A5039041949- Cancer survivorship and care
- Cancer-related cognitive impairment studies
- Lung Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Brain Metastases and Treatment
- Frailty in Older Adults
- Neuroinflammation and Neurodegeneration Mechanisms
- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Glioma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Palliative Care and End-of-Life Issues
- Cancer Treatment and Pharmacology
- Phagocytosis and Immune Regulation
- Intensive Care Unit Cognitive Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Myasthenia Gravis and Thymoma
- Cancer, Lipids, and Metabolism
- Medical Imaging Techniques and Applications
- Tracheal and airway disorders
- Nutrition and Health in Aging
- Immune cells in cancer
- Global Cancer Incidence and Screening
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
University of Rochester Medical Center
2020-2024
John Radcliffe Hospital
2024
University of Oxford
2024
University of Rochester
2015-2023
Hobart and William Smith Colleges
2021-2022
University of Kentucky
2020
Oxford University Hospitals NHS Trust
2013-2019
Guy's Hospital
2010-2012
The King's College
2012
Harefield Hospital
2011
Alzheimer's disease is the leading cause of dementia worldwide. TAM receptor tyrosine kinases (Tyro3, Axl, MerTK) are known for their role in engagement phagocytosis and modulation inflammation, recent evidence suggests a complex relationship between Mer, microglial amyloid plaques AD. Gas6, primary CNS ligand, reduces neuroinflammation improves outcomes murine models disease. Therefore, we hypothesized that AAV-mediated overexpression Gas6 would alleviate plaque pathology, reduce...
Cancer-related cognitive decline (CRCD) is an important clinical problem, but limited research exists on assessment of function in patients with lymphoma.The overall objective this nationwide, prospective, observational study conducted the National Cancer Institute Community Clinical Oncology Research Program (NCORP) was to assess changes memory, attention, and executive lymphoma from pre- (A1) postchemotherapy (A2) 6 months (A3). Individuals without cancer served as noncancer controls,...
Abstract Background Aging-related deficits that eventually manifest as frailty may be associated with poor emotional health in older patients advanced cancer. This study aimed to examine the relationship between and this population. Methods was a secondary analysis of baseline data from nationwide cluster randomized trial. Patients were aged ≥70 years incurable stage III/IV solid tumors or lymphomas, had ≥1 geriatric assessment (GA) domain impairment, completed Geriatric Depression Scale,...
Abstract Background Inflammation may contribute to cognitive difficulties in patients with breast cancer. We tested 2 hypotheses: inflammation is elevated cancer vs noncancer control participants and associated worse attention processing speed over the course of chemotherapy. Methods Serum cytokines (interleukin [IL]–4, 6, 8, 10; tumor necrosis factor [TNF]–α) soluble receptors [sTNFRI, II]) were measured 519 females before after chemotherapy 338 without serving as participants. Attention by...
Cancer-related fatigue is a prevalent and debilitating condition that persists for years into survivorship. Studies evaluating both fish oil supplementation on associations between consumption have shown mixed effects; it unknown what factors contribute to these differential effects. Herein, we investigate whether the nutritional status of cancer survivors was associated with serum omega-3 concentration or change in omega-3s throughout study, then if any were fatigue. Breast 4-36 months...
The optimal treatment for Masaoka stage IVA thymoma remains controversial. Whilst extrapleural pneumonectomy (EPP) has been proposed, we sought to examine the results of our institutional preference induction chemotherapy, cytoreductive surgery and intraoperative hyperthermic pleural irrigation. We undertook a retrospective study patients undergoing following chemotherapy over three-year period at institution. Between February 2007 2010, 42 underwent thymoma. Six with intent perform Complete...
Neuroinflammation driven by the accumulation of amyloid β (Aβ) can lead to neurofibrillary tangle formation in Alzheimer's Disease (AD). To test hypothesis that an anti-inflammatory immunomodulatory agent might have beneficial effects on and tau pathology, as well microglial phenotype, we evaluated glatiramer acetate (GA), a multiple sclerosis drug thought bias type 2 helper T (Th2) cell responses alternatively activate myeloid cells. We administered weekly subcutaneous injections GA or PBS...
Microglia, the resident immune cells of central nervous system (CNS), play multiple roles in maintaining CNS homeostasis and mediating tissue repair, including proliferating response to brain injury disease. Cranial irradiation (CI), used for treatment tumors, has a long-lasting anti-proliferative effect on number cell types brain, oligodendrocyte progenitor neural cells; however, CI CNS-resident microglial proliferation is not well characterized. Using sterile cortical needle stab model...
e24095 Background: Over half of patients receiving neurotoxic taxane, platinum, or bortezomib chemotherapy experience CIPN—a dose-limiting toxicity involving numbness and pain in the extremities. There are limited biomarkers treatments for CIPN partly due to lack knowledge its pathophysiology. Here, we studied whether involves changes brain’s sensory processing circuitry inform novel brain-based CIPN. Methods: Eleven scheduled receive rated severity (CIPN-20) completed an fMRI scan before...
10559 Background: Lung cancer is the leading cause of death in U.S, accounting for about 25% all mortality. The U.S Preventive Services Task Force has recommended annual screening lung using low-dose computed tomography (LDCT) scanning individuals at higher risk (aged 55-80 years with a >30 pack-year smoking history). Early detection LDCT reduces specific mortality by 20%. Despite its efficacy, uptake among high-risk remains low ( < 18%). purpose this study was to identify factors...
12109 Background: Cancer-related fatigue is a common, debilitating condition that can persist for months or years after cancer treatment. Time-restricted eating has been shown to improve circadian rhythm and strengthen rest activity patterns, therefore could help reduce persistent fatigue. Herein, we evaluated the feasibility of recruiting survivors two-week, single-arm, time-restricted intervention with 10-h window, assessed safety intervention, monitored adherence, obtained initial...
We present a case with successful use of mixed silicone and saline implant expanders to achieve mediastinal repositioning facilitated by periprocedural bimodal assessment. A 63-year-old man large central tumour underwent right pneumonectomy. He developed stridor dyspnoea 3 months later. Clinical radiological findings were consistent postpneumonectomy syndrome (figure 1A, B).1 ,2 Mediastinal was undertaken through the …