A5059630861- Phonetics and Phonology Research
- Dementia and Cognitive Impairment Research
- Speech and dialogue systems
- Health disparities and outcomes
- Functional Brain Connectivity Studies
- Health, Environment, Cognitive Aging
- Language Development and Disorders
- Speech Recognition and Synthesis
- Language, Discourse, Communication Strategies
- Natural Language Processing Techniques
- Reading and Literacy Development
- Psychological Well-being and Life Satisfaction
- Voice and Speech Disorders
- Language, Metaphor, and Cognition
- Blood Pressure and Hypertension Studies
- Frailty in Older Adults
- Sleep and related disorders
- Neurobiology of Language and Bilingualism
- Aging and Gerontology Research
- COVID-19 and Mental Health
- Linguistics and Discourse Analysis
- Health and Well-being Studies
- Multisensory perception and integration
- Advanced Neuroimaging Techniques and Applications
- Employment and Welfare Studies
Trinity College Dublin
2015-2025
Laboratoire Parole et Langage
2008-2017
Aix-Marseille Université
2009-2017
Centre National de la Recherche Scientifique
2009-2014
Centre Hospitalier du Pays d'Aix
2012
Speech Pathology Australia
2011
ObjectivesIt is a concern that public health measures to prevent older people contracting COVID-19 could lead rise in mental problems such as depression.The aim of this study therefore examine trends depressive symptoms before and during the pandemic large cohort people.DesignObservational with 6-year follow-up.Setting & ParticipantsMore than 3000 community-dwelling adults aged ≥60 years participating The Irish Longitudinal Study on Ageing (TILDA).MethodsMixed effects multilevel models were...
This study examined the associations of body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), and physical activity (PA) with gray matter cerebral blood flow (CBFGM) in older adults. Cross-sectional data was used from Irish Longitudinal Study on Ageing (n = 495, age 69.0 ±7.4 years, 52.1% female). Whole-brain CBFGM quantified using arterial spin labeling MRI. Results multivariable regression analysis revealed that an increase BMI 0.43 kg/m2, WHR 0.01, or WC 1.3 cm were...
Abstract Background Cognitive reserve is most commonly measured using socio-behavioural proxy variables. These variables are easy to collect, have a straightforward interpretation, and widely associated with reduced risk of dementia cognitive decline in epidemiological studies. However, the specific proxies vary across studies rarely been assessed complete models (i.e. alongside both measure outcome brain structure). Complete can test independent associations between function addition...
This study explores the relationship of life-course intergenerational social mobility with cognitive function and brain structure in older adults using Diagonal Reference Models. Data from Irish Longitudinal Study on Ageing, a population-based cohort aged 50 years (N = 4 620 participants; mean age: 66.1; standard deviation: 9.1; 55% female) was used for analysis. Brain magnetic resonance imaging data were available 464 participants. Social characterized as difference between childhood...
Cognitive reserve supports cognitive function in the presence of pathology or atrophy. Functional neuroimaging may enable direct and accurate measurement which could have considerable clinical potential. The present study aimed to develop validate a measure using task-based fMRI data that then be applied independent resting-state data. Connectome-based predictive modelling with leave-one-out cross-validation was predict residual functional connectivity from Reserve/Reference Ability Neural...
Age-related sensory decline impacts cognitive performance and exposes individuals to a greater risk of decline. Integration across the senses also changes with age, yet link between multisensory perception ageing is poorly understood. We explored relationship integration function in 2875 adults aged 50 + from The Irish Longitudinal Study on Ageing. Multisensory was assessed at several audio-visual temporal asynchronies using Sound Induced Flash Illusion (SIFI). More precise (i.e. less...
Abstract Background Older adults have both the highest risk of contracting SARS‐CoV‐2 and in many jurisdictions had additional restrictions placed on social interactions. As a result, COVID‐19 pandemic has led to increased depression loneliness among older adults. Using data from an established cohort adults, aims this study was describe changes examine directionality association between over 5‐year period that included early months pandemic. Methods Data were The Irish Longitudinal Study...
Cognitive impairment (CI) affects 40-65% of patients with multiple sclerosis (MS). CI can have a negative impact on patient's everyday activities, such as engaging in conversations. Speech production planning ability is crucial for successful verbal interactions and thus preserving social occupational skills. This study investigates the effect cognitive-linguistic demand speech MS, reflected prosody. A secondary aim to explore clinical potential prosodic features prediction an individual's...
This study investigates the mediating roles of autonomic function and mental health in association between sleep cognitive decline adults aged 50 above.
This study investigates the relationship between white matter hyperintensities (WMHs) and longitudinal cognitive decline in older adults. Using data from The Irish Longitudinal Study on Ageing (TILDA), we examined WMH characteristics, including volume, location, microstructural integrity, a community-dwelling population of 497 individuals over six-year period. WMHs were categorised into phenotypes based their size, fractional anisotropy (FA), mean diffusivity (MD), with subtypes for...
<ns3:p>Background This study examined the Big 5 personality traits as potential sources of heterogeneity in changes depressive symptoms while accounting for pre-pandemic trends symptoms. Methods Data from waves The Irish Longitudinal Study on Ageing (TILDA), including a COVID-19 specific sub-study were included.. Linear mixed effects models fit by maximum likelihood associated with pandemic occurring over time. Results Participants (n=3,404, 56.7% female) aged 50 years and older. In Wave,...
Speech and Language Impairments, generally attributed to lexico-semantic deficits, have been documented in Mild Cognitive Impairment (MCI) Alzheimer's disease (AD). This study investigates the temporal organisation of speech (reflective production planning) reading aloud relation cognitive impairment, particularly working memory attention deficits MCI AD. The discriminative ability features extracted from a newly designed read task is also evaluated for detection AD.Sixteen patients with...
Due to its cardiovascular effects sedentary behaviour might impact cerebrovascular function in the long term, affecting regulatory mechanisms and perfusion levels. Consequently this could underly potential structural brain abnormalities associated with cognitive decline. We therefore assessed association between measures of community-dwelling older adults. Using accelerometery (GENEActiv) data from The Irish Longitudinal Study on Ageing (TILDA) we categorised individuals by low-...
The COVID-19 pandemic in 2020 resulted the older population being asked to remain at home and avoid other people outside their household. This could have implications for both receipt provision of informal caring.To determine if care by carers changed during first wave from pre-pandemic this was associated with a change mental health well-being carers.Longitudinal nationally representative study community dwelling adults Irish Longitudinal Study on Ageing (TILDA) (Waves 3-COVID-Wave 6).We...
Abstract Study Objectives This study examines the cross-sectional and 2-year follow-up relationships between sleep stress total hippocampal volume subfield volumes among older adults. Methods Four hundred seventeen adults (aged 68.8 ± 7.3; 54% women) from Irish Longitudinal on Ageing completed an interview, a questionnaire, multiparametric brain magnetic resonance imaging. The self-reported duration, problems, perceived stress, were examined by using ordinary least squares regressions....
Abstract Objective Cognitive impairment is prevalent in older ages. Associations with sleep are well established; however, ambiguity remains which characteristics contribute to this impairment. We examined cross‐sectional associations between both self‐reported and actigraphy‐based cognitive performance across a number of domains community‐dwelling adults. Methods 1520 participants aged 50 total time (TST) (≤5, 6, 7–8, 9 ≥10 h) problems were analysed. function was assessed using the...
Frailty in older adults is associated with greater risk of cognitive decline. Brain connectivity insights could help understand the association, but studies are lacking. We applied connectome-based predictive modeling to a 32-item self-reported Index (FI) using resting state functional MRI data from The Irish Longitudinal Study on Ageing. A total 347 participants were included (48.9% male, mean age 68.2 years). From modeling, we obtained 204 edges that positively correlated FI and composed...