This study investigated signal transduction in T-lymphocytes, whose cell receptors are categorized into several groups based on their signaling mechanisms and the intracellular biochemical pathways they activate, including modular proteins adapter molecules that perform scaffolding or catalytic functions. Adapter facilitate complexes by linking various enzymes. Immune receptors, which composed of integral membrane from immunoglobulin superfamily, interact with specific tyrosine-containing...

To study the structure, risk factors and methods of prevention postoperative brain dysfunction on example coronary artery bypass surgery with cardiopulmonary bypass.The included 77 patients who undergone elective at beating heart (22 patients) or (55 patients, including 24 received cerebroprotective treatment cytoflavin in preoperative period). All underwent dynamic (pre- postoperative) neurological, neuropsychological, instrumental examinations.The cerebral was diagnosed 34 (44,2%)...

In 2020 the whole world was faced with an epidemiological outbreak caused by a new coronavirus SARS-CoV-2. The information available to date suggests that newly isolated SARS-CoV-2 should be assigned superantigens, main manifestations of which, as it is known, are suppression nonspecific resistance factors and innate immunity mechanisms associated formation systemic inflammatory response in form cytokine storm pathological activation phagocytes lung tissue its alteration subsequent fibrosis....

The results of three-year research on the use allogeneic mesenchymal stem cells adipose tissue (AMSCs) in treatment skin burns II-III degree are presented. a complex with wounds dressing nanofibers chitosan and copolyamide, hyaluronic acid. It was found that surgical necrectomy, introduction AMSCs substitution defects natural polymer coatings, healing time is reduced by 89% (p < 0.05). Isolated administration MSC reduces period no more than 5% > combined dressings copo lyamide...

The aim of the study was to develop a method for diagnosing pre-nosological changes in electrophysiological state myocardium patients with somatoform dysfunction autonomic nervous system (SDANS) and risk factors cardiovascular diseases using ECG dispersion mapping method.The involved 109 male patients, 58 them SDANS, 51 were healthy subjects. SDANS had following diseases, decreasing order: stress (71% cases), low physical activity (59%), smoking (57%), overweight obesity (43%), anxiety...

The possibility of neural tissue regeneration in encephalopathies various genesis by influencing brain cell pool with reduced functional activity the state parabiosis is discussed. use a neuroprotective agent rekognan (citicoline) justified etiopathogenetic therapy realizing its effects through mechanisms synthesis membrane phospholipids, inhibition phospholipase A2, restoration Na+/K+-adenosine triphosphate functioning, blocking oxidative stress and apoptosis, modulation choline, dopamine...

The role sialic acids in maintenance of an immune homeostasis is considered. It known, that development both cleanly nonspecific protective effects, and specific, microbes agents providing interaction with specific receptors immunocompetent cells peculiar to acids. Sialic represent components cellular receptors, which are viruses family Adenoviridae, Reoviridae, Orthomyxoviridae for many gram-positive bacteria. facts reflecting the major stability a macroorganism pathogenes various nature,...

The main biological characteristics of viruses the Coronaviridae family are presented. features immunopathogenesis these infections analyzed. It was found that structural proteins spine, membrane, envelope and nucleocapsid play an important role in COVID-19 infection. They associated with hyperactivation neutrophils monocytes-macrophages, secreting large amounts pro-inflammatory cytokines chemokines. This contributes to development a cytokine storm unfavorable prognosis disease. A...

The results of the evaluation effectiveness using inosine glycyl-cysteine-glutamate disodium (Molixan) in acute severe poisoning with ethanol are presented 57 cases hospitalized patients (males) I or II stage alcoholic coma were investigated. Patients control group 27 people received only basic therapy alcohol poisoning. 30 from main addition to moliksan drug at a dose 3 mg/kg intravenously. Laboratory indicators metabolic acidosis, which developed both groups, included by significant blood...

Актуальность. К числу разнообразных кислородзависимых патологических состояний относят, в том числе, интермиттирующие, волнообразно протекающие эпизоды гипоксии, чередующиеся с пребыванием человека условиях нормоксии. Примером подобных является сонное апноэ. Особенности метаболизма при таких состояниях практически не изучались, что и определяет актуальность исследования. Цель исследования: выявить особенности у лабораторных животных, подвергающихся хроническому волнообразному кислородному...

Статья посвящена анализу массива научных публикаций выдающегося патофизиолога академика Виктора Константиновича Кулагина. Цель сообщения – раскрыть и подчеркнуть вклад В.К. Кулагина в разработку учения о травме шоке. Анализ показал, что основными аспектами экспериментальных исследований ученого были нейрогуморальные механизмы развития травматического шока, различия шока при кровопотере, роль нарушений функций эндокринной системы (гипофиз, кора надпочечников) значение изменений ряда...

The article presents the history of nascence traditional oriental medicine in Russia during XVIII–XIX centuries. first information about was brought to XVIII century by doctors, who visited Mongolia and China as members embassy expeditions. decades can be considered beginning a systematic study treatment methods. It possible thanks many years efforts employees Russian ecclesiastical mission Beijing. This organization from 1715 1864 served religious, diplomatic scientific functions. An...

The role of myostatin in the development sarcopenia patients receiving programed hemodialysis and severity relationship with other risk factors, particularly between level blood skeletal muscle indicators, were analyzed. A single-stage prospective non-interventional study was conducted among 196 (97 women 99 men, aged 54–66 years) hemodialysis. After signing informed consent form, all underwent a series examinations consisting assessment anthropometric data, measurement vital signs,...

The state of the arterial vascular endothelium against background subclinical atherosclerosis and its relationship with gene polymorphism in military personnel serving Arctic climatic zone, depending on duration service, was evaluated. In total, 251 male servicemen aged 28–40 years were examined. group climate zone included 99 people, who divided into three groups according to service Arctic: 1 8 (8%) up 5 service; 2, 21 (21%) people 5–10 years; 3, 70 (71%) 10 years. control 152 from...

Aim. Тo train future specialists to effectively apply the methods of pathophysiological research (ultrasound diagnostics) in solving situational problems within course clinical pathophysiology. Materials and methods. The 2 nd 3 rd year students were trained use stationary portable ultrasound machines Phillips CX50 Chison Sonotouch 80. master B M modes, Doppler ultrasonography, as well elastography most common diseases endocrine, digestive, urinary systems. At first stage, worked tandem with...

One of the main molecular mechanisms viroids that cause disease in plants is blocking ribonucleic acid functions host cells by viroid acid. The variety splicing options due to replication, which requires polymerase, ribonuclease, ligase, and deoxyribonucleic working on matrices. Viroids with faster replication are preferred. Identifying proteins interact critical pathogenesis infections, leads gene expression changes plants. study plant infections caused satellite viruses has shown they have...

Activation of the body’s regulatory systems provides adaptation to impact pathogenic factors. Prolonged exposure extreme factors during combat operations can lead formation a focus pathologically increased exaltation in central nervous system. The study aims comparatively assess tension structures victims with battle and peacetime traumas acute period develop criteria for indicating severity functional disorders system pathogenetic treatment. Twenty servicemen who received mine-explosive...

The study aims to determine how the reactivity of autonomic nervous system contributes body’s multidrug resistance adverse environmental effects. Volunteers were subjected hypoxia simulation in an altitude chamber at 4 500 m and hyperthermia by being exposed a heating microclimate (40°, humidity 60–70 %). A spectral analysis heart rhythm was used during 5-minute continuous ECG recording assess characteristics regulation. Regular changes frequencies amplitudes leading peaks Fourier rate...

The article presents the history of development traditional oriental medicine in Russia and USSR 20th century. Information about Eastern obtained century thanks to employees doctors Russian Ecclesiastical Mission Beijing has been repeatedly analyzed rethought. A great contribution understanding methods treatment was translation Zhud-shi made by P.A. Badmaev. At beginning century, V.V. Korsakov Ya.A. Violin defended dissertations on Chinese at Military Medical Academy. In 1948, outstanding...

The results obtained and conflicting data of immunopathogenesis inflammation atherosclerosis are analyzed. role macrophages T-lymphocytes in the endothelium damage formation an atherosclerotic plaque is shown. Chemokine-leading processes initiating - macrophage chemotactic protein, interleukin 8, fractalkine. An important initiation intercellular interaction with subsequent development alliance CD40 their ligands, expressed by various cell types, participants immune-inflammatory process...

The article considers immune dysfunction in military personnel participating special operations and the possibilities of their medical psychological rehabilitation. state status 73 servicemen (average age 37.6 4.1 years) who participated areas with a difficult operational situation underwent 20-day standard course rehabilitation sanatoriums sanatorium complexes North Caucasian, Sochi, Crimean was monitored. Immune assessed before after participation due to quantitative functional changes...

Features of organization and functioning pattern-recognizing receptors signaling pathways in induction antiviral immune response are considered. The recognition antigenic structures the virus is carried out by pathogen-associated molecular patterns innate immunity cells. These Toll-like receptors, nucleotide-binding oligomerization domain-like lectin C-type RIG-I-like receptors. these receptor depends on protein molecules that provide activation signals. adapter proteins primary myeloid...