Valérie Freiche

ORCID: 0000-0003-2041-078X
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About
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Research Areas
  • Veterinary Oncology Research
  • Gastrointestinal Tumor Research and Treatment
  • Tracheal and airway disorders
  • Gastrointestinal disorders and treatments
  • Infectious Diseases and Mycology
  • Lymphoma Diagnosis and Treatment
  • Salivary Gland Tumors Diagnosis and Treatment
  • T-cell and B-cell Immunology
  • Esophageal and GI Pathology
  • Clinical Nutrition and Gastroenterology
  • Mycobacterium research and diagnosis
  • Intestinal and Peritoneal Adhesions
  • Intestinal Malrotation and Obstruction Disorders
  • Pancreatic and Hepatic Oncology Research
  • Diet and metabolism studies
  • Animal health and immunology
  • Veterinary Pharmacology and Anesthesia
  • Gallbladder and Bile Duct Disorders
  • Cardiovascular Conditions and Treatments
  • Healthcare Systems and Practices
  • T-cell and Retrovirus Studies
  • Pediatric Pain Management Techniques
  • Viral gastroenteritis research and epidemiology
  • Virus-based gene therapy research
  • Pediatric Hepatobiliary Diseases and Treatments

École Nationale Vétérinaire d'Alfort
2016-2025

Université Paris Cité
2018-2025

Inserm
2025

Institut des Maladies Génétiques Imagine
2019-2025

École Nationale Vétérinaire de Toulouse
2018

Centre Hospitalier Vétérinaire Frégis
2005-2018

Université Paris-Est Créteil
2015-2016

Digital Research Alliance of Canada
2013

To determine the prevalence of gastrointestinal tract lesions in brachycephalic dogs with upper respiratory disease.The and disorders 73 presented signs were evaluated. Clinical endoscopic histological anomalies digestive analysed.A very high problems was observed clinically, endoscopically histologically. Endoscopic present even without clinical signs. Furthermore, evaluation sometimes showed inflammatory not macroscopically visible at endoscopy. Statistical analysis a relationship between...

10.1111/j.1748-5827.2005.tb00320.x article EN Journal of Small Animal Practice 2005-06-01

After a first clinical study showing high prevalence of gastrointestinal tract diseases in brachycephalic dogs presented for upper respiratory syndrome, prospective was performed to determine the influence medical treatment disorders associated with syndrome surgery.The and 61 were evaluated. Together surgery tract, specific administered. A minimal follow-up six months required inclusion.Palatoplasty rhinoplasty most common surgical correction (88.5 per cent). The mortality rate...

10.1111/j.1748-5827.2006.00057.x article EN Journal of Small Animal Practice 2006-03-01

Lymphoplasmacytic enteritis (LPE) and low-grade intestinal T cell lymphoma (LGITL) are common diseases in older cats, but their diagnosis differentiation remain challenging.

10.1111/jvim.16690 article EN cc-by-nc Journal of Veterinary Internal Medicine 2023-05-01

Canine chronic enteropathies (CE) are a group of disorders defined by persistent or recurrent clinical signs gastrointestinal disease without primary neoplastic, metabolic, parasitic, other infectious cause. In this prospective, multicentre, uncontrolled, open-label study, commercial dry diet with protein source extensively hydrolysed poultry feather was assessed in the management dogs CE that had not responded to previous dietary and antibacterial therapies. Dogs moderate marked...

10.1186/s12917-025-04528-y article EN cc-by-nc-nd BMC Veterinary Research 2025-02-15

Background Acute pancreatitis (AP) is associated with a high death rate in dogs, but accurate predictors of early are still lacking. Objectives To develop scoring system for prediction short‐term case fatality dogs AP. Animals One hundred sixty‐nine AP including 138 the training cohort and 31 validation cohort. Methods Multicenter, retrospective study. Survival analysis was used to assess associations (within 30 days after admission). Independent were identified by stepwise selection method...

10.1111/jvim.15421 article EN cc-by-nc Journal of Veterinary Internal Medicine 2019-02-15

To evaluate fecal calprotectin concentrations in healthy dogs and with chronic diarrhea, to identify cutoff values for use differentiating diarrhea a canine enteropathy clinical activity index (CCECAI) < 12 from CCECAI ≥ 12, the association between histologic evidence of intestinal mucosal changes diarrhea.Fecal samples 96 adult (27 69 control dogs).Severity signs was evaluated on basis scoring system. Endoscopy performed all biopsy specimens were histologically. Fecal concentration...

10.2460/ajvr.74.5.706 article EN American Journal of Veterinary Research 2013-04-29

Abstract Background Differentiation of low‐grade intestinal T‐cell lymphoma (LGITL) from lymphoplasmacytic enteritis (LPE) in cats is a diagnostic challenge for pathologists. Objective Characterize histologic, immunohistochemical, and molecular features LGITL LPE. Animals Forty‐four client‐owned cats, 22 diagnosed with Methods Prospective, cohort study. Clinical suspicion or LPE was based on persistent gastrointestinal signs, unresponsive to empirical treatments. All underwent standardized...

10.1111/jvim.16231 article EN cc-by-nc-nd Journal of Veterinary Internal Medicine 2021-08-10

Two field trials, involving 66 cats (15 trial 1; 51 2) were conducted to assess the efficacy of a psyllium-enriched diet for management constipation in cats. After investigations and faecal evacuation (by enema if required), all fed on moderate fibre, psyllium-enriched, dry extruded diet. Additional therapy was either not used (trial 1), or initially allowed but subsequently withdrawn possible 2). The well tolerated, palatability excellent. Most cases improved after initial (at 2 months; 1:...

10.1016/j.jfms.2011.07.008 article EN other-oa Journal of Feline Medicine and Surgery 2011-09-23

Background Limited evidence exists in the literature regarding whether a specific mount is preferable to use for processing endoscopically obtained gastrointestinal biopsy specimens. Hypothesis/Objectives To compare 3 methods of handling specimens from collection laboratory and determine if any technique produced superior results. Animals Twenty‐three dogs cats presented signs. Methods Prospective study with signs veterinary teaching referral hospital which underwent upper endoscopy. Biopsy...

10.1111/jvim.14403 article EN cc-by-nc Journal of Veterinary Internal Medicine 2016-07-01

A 5-year-old castrated male domestic shorthair cat presented with a 3-month history of weight loss, chronic diarrhoea and vomiting. Examination revealed large proximal duodenal lesion eventually diagnosed as feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) associated fungal filaments. Histological examination was performed following endoscopic biopsy. Direct mycological culture the biopsies presence siphomycetous fungus, which further identified Rhizopus microsporus....

10.1177/20551169231165246 article EN cc-by-nc Journal of Feline Medicine and Surgery Open Reports 2023-01-01

Objectives This study aimed to describe the ultrasonographic, endoscopic and histological characteristics of caecum ileocaecocolic junction in cats suffering from chronic clinical signs compatible with caecocolic disease. Methods Cats presenting suggestive a disease were prospectively recruited. All underwent an ultrasonographic examination caecum, ileum, colon, ileocolic lymph nodes local mesenteric fat, addition comprehensive abdominal ultrasonography. was followed by colonoscopy...

10.1177/1098612x16663594 article EN Journal of Feline Medicine and Surgery 2016-09-10

Low-grade intestinal T-cell lymphoma (LGITL) is the most common neoplasm in cats. Differentiating LGITL from lymphoplasmacytic enteritis (LPE) challenging because clinical signs, laboratory results, diagnostic imaging findings, histology, immunohistochemistry, and clonality features may overlap.To evaluate possible discriminatory clinical, ultrasonographic to differentiate LPE.Twenty-two cats diagnosed with 22 LPE based upon lymphoid clonality.Prospective, cohort study. Cats presented signs...

10.1111/jvim.16272 article EN cc-by Journal of Veterinary Internal Medicine 2021-10-23

Many cats with gastrointestinal signs have coexisting abnormalities in the intestine, liver and pancreas. Investigations typically involve clinicopathological tests, diagnostic imaging biopsy, either at coeliotomy or by non-invasive means. While exploratory enables all organs to be sampled simultaneously, it is invasive might not necessary. The aim of current study was assess performance preliminary clinical information predicting histopathological presence alimentary tract cats.

10.1177/1098612x15573091 article EN Journal of Feline Medicine and Surgery 2015-02-26

Objectives The aim of the study was to describe ultrasonographic and endoscopic appearance characteristics caecum in asymptomatic cats, correlate these findings with histology. Methods Ex vivo histologic evaluations a fresh were initially performed. Then, 20 privately owned or originating from reproductive colony, recruited. All cats had an examination ileocaecocolic junction, where thickness caecal wall, ileocolic lymph nodes echogenicity local fat assessed. They all underwent colonoscopy...

10.1177/1098612x15602740 article EN Journal of Feline Medicine and Surgery 2015-08-28

Objectives Inflammatory rectal strictures in dogs and cats have been rarely reported. The aim of this study was to describe nine cases their treatment by digital bougienage. Methods Medical records referred for constipation, dyschezia or tenesmus diagnosed with an inflammatory stricture were obtained from the database two referral centres between 2007 2014 reviewed. Results Four five met inclusion criteria. purebred kittens. Three had a history diarrhoea bone ingestion. Digital examination...

10.1111/jsap.12638 article EN Journal of Small Animal Practice 2017-02-28

CASE DESCRIPTION A 10-year-old spayed female Rottweiler was referred for evaluation because of a 2-month history regurgitation and weight loss, despite no apparent change in appetite. The dog had received antiemetic antacid treatment, without improvement. CLINICAL FINDINGS Physical examination revealed low body condition score (2/5), but other findings were unremarkable. Diffuse, global esophageal dilatation noted on plain thoracic radiographs, normal motility confirmed through...

10.2460/javma.252.3.330 article EN Journal of the American Veterinary Medical Association 2018-01-18

A 16-year-old domestic shorthaired cat with chronic kidney disease was presented a subacute history of weakness and anorexia. Severe hypercalcaemia identified attributed to cervical mass, diagnosed as parathyroid carcinoma after surgery. Renal function, evaluated by plasma creatinine, initially worsened during but fully returned previously documented values two months post-operatively.

10.1080/01652176.2014.900876 article EN Veterinary Quarterly 2014-01-02

Abstract OBJECTIVE To compare clinical, endoscopic, and histopathologic features between dogs with chronic gastritis (CG) without lymphofollicular hyperplasia (LFH). ANIMALS 64 56 CG (cases) (controls) LFH, respectively. PROCEDURES The medical record database of a referral clinic was searched to identify that underwent endoscopic examination the upper portion gastrointestinal tract were subsequently determined have or LFH October 2006 February 2011. Signalment histologic findings compared...

10.2460/javma.256.8.906 article EN Journal of the American Veterinary Medical Association 2020-03-30
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