A5000662074- Plant Molecular Biology Research
- Plant Reproductive Biology
- Invertebrate Immune Response Mechanisms
- Cellular Mechanics and Interactions
- Neurobiology and Insect Physiology Research
- Insect symbiosis and bacterial influences
- Plant nutrient uptake and metabolism
- Legume Nitrogen Fixing Symbiosis
- Collagen: Extraction and Characterization
- Tissue Engineering and Regenerative Medicine
- Periodontal Regeneration and Treatments
- Genetics, Aging, and Longevity in Model Organisms
- Immune cells in cancer
- Cryospheric studies and observations
- Immune Cell Function and Interaction
- Polysaccharides and Plant Cell Walls
- Glaucoma and retinal disorders
- 3D Printing in Biomedical Research
- Signaling Pathways in Disease
- Hippo pathway signaling and YAP/TAZ
- Climate change and permafrost
- IL-33, ST2, and ILC Pathways
- Light effects on plants
- Elasticity and Material Modeling
- Autophagy in Disease and Therapy
Institute of Science and Technology Austria
2018-2023
Imtek (Russia)
2015
Bentham Science Publishers (United Arab Emirates)
2014
Institute of Experimental Cardiology
2014
Ministry of Health of the Russian Federation
2014
Bentham Science Publishers (China)
2014
Moscow State University
2011
Abstract Arabidopsis PIN2 protein directs transport of the phytohormone auxin from root tip into elongation zone. Variation in hormone transport, which depends on a delicate interplay between sorting to and polar plasma membrane domains, determines growth. By employing constitutively degraded version PIN2, we identify brassinolides as antagonists endocytosis. This response does not require de novo synthesis, but involves early events canonical brassinolide signaling. Brassinolide-controlled...
Cells migrate through crowded microenvironments within tissues during normal development, immune response, and cancer metastasis. Although migration pores tracks in the extracellular matrix (ECM) has been well studied, little is known about cellular traversal into confining cell-dense tissues. We find that embryonic tissue invasion by
The infiltration of immune cells into tissues underlies the establishment tissue-resident macrophages and responses to infections tumors. Yet mechanisms utilize negotiate tissue barriers in living organisms are not well understood, a role for cortical actin has been examined. Here, we find that invasion Drosophila macrophages, also known as plasmatocytes or hemocytes, utilizes enhanced F-actin levels stimulated by member fos proto oncogene transcription factor family (Dfos, Kayak). RNA...
Article23 March 2022Open Access Source DataTransparent process Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa-Porthos axis in Drosophila Shamsi Emtenani orcid.org/0000-0001-6981-6938 Institute of Science Technology Austria, Klosterneuburg, Austria Contribution: Conceptualization, Formal analysis, Investigation, Methodology, Writing - original draft Search for more papers this author Elliot T Martin Department Biological Sciences, RNA Institute,...
The intercellular transport of auxin is driven by PIN-formed (PIN) efflux carriers. PINs are localized at the plasma membrane (PM) and on constitutively recycling endomembrane vesicles. Therefore, can mediate either direct translocation across PM or pumping into secretory vesicles (SVs), leading to its release upon fusion with PM. Which these two mechanisms dominates a matter debate. Here, we addressed issue mathematical modeling approach. We demonstrate that efficiency depends SV size,...
Intercellular transport of auxin is driven by PIN-formed (PIN) proteins. PINs are localized at the plasma membrane (PM) and on constitutively recycling endomembrane vesicles. Therefore, can mediate either direct translocation across PM or pumping it into secretory vesicles (SVs), leading to its release upon fusion with PM. Which these two mechanisms dominates a matter debate. Here we addressed issue mathematical modeling approach. We demonstrate that efficiency depends SV size, half-life PM,...
ABSTRACT The infiltration of immune cells into tissues underlies the establishment tissue resident macrophages, and responses to infections tumors. Yet mechanisms utilize negotiate barriers in living organisms are not well understood, a role for cortical actin has been examined. Here we find that invasion Drosophila also known as plasmatocytes or hemocytes, utilizes enhanced F-actin levels stimulated by member fos proto oncogene transcription factor family (Dfos, Kayak). RNA sequencing...
Abstract Migration of cells through diverse tissues is essential for development, immune response and cancer metastasis 1–3 . To reach their destination, must overcome the resistance imposed by complex microenvironments, composed neighboring extracellular matrix (ECM) 4–6 While migration pores tracks in ECM has been well studied 4,5,7 , little known about cellular traversal into confining cell-dense tissues. Here combining quantitative live imaging with genetic optogenetic perturbations we...
Immune cells can move within our body, even between firmly attached cells. How do they overcome these impediments? Studying fruit fly embryos, we have discovered that immune take advantage of dividing Because intercellular attachments disassemble during division, it creates a weak spot in the dense tissue, through which migrate.