A5085281958- Hepatitis C virus research
- Hepatitis B Virus Studies
- Cervical Cancer and HPV Research
- Parvovirus B19 Infection Studies
- Viral-associated cancers and disorders
- HIV Research and Treatment
- Viral gastroenteritis research and epidemiology
- Cytomegalovirus and herpesvirus research
- Genital Health and Disease
- Polyomavirus and related diseases
- Hepatitis Viruses Studies and Epidemiology
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Herpesvirus Infections and Treatments
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Dermatological and COVID-19 studies
- MicroRNA in disease regulation
- Full-Duplex Wireless Communications
- Antenna Design and Analysis
- Sex work and related issues
- Lymphoma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Viral Infections and Immunology Research
Iran University of Medical Sciences
2016-2025
San Diego Housing Federation
2021
Tehran University of Medical Sciences
2011-2013
Currently available anti-influenza drugs are often associated with limitations such as toxicity and the appearance of drug-resistant strains. Therefore, there is a pressing need for development novel, safe more efficient antiviral agents. In this study, we evaluated activity zinc oxide nanoparticles (ZnO-NPs) PEGylated against H1N1 influenza virus.The were characterized using inductively coupled plasma mass spectrometry, x-ray diffraction analysis, electron microscopy. MTT assay was applied...
We aimed to determine the possible inhibitory effects of zinc oxide nanoparticles (ZnO-NPs) and polyethylene glycol (PEG)-coated ZnO-NPs (ZnO-PEG-NPs) on herpes simplex virus type 1 (HSV-1).PEGylated were synthesized by mechanical method. Antiviral activity was assessed 50% tissue culture infectious dose (TCID50) real-time PCR assays. To confirm antiviral expression HSV-1 antigens, indirect immunofluorescence assay also conducted.200 μg/ml ZnO-PEG-NPs could result in 2.5 log10 TCID50...
Hepatitis C virus (HCV) has different genotypes throughout the world. Since determination of which antiviral treatment to be applied is related HCV genotypes, identification an individual's prior therapy critical.The purpose this study was investigate distribution in a large population Iranian infected patients.Eleven thousand, five hundred and sixty one patients with chronic infection referred hospitals Tehran University Medical Sciences Center-Clinical Department Baqiyatallah Research...
Background: Occult hepatitis C virus (HCV) infection is a new entity described by the presence of HCV-RNA in liver biopsy and/or peripheral blood mononuclear cell (PBMC) specimens, and undetectable levels or absence anti HCV antibodies plasma current laboratory methods. Objectives: To evaluate detection PBMC specimens transplant candidates with cryptogenic cirrhosis reverse transcriptase-nested polymerase chain reaction (RT-nested PCR). Patients Methods: From November 2007 to March 2013, 45...
Persistent infection with high-risk human papillomavirus (HPV) has been recognized as a major cause of cervical cancer. Distribution HPV genotypes may differ according to the geographic region and severity lesion. Determining genotypes' specific distribution is useful for surveillance control programs. However, little known about in Iranian women.The aim this study was determine women different grades lesions.From 2011 2013, total 436 convenience sampling strategy were included...
Human papillomavirus (HPV) is the most common viral sexually-transmitted infection. Despite HPV infection associated with several malignant disorders including penile and anal cancers, little known about epidemiology of in males, particularly developing countries.The aim this study was to determine prevalence its genotype distribution among Iranian males.Between March 2009 April 2014, a total number 483 referred Iran University Medical Sciences-affiliated sexually transmitted infections...
Despite decades of epidemiological investigation, little is known about the etiology central nervous system (CNS) tumors, and few well-established risk factors have been recognized. This study tested presence Merkel cell polyomavirus (MCPyV), only member Polyomaviridae family convincingly linked to human cancer, in diverse CNS malignancies. In total, 58 tumor biopsies were analyzed for MCPyV large T-antigen (LT-Ag) gene by quantitative real-time PCR. LT-Ag DNA load was determined as viral...
Interferons are able to exert an antiviral effect against hepatitis C virus (HCV) infection via induction of interferon-stimulated genes (ISGs). This study tested whether differential expression important ISG with properties, tripartite motif 22 (TRIM22), correlates a response Peg-IFNα-2a/RBV combination therapy in treatment-naive patients chronic C. A total 32 were enrolled this and received standard therapy. HCV viral load was measured during treatment, at the end 6 months later determine...
Determination of the Hepatitis C virus (HCV) genotype distributed in a particular area has an important role on public health throughout world.The aim this study was to determine frequency HCV genotypes Azerbaijani patients.From March 2010 until 2012, 235 patients with established chronic hepatitis C, referred Hospitals related Iran University Medical Sciences and Tehran Center, Clinical department Baqiyatallah Research Center for Gastroeneterology Liver Disease, were enrolled cross...
Chelidonium majus Linnaeus (L) has been used in a variety of practical applications medical sciences. Its antiviral activity against herpes simplex virus type-1 (HSV-1) was investigated cell culture. C. majus L. extract found to be non-toxic Vero cells (African green monkey kidney cells) up concentration 1000 mg/ml and inhibited the growth development HSV-1 dose-dependent manner cells. In order study possible mechanisms of C. extract, were treated with before, during after infection, viral...
Aim: The aim of this study was to assess the relationship between microRNAs and viral immunological markers in HIV-1 infection. Materials & methods: expression level miRNAs evaluated 60 patients 20 healthy controls using real-time PCR assays. Results: results showed that among all miRNAs, miR-29 miR-150 were significantly downregulated compared with controls, while miR-155 miR-223 upregulated (p < 0.001 for comparisons). Conclusion: mentioned seem influence clinical progression infection...
The etiology and molecular mechanisms involved in the development of breast cancer still remain poorly understood. Some epidemiological studies have shown an association between human papillomavirus (HPV) cancer. However, findings are controversial.Our study was aimed to investigate presence HPV DNA carcinomas Iranian women.In total, 72 samples formalin-fixed paraffin-embedded (FFPE) tissues collected December 2014 April 2016 were examined. detection performed by nested-PCR assay. Next,...