This study examined the associations of body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), and physical activity (PA) with gray matter cerebral blood flow (CBFGM) in older adults. Cross-sectional data was used from Irish Longitudinal Study on Ageing (n = 495, age 69.0 ±7.4 years, 52.1% female). Whole-brain CBFGM quantified using arterial spin labeling MRI. Results multivariable regression analysis revealed that an increase BMI 0.43 kg/m2, WHR 0.01, or WC 1.3 cm were...

Abstract Background Cognitive reserve is most commonly measured using socio-behavioural proxy variables. These variables are easy to collect, have a straightforward interpretation, and widely associated with reduced risk of dementia cognitive decline in epidemiological studies. However, the specific proxies vary across studies rarely been assessed complete models (i.e. alongside both measure outcome brain structure). Complete can test independent associations between function addition...

To establish normative reference values for total grey matter cerebral blood flow (CBFGM) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged 54 years and older. Quantitative assessment CBFGM may provide an imaging biomarker the early detection those at risk neurodegenerative diseases, such as Alzheimer's dementia. However, use this method to differentiate normal age-related decline from pathological reduction has been...

This study explores the relationship of life-course intergenerational social mobility with cognitive function and brain structure in older adults using Diagonal Reference Models. Data from Irish Longitudinal Study on Ageing, a population-based cohort aged 50 years (N = 4 620 participants; mean age: 66.1; standard deviation: 9.1; 55% female) was used for analysis. Brain magnetic resonance imaging data were available 464 participants. Social characterized as difference between childhood...

Fried's frailty phenotype (FP) is defined by exhaustion (EX), unexplained weight loss (WL), weakness (WK), slowness (SL) and low physical activity (LA). Three or more components define the frail state, one two prefrail. We described longitudinal transitions of FP states in The Irish Longitudinal Study on Ageing (TILDA). included participants aged ≥50 years with information at TILDA wave 1 (2010), who were followed-up over four waves (2012, 2014, 2016, 2018). Next-wave transition...

Cognitive reserve supports cognitive function in the presence of pathology or atrophy. Functional neuroimaging may enable direct and accurate measurement which could have considerable clinical potential. The present study aimed to develop validate a measure using task-based fMRI data that then be applied independent resting-state data. Connectome-based predictive modelling with leave-one-out cross-validation was predict residual functional connectivity from Reserve/Reference Ability Neural...

Abstract Purpose Sarcopenia and delayed orthostatic blood pressure (BP) recovery are two disorders increasingly associated with adverse clinical outcomes in older adults. There may exist a pathophysiological link between the via skeletal muscle pump of lower limbs. Previously large population-based study, we found an association probable sarcopenia BP recovery. Here, sought to determine confirmed falls clinic attendees aged 50 years or over. Methods One hundred nine recruited patients (mean...

This study investigates the relationship between white matter hyperintensities (WMHs) and longitudinal cognitive decline in older adults. Using data from The Irish Longitudinal Study on Ageing (TILDA), we examined WMH characteristics, including volume, location, microstructural integrity, a community-dwelling population of 497 individuals over six-year period. WMHs were categorised into phenotypes based their size, fractional anisotropy (FA), mean diffusivity (MD), with subtypes for...

Falls and fractures are common among older people. The Screening Tool of Older Persons Prescriptions in adults with high fall risk (STOPPFall) provides a comprehensive list fall-risk-increasing drugs (FRIDs). This study assesses the association between STOPPFall medications future falls/fractures large cohort community-dwelling people ≥65 years using Irish Longitudinal Study on Ageing (TILDA) Waves 1-6, collected from 2009 to 2021. were recorded at Wave 1 3. Falls/fractures self-reported....

Due to its cardiovascular effects sedentary behaviour might impact cerebrovascular function in the long term, affecting regulatory mechanisms and perfusion levels. Consequently this could underly potential structural brain abnormalities associated with cognitive decline. We therefore assessed association between measures of community-dwelling older adults. Using accelerometery (GENEActiv) data from The Irish Longitudinal Study on Ageing (TILDA) we categorised individuals by low-...

Assessment of the cerebrovascular and cardiovascular response to standing has prognostic value for a range outcomes in older adult population. Studies generally attempt control speed differences by asking participants stand specified time but little is known about transition times observed. This study aimed characterize how associates with measures following from supine standing. Continuous cerebral oxygenation, heart rate, systolic diastolic blood pressure were monitored 3 minutes after...

Abstract Study Objectives This study examines the cross-sectional and 2-year follow-up relationships between sleep stress total hippocampal volume subfield volumes among older adults. Methods Four hundred seventeen adults (aged 68.8 ± 7.3; 54% women) from Irish Longitudinal on Ageing completed an interview, a questionnaire, multiparametric brain magnetic resonance imaging. The self-reported duration, problems, perceived stress, were examined by using ordinary least squares regressions....

Frailty in older adults is associated with greater risk of cognitive decline. Brain connectivity insights could help understand the association, but studies are lacking. We applied connectome-based predictive modeling to a 32-item self-reported Index (FI) using resting state functional MRI data from The Irish Longitudinal Study on Ageing. A total 347 participants were included (48.9% male, mean age 68.2 years). From modeling, we obtained 204 edges that positively correlated FI and composed...

Frailty in older adults has been associated with reduced brain health. However, structural signatures of frailty remain understudied. Our aims were: (1) Explore associations between a index (FI) and structure on magnetic resonance imaging (MRI). (2) Identify the most important FI features driving associations.

One possible contributing factor for cerebral blood flow (CBF) decline in normal aging is the increase partial volume effects due to brain atrophy, as cortical thinning can exacerbate contamination of gray-matter (GM) voxels by other tissue types. This work investigates CBF changes a large elderly cohort aged 54 84 and how correction that would accommodate potential GM might affect this. The study consisted 474 participants years using pseudo-continuous arterial spin labeling MRI. A...

The quantification of biological age in humans is an important scientific endeavor the face ageing populations. frailty index (FI) methodology based on accumulation health deficits and captures variations status within individuals same age. aims this study were to assess whether addition FI improves its mortality prediction associations individual items differ strength. We utilized data from Irish Longitudinal Study Ageing conduct, by sex, machine learning analyses ability a 32-item predict...

In this cross-sectional study, the relationship between noninvasively measured neurocardiovascular signal entropy and physical frailty was explored in a sample of community-dwelling older adults from The Irish Longitudinal Study on Ageing (TILDA). hypothesis under investigation that dysfunction neurovascular cardiovascular systems, as quantified by short-length complexity during lying-to-stand test (active stand), could provide marker for frailty. Frailty status (i.e., “non-frail”,...

Multisensory perception might provide an important marker of brain function in aging. However, the cortical structures supporting multisensory aging are poorly understood. In this study, we compared regional gray matter volume a group middle-aged (n = 101; 49-64 years) and older 116; 71-87 adults from The Irish Longitudinal Study on Aging using voxel-based morphometry. Participants completed measure integration, sound-induced flash illusion, were grouped as per their illusion susceptibility....

To investigate whether tooth loss and related of occluding pairs, were associated with cognitive decline in a group community dwelling older men women from Ireland.A 2508 women, aged 50-93 years, underwent dental examination as part The Irish Longitudinal Study ageing (TILDA). Global function was assessed using the mini-mental state (MMSE). Analysis included multiple logistic regression adjustment for various confounders.The mean age participants 65.5 years (SD 8.1) 55.3% female. Three...

We examined the relationship between hippocampal subfield volumes and cognitive decline over a 4-year period in healthy older adult population with goal of identifying subjects at risk progressive impairment which could potentially guide therapeutic interventions monitoring. 482 (68.1 years +/− 7.4; 52.9% female) from Irish Longitudinal Study on Ageing underwent magnetic resonance brain imaging series tests. Using K -means longitudinal clustering, were first grouped into three separate...

<ns3:p><ns3:bold>Background</ns3:bold>: The frailty index (FI) is based on accumulation of health deficits. FI cut-offs define non-frail, prefrail and frail states. We described transitions states in Irish Longitudinal Study Ageing (TILDA).</ns3:p><ns3:p> <ns3:bold>Methods</ns3:bold>: Participants aged ≥50 years with information for a 31-deficit at wave 1 (2010) were followed-up over four waves (2012, 2014, 2016, 2018). Transitions visualized alluvial plots probabilities estimated...

Abstract Background Orthostasis is a potent physiological stressor which adapts with age. The age-related accumulation of health deficits in multiple systems may impair the response to orthostasis and lead negative outcomes such as falls, depression, cognitive decline. Research date has focused on changes at prespecified intervals time, without consideration for whole signal approaches. Methods One-dimensional statistical parametric mapping identified regions time significant association...