A5066439304- Advanced biosensing and bioanalysis techniques
- bioluminescence and chemiluminescence research
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Modular Robots and Swarm Intelligence
- Luminescence Properties of Advanced Materials
- Photochromic and Fluorescence Chemistry
- Luminescence and Fluorescent Materials
- 3D Printing in Biomedical Research
- CRISPR and Genetic Engineering
- Lipid Membrane Structure and Behavior
- Advanced Nanomaterials in Catalysis
- MicroRNA in disease regulation
- Photoreceptor and optogenetics research
- Pluripotent Stem Cells Research
- Neuroscience and Neural Engineering
Rutgers, The State University of New Jersey
2018-2024
Nondestructive neurotransmitter detection and real-time monitoring of stem cell differentiation are both great significance in the field neurodegenerative disease regenerative medicine. Although luminescent biosensing nanoprobes have been developed to address this need, they intrinsic limitations such as autofluorescence, scattering, phototoxicity. Upconversion nanoparticles (UCNPs) gained increasing attention for various biomedical applications due their high photostability, low...
In this study, we report the use of a multifunctional magnetic core–shell nanoparticle (MCNP), composed highly zinc-doped iron oxide (ZnFe2O4) core and biocompatible mesoporous silica (mSi) shell, for simultaneous delivery let-7a microRNA (miRNA) anticancer drugs (e.g., doxorubicin) to overcome chemoresistance in breast cancer. Owing ability repress DNA repair mechanisms BRCA1 BRCA2) downregulate drug efflux pumps ABCG2), could sensitize chemoresistant cancer cells (MDA-MB-231) subsequent...
Abstract The CRISPR‐Cas9 technology has the potential to revolutionize treatment of various diseases, including Rett syndrome, by enabling correction genes or mutations in human patient cells. However, several challenges need be addressed before its widespread clinical application. These include low delivery efficiencies target cells, actual efficiency genome‐editing process, and precision with which CRISPR‐Cas system operates. Herein, study presents a Magnetic Nanoparticle‐Assisted Genome...
In the present study, we fabricated magnetic oleosomes functionalized with recombinant proteins as a new carrier for oil-based lipophilic drugs cancer treatment. The bioengineered oleosome is composed of neutral lipids surrounded by phospholipid monolayer embedded oleosin fusion proteins. was genetically fused to nanobody green fluorescent protein (GFP). A consisting immunoglobulin-binding LG GFP used couple an antibody targeted delivery breast cells. lipid core loaded nanoparticles and...
Multifunctional nanoparticles that carry chemotherapeutic agents can be innovative anticancer therapeutic options owing to their tumor-targeting ability and high drug-loading capacity. However, the nonspecific release of toxic DNA-intercalating drugs from has significant side effects on healthy cells surrounding tumors. Herein, we report a tumor homing reactive oxygen species nanoparticle (THoR-NP) platform is highly effective selective for ablating malignant Sodium nitroprusside (SNP)...
Light-mediated remote control of stem cell fate, such as proliferation, differentiation, and migration, can bring a significant impact on biology regenerative medicine. Current UV/vis-mediated approaches are limited in terms nonspecific absorption, poor tissue penetration, phototoxicity. Upconversion nanoparticle (UCNP)-based near-infrared (NIR)-mediated systems have gained increasing attention for vast applications with minimal good penetration depth, phototoxicity from NIR excitations....
In article number 1806991, Ki-Bum Lee and co-workers describe NIR-based biosensing of neurotransmitters in stem-cell-derived neural interfaces using core–shell upconversion nanoparticles (UCNPs), which presents a unique tool for investigating the single-cell mechanisms associated with dopamine, or other neurotransmitters, their roles neurological processes.