A5101952594- Parkinson's Disease Mechanisms and Treatments
- Glycosylation and Glycoproteins Research
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Lysosomal Storage Disorders Research
- COVID-19 and Mental Health
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Systems and Public Health
- Mitochondrial Function and Pathology
- Posttraumatic Stress Disorder Research
- Evaluation Methods in Various Fields
- Educational Reforms and Innovations
- Medical Research and Treatments
- Neurological disorders and treatments
- Resilience and Mental Health
- Chronic Disease Management Strategies
- Health and Well-being Studies
- Dementia and Cognitive Impairment Research
- Nuclear Receptors and Signaling
- Aldose Reductase and Taurine
- Foot and Ankle Surgery
- Health, Environment, Cognitive Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Wildlife Conservation and Criminology Analyses
- Adenosine and Purinergic Signaling
Dalian Medical University
2014-2025
Southwest Medical University
2019-2025
Bengbu Medical College
2024
Qiqihar Medical University
2024
Beijing Tian Tan Hospital
2022
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022
Chongqing Medical University
2022
Second Affiliated Hospital of Xi'an Jiaotong University
2022
Northwest A&F University
2022
Karlstad University
2022
Abstract Background The incidence of early-onset colorectal cancer (EOCRC, diagnosed in patients under the age 50 years) has been increasing around world. Here, we aimed to systematically identify distinctive features EOCRC. Methods From 2020 2021, conducted a nationwide survey 19 hospitals, collecting data on advanced CRC patients’ demographics, clinical features, disease knowledge, medical experiences, expenditures, and health-related quality life (HRQOL). We compared these between EOCRC...
Achieving viral suppression through effective treatment adherence is critical for adolescents with HIV; however, the role of self-efficacy—an individual's confidence in their ability to consistently follow antiretroviral therapy (ART) regimens—remains under-explored among Chinese adolescents. This gap particularly concerning given United Nations' "95-95-95" targets end AIDS epidemic by 2030. The aim this study investigate self-efficacy levels Yi ethnic HIV a county Liangshan Prefecture, and...
BACKGROUND:The os trigonum is an accessory bone that not fully fused with the talus during secondary ossification, and one of risk factors posterior malleolus impact syndrome. The purpose this study was to classify guide diagnosis treatment related clinical diseases. MATERIAL AND METHODS:Ankle computed tomography (CT) scans 586 Chinese patients between October 2014 2018 were reviewed. CT images 1011 ankle joints reconstructed evaluate classification measurement anatomical parameters....
Abstract Plasma markers have been continuously advocated as pointers to estimate the long-term risk of cardiovascular disease in general population. We examined relationship between plasma high-sensitivity C-reactive protein (hs-CRP), homocysteine (Hcy), cardiac troponin T (hs-cTnT), N-terminal prohormone brain natriuretic peptide (NT-proBNP), 25-Hydroxyvitamin D (25OHD), glycosylated hemoglobin A1c (HbA1c), and serum uric acid (SUA) levels hypertension middle old aged A total 2624 Chinese...
Objective: To identify the prevalence of comorbid anxiety and depression (CAD) analyze relationship between CAD sociodemographic obstetric-related variables in pregnant postpartum Chinese women during COVID-19 pandemic. Methods: Participants were 2,237 (aged 19-47 years) who visited various medical institutions China February 28, 2020, April 26, 2020. They asked to complete an online survey assessing depression, obstetric characteristics, variables. The grouped into following categories...
The imbalanced allocation of medical resources leads to the occurrence cross-regional healthcare-seeking in China. Due low cure rate, advanced colorectal cancer (CRC) patients may seek healthcare for high-level facilities. Investigating status and its associated factors among CRC is important policymakers understand access health services improve quality oncology services.From March 2020 2021, a cross‑sectional, nation-wide, hospital-based, multi-center survey was conducted. Nineteen...
Objective This study aims to explore the influencing factors of depressive symptoms in middle-aged and older adult patients with hearing loss construct a nomogram risk prediction model. Methods A total 2,729 from community were selected as subjects. Single-factor multifactorial stepwise logistic regression analyses used screen factors. Based on these predictive factors, model was constructed. The model’s efficacy validated using area under receiver operating characteristic curve (AUC) 1,000...
Dietary factors and history of smoking remain elusive in the pathogenesis Parkinson's disease (PD).We investigated association environmental with PD a rural population China.Subjects were participants past nutritional intervention trial. Information on their characteristics was collected during baseline interview Control subjects randomly selected from same cohort frequency matched for sex, age residential area.Among 16,488 surveyed, we diagnosed 464 PD. Then, four sex- age-matched controls...
Aberrant glycosylation of proteins has major implications for human diseases.To determine whether protein contributes to the pathogenesis Parkinson's disease (PD), a mouse model PD was established by injection 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).Induction PD-like features verified assessing motor impairment and confirming reductions in biological markers, including dopamine, 5hydroxytryptamine tyrosine hydroxylase, as well aggregation α-synuclein.Altered detected using...
Vascular factors and mitochondria dysfunction contribute to the pathogenesis of Alzheimer's disease (AD). DL-3-n-butylphthalide (NBP) has an effect in protecting improving microcirculation.The aim was investigate donepezil combined NBP therapy patients with mild-moderate AD.It a prospective cohort study. 92 AD were classified into alone group (n = 43) or 49) for 48 weeks. All evaluated Disease Assessment Scale-Cognitive subscale (ADAS-cog), Clinician's Interview-Based Impression Change plus...
Abstract Background ADP/ATP translocase 1 (ANT1) is involved in the exchange of cytosolic ADP and mitochondrial ATP, its defection plays an important role pathogenesis. To reveal etiological implication ANT1 for Parkinson’s disease (PD), a neurodegenerative disorder, mouse model treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine neuroblastoma cell induced by 1-methyl-4-pehny1-pyridine were utilized this study. Results The tissue-specific abundance brains was accessed using analysis...
To explore the optimal cutoff score for initial detection of Alzheimer's Disease (AD) through Chinese version Mini-Mental State Examination (CMMSE) in rural areas China, we conducted a cross-sectional study within Linxian General Population Nutritional Follow-up study. 16,488 eligible cohort members participated survey and 881 completed CMMSE. Among participants, median age (Interquartile range) was 69.00 (10.00), 634 (71.92%) were female, 657 (74.57%) illiterate, 35 (3.97%) had 6 years...
To investigate the association between serum 25-hydroxyvitamin D (25-[OH]D) concentrations and metabolic syndrome (MetS) in middle-aged elderly Chinese population.
ABSTRACT Background Colorectal cancer (CRC) treatment and patient survival improved greatly. Consequently an increased incidence of non‐cancer‐related deaths is observed. This study analyzed the causes non‐cancer death for people suffering from CRC based on year diagnosis, follow‐up time, patient's age. Methods The data patients diagnosed with in years 2000–2016 were taken Surveillance, Epidemiology, End Results 18 database. Patients categorized according to: CRC, non‐CRC cancer, non‐cancer....
Colorectal cancer (CRC) is the 3rd most common malignancy globally, and its disease burden increasing rapidly in China. But CRC patients' knowledge awareness of have not yet been examined, which could facilitate identification targeted population from public for intervention.A nationwide multicenter cross-sectional survey was conducted 19 tertiary hospitals (10 9 general hospitals) March 2020 to 2021 During study period, all Stage III IV patients were invited complete a semi-structured that...
Background: Medical care workers experienced unprecedented levels of workload and pressure since the outbreak COVID-19 started from end 2019. Little is known about its exact impact on medical related factors in China.Methods: A cross-sectional survey was conducted among 863 7 provinces China using standard questionnaires measuring adverse psychological outcomes including Impact Event Scale-6 (IES-6), Depression, Anxiety Stress Scale(DASS)and psychosocial like perceived threat, social support...
Clinical practice guidelines are supposed to be evidence based and unbiased. High quality have the potential promote use of effective clinical services, minimize undesirable variation, reduce unnecessary services. Unfortunately, most produced thus far flawed untrustworthy. may still intrinsic limitation being too disease-focused rather than patient-focused, lack applicability validity when dealing with patients multiple comorbidities or diseases. When applicable, serve as a relative...
Patients with chronic liver disease (CLD) have extrahepatic manifestations and impaired health-related quality of life (HRQOL), hepatitis C virus (HCV) infection is a leading cause CLD, cirrhosis, hepatocellular carcinoma (HCC). This study aimed at assessing HRQOL in patients HCV the rural areas identifying factors associated impairment HRQOL. A cross-sectional was conducted county Liaoning Province northeast China. assessed using questionnaire (CLDQ) EuroQol-5 dimensions (EQ-5D). Data were...
Colorectal cancer (CRC) poses a significant public health burden worldwide. The investigation of the choice medical facility among CRC patients is helpful for understanding access to services and improving quality oncology optimize outcomes. However, there are limited studies on topic. objective this study was investigate its associated factors advanced patients.This cross-sectional multi-center included total 4,589 individuals with from 19 hospitals in 7 geographic regions China....