in FM patients.We studied 37 consecutive patients supported by as initial form support between January 1995 December 2014 our hospital. Twenty-two (59%) were successfully weaned ECMO, while 15 (41%)...
Objective Little has been reported on the relationship between left main coronary artery atherosclerosis and carotid ultrasonographic results. We evaluated association assessed by intravascular ultrasonography (IVUS) in 45 patients. Methods counted number of plaques with intima-media thickness (IMT) greater than or equal to 1.1 mm calculated a plaque score summing all thicknesses. With use IVUS, percent area was at proximal, middle, distal sites artery. The maximum mean 3 were also...
AIaortic insufficiency ARB angiotensin II receptor blocker
The influence of preexisting donor-transmitted atherosclerosis (DA) on cardiac allograft vasculopathy (CAV) development remains unclear.
Fulminant myocarditis with cardiogenic shock requires extracorporeal life support (ECLS) and has poor outcomes. To improve outcomes, we have converted patients severely impaired cardiac multiorgan function from peripheral to central ECLS. In this study, reviewed these patients' clinical outcomes investigated associated factors.We retrospectively studied 70 consecutive fulminant under 2006 2020. Forty-eight underwent surgical conversion support, the remaining continued support. The end point...
Although right heart failure (RVF) is an important issue in the management of patients with left ventricular assist devices (LVADs), benefits performing tricuspid valve repair conjunction LVAD implantation have not been demonstrated. We retrospectively reviewed records 141 who received as a bridge to transplant from May 1999 January 2013. assessed short- and long-term function 69 these underwent because moderate-to-severe regurgitation (TR) or severe dilatation annulus. RVF was defined need...
An accurate and rapid pathologic diagnostic in fulminant myocarditis is crucial for appropriate therapeutic decision-making. Since giant cells can appear various conditions, careful judgment based on repeated imaging, pathological analysis, close clinical follow-up essential to make precise decisions. A previously healthy 36-year-old woman was admitted the hospital with haemodynamic compromise requiring mechanical circulatory support. Pathologic findings of left ventricular (LV) at time...
In the present study, intravascular ultrasound (IVUS) morphologic appearance of coronary atherosclerotic plaque associated with focal spasm was prospectively studied in 45 patients or without provoked by ergonovine acetylcholine. The percent area and arc were determined from IVUS images at sites spasm. Calcified lesion defined as presence high-intensity echo acoustic shadowing. Twenty-three had angiographic narrowing >75% demonstrated these 23 sites. 22 spasm, 18 lesions 17 remaining 5 did...
The effects of left ventricular assist system (LVAS) implantation on renal hemodynamics remains to be fully elucidated. We evaluated function and intrarenal blood flow in five advanced heart failure patients who had been supported with a Toyobo LVAS for bridge transplantation. Renal expressed as estimated glomerular filtration rate (eGFR) was calculated using the modified formula Modification Diet Disease. Mean velocities bilateral segmental arteries during systolic diastolic perfusion were...
Mechanical circulatory support by a left ventricular assist device (LVAD) is used to bridge patients with advanced heart failure transplant or as definitive treatment. We retrospectively sought predictors of long-term outcome in cohort 83 who had undergone LVAD subjected perioperative clinical data statistical analysis establish parameters associated all-cause mortality, and the cutoff values, sensitivity, specificity those that statistically significant relation survival. Mean follow-up was...
Cardiac allograft vasculopathy (CAV) limits long-term success after heart transplant. We assessed the post-transplant risk factors for CAV development.Patients who underwent transplant between May 1999 and December 2013 were included in this study. Patients (n=54) divided into 2 groups according to presence or absence of progression Coronary angiogram intravascular ultrasound conducted within 5-11 weeks transplant, at 12 months, annually thereafter. Scheduled endomyocardial biopsies...
Abstract Aims Cardiac myosin light chain kinase (cMLCK) phosphorylates ventricular regulatory 2 (MLC2v) and regulates sarcomere cardiomyocyte organization. However, few data exist regarding the relationship between cMLCK mutations MLC2v phosphorylation, particularly in terms of developing familial dilated cardiomyopathy (DCM) whom gene were identified. The purpose present study was to investigate functional consequences DCM patients. Methods results diagnosis based on patients' history...
There is an adult patient population in Japan with undiagnosed coronary artery lesions caused by Kawasaki disease (KD) occurring before 1967, the time at which KD was first described. Two patients presented a low left ventricular (LV) ejection fraction and tachycardia (VT) presumed KD. A 43-year-old man rapid VT had history of acute febrile illness desquamation fingertips age 10 months. Coronary angiography (CAG) showed segmental stenosis right (RCA) occlusion anterior descending giant...