A5041443749- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Liver Disease and Transplantation
- Hepatitis Viruses Studies and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Artificial Intelligence in Healthcare
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Liver Diseases and Immunity
- Transplantation: Methods and Outcomes
- COVID-19 epidemiological studies
- Hepatocellular Carcinoma Treatment and Prognosis
- interferon and immune responses
- Medical Research and Treatments
- Vaccine Coverage and Hesitancy
- HIV/AIDS oral health manifestations
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatitis Pathology and Treatment
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- Drug-Induced Hepatotoxicity and Protection
Wuxi People's Hospital
2013-2024
Jiangnan University
2018-2024
Wuxi Fourth People's Hospital
2020-2022
Background: Cases of excessive neutrophil counts in the blood severe coronavirus disease (COVID-19) patients have drawn significant attention. Neutrophil infiltration was also noted on pathological findings from autopsy. It is urgent to clarify pathogenesis neutrophils leading pneumonia COVID-19. Methods: A retrospective analysis performed 55 COVID-19 classified as mild (n = 22), moderate 25), and 8) according Guidelines released by National Health Commission China. Trends relating leukocyte...
Introduction: The coronavirus disease 2019 (COVID-19) pandemic is spreading rapidly. Critically ill cases of COVID-19 can rapidly progress to acute respiratory distress syndrome and multiple organ failures. However, no effective drugs have been available till now, leading more than 300,000 deaths up 29 April 2020. Here, we present a critically case utilizing umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs).
 Case presentation: A 72-year-old man was admitted, with the...
ABSTRACT The exclusion of cirrhosis is important in chronic hepatitis B (CHB) patients with normal alanine aminotransferase (ALT). We aimed to optimise the performance aspartate platelet ratio index (APRI) and fibrosis score based on four factors (FIB‐4) exclude these patients. Five hundred eighty ALT who underwent liver biopsy were included study. divided into derivation external validation sets. A grid search method was used identify new cut‐offs a negative predictive value (NPV) > 95%...
Abstract Objective We aimed to investigate clinical features and management of 55 COVID-19 patients in Wuxi, especially severe COVID-19. Methods Epidemiological, demographic, clinical, laboratory, imaging, treatment, outcome data were collected. Follow-up lasted until April 6, 2020. Results All included 47 (85.5%) non-severe 8 (14.5%) patients. Common comorbidities hypertension diabetes. symptoms fever, cough sputum. Lymphopenia was a common laboratory finding, ground-glass opacity chest CT...
Objective Patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) are characterized by severe function impairment, coagulation disorder, and multiple organ impairment. The aim of this study was to explore the predictive value antithrombin Ⅲ activity prognosis HBV-ACLF patients. Methods A total 186 patients were included in analysis, baseline clinical data recorded analyze risk factors affecting 30-day survival outcome Bacterial infection, sepsis, hepatic...
Tuberculosis (TB) remains a leading cause of mortality among individuals coinfected with HIV, characterized by progressive pulmonary inflammation. Despite TB's hallmark being focal granulomatous lung lesions, our understanding the histopathological features and regulation inflammation in HIV & TB coinfection incomplete. In this study, we aimed to elucidate these through an immunohistochemistry analysis co-infected patients, revealing marked differences. Notably, granulomas exhibited...
Background: Cases of excessive neutrophil counts in the blood severe coronavirus disease (COVID-19) patients have drawn significant attention. Neutrophil infiltration was also noted on pathological findings from autopsy. It is urgent to clarify pathogenesis neutrophils leading pneumonia COVID-19. Methods: A retrospective analysis performed 55 COVID-19 classified as mild (n = 22), moderate 25), and 8) according Guidelines released by National Health Commission China. Trends relating leukocyte...
To evaluate the efficacy and safety of entecavir (ETV) in patients with advanced schistosomiasis hepatitis B virus (HBV) co-infection.Sixty-seven HBV co-infection were enrolled this study. The randomly divided into ETV treatment group (n=35) control (n=32). adopted routine supportive therapy for 52 weeks, those received at a dose 0.5mg once daily on basis weeks. Hepatic fibrosis markers (hyaluronic acid, type III procollagen, IV collagen, laminin, fibronectin), Ishak score, alanine...
The recurrence of positive SARS-CoV-2 nucleic acid test results in patients with COVID-19 is becoming more important and warrants attention.This study reports 2 cases, a child mild an adult female moderate COVID-19, who were discharged after three consecutive negative tests later readmitted to the hospital for positivity. By tracking patients' symptoms, serum antibodies, imaging manifestations readmission, we found that they showed trend gradual improvement recovery throughout treatment....
Abstract The molecular properties of the circulating causative agents hand, foot and mouth disease (HFMD) in Wuxi remain unclear, posing diagnostic prevention challenges. Additionally, several regions mainland China, EV71 immunisation drastically reduced related cases altered HFMD pathogen spectrum, while precise situation remained unknown. To address these issues, paediatric diagnosed clinic were enrolled anal swabs acquired spring 2019. 5′-UTR VP1 genes interpreted using RT-nPCR with...
Objective: To observe the short-term effect of sequentially combined multimodal artificial liver treatment (SCMALT) on HBV-related acute-on-chronic failure (HBV-ACLF). Methods: HBV-ACLF patients 155 cases undergoing were analyzed, and they sorted into SCMALT group conventional-modal (CALT) group. The clinical data all recorded serum levels interleukin-8 (IL-8), chemokine interferon-inducible protein-10 (IP-10), interleukin-6 (IL-6) detected. changes in 30-day survival rate, cytokine level,...
: Normal serum transaminases and immunoglobulin G (IgG) levels are surrogate markers for hepatic histologic disease activity in autoimmune hepatitis (AIH). This study aimed to evaluate liver inflammation patients with AIH normal alanine aminotransferase (ALT) IgG levels. Two hundred five who underwent biopsy four medical centers were included. Logistic regression analysis was used identify risk factors associated advanced inflammation. One thirty-one (63.9 %) had inflammation, 108 (52.7...
Functional cure for chronic hepatitis B (CHB) remains challenging due to the lack of direct intervention methods hepatic inflammation. Multi-omics research offers a promising approach understand inflammation mechanisms in CHB. A Bayesian linear model linked gene expression with clinical parameters, and population-specific analysis (PSEA) refined bulk into specific cell types across different phases. These models were integrated our key factors like inflammatory cells, immune activation, T...
Background: A critical issue is to identify COVID-19 patients early who develop severe pneumonia. Understanding the relationship of laboratory parameters and radiological features may improve diagnosis pneumonia.Methods: retrospective analysis was performed on 55 confirmed included mild, moderate, cases. The kinetic clinical characteristics these groups were compared. Blood CT values, estimated by chest scan, in 23 analyzed. Bayesian inference used quantify trend major parameters.Findings:...
Abstract The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 had resulted in a global pandemic. A comprehensive analysis of pediatric COVID-19 cases is essential to decipher the natural features children under risk this disease. In epidemic period, all infected with Wuxi, city stable medical system during outbreak China, were enrolled for data documenting their clinical, prognosis, follow-up, treatment and various tests results. Combing family cluster characteristics,...
Oral anti-viral agents nucleos(t)ide analogues (NAs) are widely used in treatment of chronic hepatitis B (CHB) since they well-tolerated most patients. But clinical relapse occurs a considerable part patients after the cessation NAs therapy. This paper reviews factors related to relapse, including time for drug withdrawal, cccDNA level, age, baseline alanine aminotransferase (ALT) and HBV DNA levels, type NAs, serum level HBsAg immune status patients. Key words: Hepatitis B,...
Objective To investigate the efficacy and safety of entecavir (ETV) in treatment patients with hepatitis B virus-associated glomerulonephritis (HBV-GN) different creatinine clearance rates (Ccr). Methods A total 108 HBV-GN Fifth People's Hospital Wuxi during July 2006 January 2012 were enrolled. According to Ccr levels, all divided into group A (≥80 mL/min, n=32), (50-<80 n=31), C (30-<50 n=25) D (<30 n=20). All received conventional therapy ETV for 52 weeks, dosages 0.5, 0.25 0.15...