A5016860576- Eosinophilic Esophagitis
- Eosinophilic Disorders and Syndromes
- IL-33, ST2, and ILC Pathways
- Inflammatory Bowel Disease
- Patient Dignity and Privacy
- Esophageal and GI Pathology
- Patient-Provider Communication in Healthcare
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Aldose Reductase and Taurine
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Hormonal Regulation and Hypertension
- Diversity and Career in Medicine
- Colorectal Cancer Screening and Detection
- Cancer Research and Treatments
- Medical Malpractice and Liability Issues
- Global Health Workforce Issues
- Cardiac tumors and thrombi
- Food Allergy and Anaphylaxis Research
- Diverticular Disease and Complications
- Medical Education and Admissions
- Gastroesophageal reflux and treatments
University of Utah
2022-2025
Massachusetts General Hospital
2019-2024
Dana-Farber Cancer Institute
2021-2024
Harvard University
2020-2023
Boston Children's Hospital
2022
University of Washington
2016-2020
National Institutes of Health
2012
Howard Hughes Medical Institute
2012
University of Miyazaki
2001
Kumamoto University
2000-2001
Abstract Coordinated cell interactions within the esophagus maintain homeostasis, and disruption can lead to eosinophilic esophagitis (EoE), a chronic inflammatory disease with poorly understood pathogenesis. We profile 421,312 individual cells from esophageal mucosa of 7 healthy 15 EoE participants, revealing 60 subsets functional alterations in states, compositions, that highlight previously unclear features EoE. Active displays enrichment ALOX15 + macrophages, PRDM16 dendritic expressing...
Abstract BMSCs are critical regulators of the hematopoietic response to inflammation through secretion IL-6. Inflammation alters hematopoiesis, often by decreasing erythropoiesis and enhancing myeloid output. The mechanisms behind these changes how BM stroma contributes this process active areas research. In study, we examine questions in setting murine Toxoplasma gondii infection. Our data reveal that infection early myeloerythroid differentiation, blocking erythroid development beyond Pre...
Environmental enteropathy (EE) is a subclinical condition of the small intestine that highly prevalent in low- and middle-income countries. It thought to be key contributing factor childhood malnutrition, growth stunting, diminished oral vaccine responses. Although EE has been shown by-product recurrent enteric infection, its full pathophysiology remains unclear. Here, we mapped cellular molecular correlates by performing high-throughput, single-cell RNA-sequencing on 33 intestinal biopsies...
Background Data on the incidence of Eosinophilic gastrointestinal disease (EGID) distal to esophagus are scarce. This study aimed examine non-eosinophilic esophagitis (EoE) EGID in Sweden, as well its three entities; eosinophilic gastritis (EoG), enteritis (EoN), and colitis (EoC).
Abstract Introduction There are limited data on the relationship between eosinophilic esophagitis (EoE) and asthma. We aimed to assess risk of asthma in EoE patients compared with matched controls siblings. Methods Through ESPRESSO study, a Swedish nationwide population‐based histopathology cohort, we identified diagnosed 1989 2017 ( n = 1146) up 5 age‐ sex‐matched 5022). Cox regression generated hazard ratios (HRs) for developing sibling controls. Results The median age at diagnosis was 42...
Objective Eosinophils are hallmarks in allergic type 2 inflammation and known to release cytotoxic granule proteins that contribute inflammation. develop the bone marrow from hematopoietic stem cells once mature, have a limited lifespan culture, making them difficult study ex vivo . IL-33 has increasingly been shown as key regulator of via signaling through its receptor, ST2. The present was conducted detail method eosinophil differentiation determine response IL-33. Methods CD34+ CD14+ were...
Abstract Background Earlier studies on the possible association between eosinophilic esophagitis (EoE) and inflammatory bowel disease (IBD) have been contradictory. Methods Patients with biopsy‐verified EoE diagnosed 1990 2017 in Sweden ( n = 1587) were age‐ sex‐matched up to five general population reference individuals 7808). was defined using pathology reports from all 28 centers (the ESPRESSO study). Multivariate Cox regression then estimated hazard ratios for future IBD. IBD based...
This JAMA Insights Clinical Update discusses the symptoms, diagnosis, and management of eosinophilic gastrointestinal diseases.
Cachexia is a systemic metabolic disorder characterized by loss of fat and muscle mass, which disproportionately impacts patients with gastrointestinal malignancies such as pancreatic cancer. While the immunologic shifts contributing to development other adipose tissue (AT) pathologies obesity have been well described, immune microenvironment has not studied in context cachexia.
Background & AimsCrohn's disease (CD) likely represents decreased immune tolerance to intestinal bacterial antigens. Most CD patients have high titers of antibodies commensal proteins, including the outer membrane porin C (OmpC) Escherichia coli.MethodsBy using major histocompatibility complex II tetramers, we identified an HLA-DRB1∗15:01-restricted peptide epitope OmpC recognized by CD4+ T cells in peripheral blood mononuclear from HLA-DRB1∗15:01+ healthy control (HC) and...
Summary Background Eosinophilic oesophagitis (EoE) is associated with elevated IgG4 in oesophageal tissue and serum. Previously, we showed brush‐collected secretions of EoE patients contained food antigen‐specific antibodies IgA IgG4. It unknown whether other food‐specific are present along the surface oesophagus EoE. Aim To identify immunoglobulins than mucosal Methods Concentrations total IgA, IgG1, IgG2, IgG3, IgG4, IgM IgE were measured from active ( n = 19) inactive 9), non‐EoE controls...
Despite its increasing prevalence, the economic impact of eosinophilic esophagitis (EoE) is understudied.
A preliminary report from the recent phase 3 trial of benralizumab, a monoclonal antibody that binds to interleukin-5 receptor alpha (IL5Rα), in patients with EoE revealed medication use led tissue eosinophil eradication but did not meet clinical endpoint symptom resolution. Here, we characterized clinical, endoscopic, histologic, and transcriptional changes active following benralizumab treatment. We retrospectively examined treated at University Utah (n = 11) reviewed reported symptoms,...
ABSTRACT Background Eosinophilic esophagitis (EoE) is a chronic, inflammatory disease of the esophagus. Chronic inflammation has been linked to cancer development. We aimed study potential association between EoE and later diagnosis. Methods In this nationwide population‐based cohort study, we identified 1580 individuals with diagnosed 1990–2017 through Sweden's 28 pathology departments. Up five general population reference were matched on age sex ( n = 7533). A Cox regression analysis...
INTRODUCTION: There are limited data on the familial risk of distal eosinophilic gastrointestinal diseases (EGIDs) in patients with esophagitis (EoE). We analyzed gastritis/gastroenteritis (EG/EGE) and colitis (EC) as forms EGIDs using International Disease Classification-9/10 codes subjects EoE their relatives. METHODS: The Utah Population Database is a resource that links genealogy information medical records Utah. identified probands first-degree (FDRs), second-degree (SDRs), third-degree...
Abstract Environmental enteropathy (EE) is a subclinical condition of the small intestine that highly prevalent in low- and middle-income countries. It thought to be key contributing factor childhood malnutrition, growth-stunting, diminished oral vaccine responses. While EE has been shown by-product recurrent enteric infection, its full pathophysiology remains unclear. Here, we mapped cellular molecular correlates severity by performing high-throughput single-cell RNA-sequencing on 33...
Abstract Background and Aims Eosinophilic esophagitis (EoE) is an increasingly common, largely food allergen‐driven disease characterized by dysphagia. Prior infections are known to associate with other loss of tolerance diseases such as autoimmunity. We aimed determine if antecedent infection was associated later EoE development. Methods performed a case‐control study all patients biopsy‐verified diagnosed between 2000 2017 in Sweden ( n = 1587) matched 5 general population controls 7660)....