Alper Köker

ORCID: 0000-0003-1231-3023
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About
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Research Areas
  • Cardiac Arrest and Resuscitation
  • Clinical Nutrition and Gastroenterology
  • Hemoglobinopathies and Related Disorders
  • Nutrition and Health in Aging
  • Emergency and Acute Care Studies
  • Trauma and Emergency Care Studies
  • Central Venous Catheters and Hemodialysis
  • Sepsis Diagnosis and Treatment
  • Antifungal resistance and susceptibility
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Iron Metabolism and Disorders
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Infectious Encephalopathies and Encephalitis
  • Hemodynamic Monitoring and Therapy
  • Electrolyte and hormonal disorders
  • Nosocomial Infections in ICU
  • Intestinal Malrotation and Obstruction Disorders
  • Renal function and acid-base balance
  • Intensive Care Unit Cognitive Disorders
  • Ultrasound in Clinical Applications
  • Disaster Response and Management
  • Epilepsy research and treatment
  • Bone and Joint Diseases
  • Metabolism and Genetic Disorders
  • Acute Kidney Injury Research

Akdeniz University
2022-2025

Akdeniz University Hospital
2024

Dokuz Eylül University
2017-2023

Intensive Care Foundation
2023

Sivas State Hospital
2021

State Hospital
2020

Sağlık Bilimleri Üniversitesi
2020

Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi
2020

Rize Devlet Hastanesi
2019

Konya Eğitim ve Araştırma Hastanesi
2014

Background: The inability to ensure adequate nutrition for patients, and failure provide calorie protein intake, result in malnutrition, leading increased morbidity mortality. present study assesses the two approaches enteral nutrition—intermittent continuous feeding—in critically ill pediatric patients Türkiye determine superiority of one method over other. Methods: Included this multicenter prospective were receiving via a tube who followed up 3-month period. Anthropometric data, signs...

10.3390/nu17020301 article EN Nutrients 2025-01-15

This study addresses the characteristics, kidney replacement therapy (KRT) modalities, and outcomes in children diagnosed with crush syndrome following an earthquake Turkey. To analyze associations of different KRT modalities long-term dialysis dependency length stay (LOS) pediatric intensive care unit (PICU). multicenter, prospective, retrospective cohort was conducted across 20 PICUs Participants included after 2023 Kahramanmaraş earthquake, eligibility criteria age, diagnosis, need for...

10.1001/jamanetworkopen.2024.56793 article EN cc-by-nc-nd JAMA Network Open 2025-01-27

Introduction Malnutrition is defined as a pathological condition arising from deficient or imbalanced intake of nutritional elements. Factors such increasing metabolic demands during the disease course in hospitalized patients and inadequate calorie increase risk malnutrition. The aim present study to evaluate status admitted pediatric intensive care units (PICU) Turkey, examine effect nutrition on treatment process draw attention need for regulating support while continuing existing...

10.3389/fped.2023.1179721 article EN cc-by Frontiers in Pediatrics 2023-08-03

Aim Although early enteral nutrition (EN) is strongly associated with lower mortality in critically ill children, there no consensus on the definition of EN. The aim this study was to evaluate our current practice supplying EN and identify factors that affect both initiation feeding within 24 h after paediatric intensive care unit (PICU) admission adequate supply first 48 PICU children. Methods We conducted a prospective, multicentre, observational nine PICUs Turkey. Any kind tube commenced...

10.1111/jpc.13810 article EN Journal of Paediatrics and Child Health 2017-12-26

Definition of Continuous Renal Replacement Therapies and Methods UsedContinuous renal replacement therapies are extracorporeal support systems in which solute and/or water clearance is achieved the time desired by clinician using dialysis (diffusion-based removal) filtration (convectionbased methods. 3Terminology 1. Route; vascular access necessary for blood flow to reach system Venovenous route -This a method that does not require arterial access.Two separate catheters placed two veins or...

10.4274/cayd.galenos.2023.71677 article EN cc-by-nc Turkish Journal of Pediatric Emergency and Intensive Care Medicine 2024-04-01

Introduction Pediatric traumatic brain injury (TBI) is a significant cause of death and long-term disability. There paucity data on quality life in survivors pediatric TBI. The aim this study to determine the factors affecting after TBI children. Methods Consecutively admitted 104 156 patients intensive care unit (PICU) with between 1 month 18 years were included study. Demographics obtained from electronic records. Injury severity mortality scores calculated. Quality Life Inventory (PedsQL)...

10.1055/s-0042-1758475 article EN Journal of Pediatric Intensive Care 2022-11-11

Sevoflurane is a volatile anesthetic agent that does not tend to cause clinically significant hepatotoxicity, but there are some reported hepatotoxicity cases in the literature. In case presented here, adenotonsillectomy was performed during influenza infection, and sevoflurane administered, after which acute fulminant hepatitis developed. At hour 24 of hospitalization hepatic failure, liver transplant 3.5-year-old patient without any known diseases. such cases, etiology investigations...

10.6002/ect.2022.0386 article EN Experimental and Clinical Transplantation 2023-06-01

Hemophagocytic lymphohystiocytosis (HLH) may be primary (inherited/familial) or secondary to infections, malignancies, rheumatologic disorders, immune deficiency syndromes and metabolic diseases.Cases including lysinuric protein intolerance, multiple sulfatase deficiency, galactosemia, Gaucher disease, Pearson syndrome, galactosialidosis have previously been reported.It is unclear how the metabolites trigger HLH in diseases.A 2-month-old infant with lethargy, pallor, poor feeding,...

10.5546/aap.2020.eng.e174 article EN Archivos Argentinos de Pediatria 2020-02-01

Deficiency of vitamin B12, with an essential role in cellular metabolism, is commonly observed Turkey (Koc A et al., Eur J Nutr 2006; 45: 291–297). The most common cause B12 deficiency insufficient intake the diet. Due to strict vegan diets or pernicious anemia, it among breastfed infants mothers low levels. Mothers are generally asymptomatic. affected continue have healthy development for first 6 months due available hepatic stocks, but if continues irritability, nutritional problems,...

10.1055/a-0981-6355 article EN Klinische Pädiatrie 2019-08-13

The clinical presentation of Non-Hodgkin lymphoma (NHL) is frequently associated with the involvement abdomen and mediastinal lymphadenopathies, but rarely kidney, ovaries, testicles. Here, we report a rare case T-cell lymphoblastic (T-LBL) presenting bilateral nephromegaly without acute renal failure (ARF) as first manifestation. A 30-month-old boy was admitted to department pediatric nephrology exhibiting abdominal distension. Physical examination revealed palpation up inguinal region....

10.1155/2019/2802141 article EN cc-by Case Reports in Hematology 2019-12-10

Objective: Candida species are the most common infectious agents among pathogens responsible for nosocomial fungal infections. Transmissions in intensive care units account a significant proportion of mortality and morbidity associated with candida The present study evaluates prevalence, type, treatment approach, underlying risk factors, outcomes infections patients treated pediatric unit Türkiye dense population children who have fled war Syria. Methods: was conducted 14-bed tertiary city...

10.59213/tp.2023.37450 article EN cc-by Trends in Pediatrics 2023-03-15

We aimed to assess the effect of continuous drainage subglottic secretion in prevention ventilator-associated pneumonia (VAP) patients requiring prolonged mechanical ventilation for more than 48 hours ICU as a prospective, randomized, controlled study.

10.1186/cc13521 article EN cc-by Critical Care 2014-03-17

Background. A significant number of children are injured by or die from firearm-related incidents every year, although there is a lack global data on the admitted to pediatric emergency departments (PEDs) and intensive care units (PICU) with firearm injuries. This study most comprehensive analysis injuries sustained in Turkey date. Methods. multicenter, retrospective, cohort was conducted between 2010 2020 contributions PEDs, PICUs, units, surgery university hospitals research hospitals....

10.24953/turkjped.2021.4564 article EN cc-by The Turkish Journal of Pediatrics 2022-12-25

Background: Congenital afibrinogenemia is characterized by the absence of fibrinogen. fibrinogen disorders result from several mutations in FGA , FGB or FGG . Their epidemiology not well known. Observation: The present study reports on 2 children with congenital afibrinogenemia. first child, a male who now 9 years old, was diagnosed after spontaneous intracranial bleeding at age 3 years. second child 2-year-old female cousin patient, coagulation tests were carried out due to frequent...

10.1097/mph.0000000000001658 article EN Journal of Pediatric Hematology/Oncology 2019-11-12

Introduction:Although nutrition is very effective on mortality in critically ill children, patients cannot be fed adequately.There no suitable biomarker for enteral monitoring and management.The aim of this study; To investigate the usability nefsatin-1 nutritional management children. Methods:In January-September 2019 period, 35 children who were hospitalized tertiary pediatric intensive care unit without any signs inflammation included study.Nesfatin-1, vitamin D level, prealbumin, albumin...

10.4274/cayd.galenos.2022.07830 article EN cc-by-nc Turkish Journal of Pediatric Emergency and Intensive Care Medicine 2023-03-09
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