A5081713913- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Biochemical and Molecular Research
- Cardiovascular Effects of Exercise
- Muscle metabolism and nutrition
- Glycosylation and Glycoproteins Research
- Muscle and Compartmental Disorders
- Exercise and Physiological Responses
- Mosquito-borne diseases and control
- Galectins and Cancer Biology
- RNA and protein synthesis mechanisms
- Virology and Viral Diseases
- Carbohydrate Chemistry and Synthesis
- Toxin Mechanisms and Immunotoxins
- Ubiquitin and proteasome pathways
- Immune responses and vaccinations
- Advanced Proteomics Techniques and Applications
- Nitric Oxide and Endothelin Effects
- Vector-borne infectious diseases
- Parasites and Host Interactions
- Science and Education Research
- Studies on Chitinases and Chitosanases
- Metabolomics and Mass Spectrometry Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Insect Pest Control Strategies
Universidade de São Paulo
2016-2024
Universidade Estadual de Londrina
2013
Trypanosoma cruzi, the etiologic agent of Chagas disease, cycles through different life stages characterized by defined molecular traits associated with proliferative or differentiation state. In particular, T. cruzi epimastigotes are replicative forms that colonize intestine Triatomine insect vector before entering stationary phase is crucial for into metacyclic trypomastigotes, which infective mammalian hosts. The transition from exponential to quiescent represents an important step...
Background Chagas disease also known as American trypanosomiasis is caused by the protozoan Trypanosoma cruzi. Over last 30 years, has expanded from a neglected parasitic infection of rural population to an urbanized chronic disease, becoming potentially emergent global health problem. T. cruzi strains were assigned seven genetic groups (TcI-TcVI and TcBat), named discrete typing units (DTUs), which represent set isolates that differ in virulence, pathogenicity immunological features....
Congenital Zika syndrome was first described due to increased incidence of congenital abnormalities associated with virus (ZIKV) infection. Since the eye develops as part embryo central nervous system (CNS) structure, it becomes a specialized compartment able display symptoms neurodegenerative diseases and has been proposed noninvasive approach early diagnosis neurological diseases. Ocular lesions result from defects that occurred during embryogenesis can become apparent in newborns exposed...
Abstract The etiological agent of Chagas disease, Trypanosoma cruzi , is a complex seven genetic subdivisions termed discrete typing units (DTUs), TcI-TcVI and Tcbat. relevance T. diversity to the variable clinical course virulence, pathogenicity, drug resistance, transmission cycles ecological distribution requires understanding parasite origin population structure. In this study, we introduce PhyloQuant approach infer evolutionary relationships between organisms based on differential mass...
Identifying specific diagnostic and prognostic biological markers of COVID-19 can improve disease surveillance therapeutic opportunities. Mass spectrometry combined with machine deep learning techniques has been used to identify pathways that could be targeted therapeutically. Moreover, circulating biomarkers have identified detect individuals infected SARS-CoV-2 at high risk hospitalization. In this review, we surveyed studies mass spectrometry-based omics (proteomics, lipdomics,...
Abstract Evolutionary relationships among parasites of the subfamily Leishmaniinae, which comprises pathogen agents leishmaniasis, were inferred based on differential protein expression profiles from mass spectrometry‐based quantitative data using PhyloQuant method. distances following identification and quantification peptide abundances Proteome Discoverer MaxQuant software estimated for 11 species six Leishmaniinae genera. Results clustered all dixenous genus Leishmania, subgenera L....
Exertional rhabdomyolysis (ER) is a frequently observed consequence following sustained strenuous exercise. The incidence of exercise-induced has risen in the healthy population recent decades, posing potential systemic, life-threatening complications like acute kidney injury (AKI). Early diagnosis requires prompt identification and management to prevent morbidity. This case report details presentation 24-year-old male military member from amphibious command specialization course, who...
Exertional rhabdomyolysis (ER) is a frequently observed consequence following sustained strenuous exercise. The incidence of exercise-induced has risen in the healthy population recent decades, posing potential systemic, life-threatening complications like acute kidney injury (AKI). Early diagnosis requires prompt identification and management to prevent morbidity. This case report details presentation 24-year-old male military member from amphibious command specialization course, who...
Abstract IMPORTANCE Ocular complications in infants with Congenital Zika Syndrome (CZS) have been reported. However, the molecular mechanisms underlying of eye dysfunctions are presently unknown. OBJECTIVE A method (termed Cellular Imprinting Proteomics, CImP) for identification and quantification ocular surface proteome using a minimally invasive membrane filter device is described. Moreover, The CImP was applied to profile alterations eyes exposed virus (ZIKV) infection during gestation....
Abstract A new method to probe the conformational changes of glycoproteins on a systems-wide scale, termed limited deglycosylation assay (LDA), is described. The measures differential rate N-glycans natively folded proteins by common peptide:N-glycosidase F (PNGase F) enzyme which in turn informs their spatial presentation and solvent exposure protein surface hence ultimately glycoprotein conformation. LDA involves 1) protein-level N-deglycosylation under native conditions, 2) trypsin...
Abstract Evolutionary relationships among parasites of the subfamily Leishmaniinae, which comprises pathogen agents leishmaniasis, were inferred based on differential protein expression profiles from mass spectrometry-based quantitative data using PhyloQuant method. distances following identification and quantification peptide abundances Proteome Discoverer (PD) MaxQuant (MQ) softwares estimated for 11 species 6 Leishmaniinae genera. Results clustered all dixenous genus Leishmania ,...
ABSTRACT Leishmania parasites cause a spectrum of diseases termed leishmaniasis, which manifests in two main clinical forms, cutaneous and visceral leishmaniasis. promastigotes transit from proliferative exponential to quiescent stationary phases inside the insect vector, relevant step that recapitulates early molecular events metacyclogenesis. During blood meal mammalian hosts, released interact initially with skin, an event marked by temperature changes. Deep knowledge on activated during...
Abstract The etiological agent of Chagas disease, Trypanosoma cruzi , is subdivided into seven genetic subdivisions termed discrete typing units (DTUs), TcI-TcVI and Tcbat. relevance T. diversity to the variable clinical course virulence, pathogenicity, drug resistance, transmission cycles ecological distribution justifies concerted efforts towards understanding population structure strains. In this study, we introduce a novel approach ‘ phyloquant ’ infer evolutionary relationships...
Abstract Exertional rhabdomyolysis (ERM), a condition often associated with strenuous exercise, common practice in the military activities, can be defined as process of injury and rupture muscle cell membranes, leakage its components into blood stream. Creatine kinase (CK) has been extensively used for ERM diagnosis, albeit several studies reported discrepancy between CK levels clinical signs or symptoms. In this study, we analyzed biochemical profile blood, urinary proteome ten marine...