A5032900705- Phonetics and Phonology Research
- Linguistic Variation and Morphology
- Syntax, Semantics, Linguistic Variation
- Speech Recognition and Synthesis
- Speech and Audio Processing
- Fungal and yeast genetics research
- Microbial Metabolic Engineering and Bioproduction
- Glycosylation and Glycoproteins Research
- Microbial Natural Products and Biosynthesis
- Speech and dialogue systems
- Platelet Disorders and Treatments
- Natural Language Processing Techniques
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Atherosclerosis and Cardiovascular Diseases
- Lipid metabolism and disorders
- Multiple Myeloma Research and Treatments
- T-cell and Retrovirus Studies
- Plant Pathogens and Fungal Diseases
- Second Language Acquisition and Learning
- Biofuel production and bioconversion
- Categorization, perception, and language
- Viral-associated cancers and disorders
- Genomics and Phylogenetic Studies
- EFL/ESL Teaching and Learning
Hiroshima University
2017-2024
National Institute of Advanced Industrial Science and Technology
2007-2024
Hyogo Prefectural Amagasaki General Medical Center
2018-2021
Osaka University
2016-2021
University of British Columbia
2004-2017
Kobe University
2016
Futaba (Japan)
2008-2009
Shionogi (Japan)
1995-2009
Aoyama Gakuin University
2002
Many bioactive natural products are produced as "secondary metabolites" by plants, bacteria, and fungi. During the middle of 20th century, several secondary metabolites from fungi revolutionized pharmaceutical industry, for example, penicillin, lovastatin, cyclosporine. They generally biosynthesized enzymes encoded clusters coordinately regulated genes, motif-based methods have been developed to detect metabolite biosynthetic (SMB) gene using sequence information typical SMB core genes such...
The epidermal growth factor (EGF) and EGF receptor (EGFR) families play important roles in the hyperplastic of several tissues as well tumor growth. Since synovial hyperplasia rheumatoid arthritis (RA) resembles a tumor, involvement EGF/EGFR RA pathology has been implied. Although reports have suggested that ErbB2 is most member EGFR family for synovitis RA, it remains unclear which members are involved. To clarify EGF-like factors involved we investigated expression levels seven major...
Aspergillus oryzae has been utilized for over 1000 years in Japan the production of various traditional foods, and a large number A. strains have isolated and/or selected effective fermentation food ingredients. Characteristics genetic alterations among used are particular interest studies oryzae. Here, we sequenced whole genome an industrial fungal isolate, RIB326, by using next-generation sequencing system compared data with those RIB40, wild-type strain 2005. The aim this study was to...
Thrombocytopenia is a common problem in the management of patients with cancer and other conditions that affect hematopoietic cells. In previous clinical trials, polyethylene-glycol-conjugated recombinant human megakaryocyte growth development factor increased platelet counts idiopathic thrombocytopenic purpura solid tumors undergoing chemotherapy. However, antibodies to develop healthy volunteers chemotherapy cross-react endogenous thrombopoietin. As result, was discontinued 1998. The aim...
Umbelopsis isabellina is a fungus in the subdivision Mucoromycotina, many members of which have been shown to be oleaginous and become important organisms for producing oil because their high level intracellular lipid accumulation from various feedstocks. The genome sequence U. NBRC 7884 was determined annotated, this information might provide insights into properties fungus.
In Taiwan Mandarin, retroflex [ʂ] is allegedly merging with dental [s], reducing the traditional three-way contrast between sibilant fricatives (i.e., [s]–retroflex [ʂ]–alveopalatal [ɕ]) to a two-way contrast. Most of literature on observed focuses acoustic properties and perceptual identification sibilants, whereas much less attention has been drawn articulatory evidence accounting for aforementioned merging. The current study employed ultrasound imaging techniques uncover tongue postures...
Abstract During the pandemic, digital communication became paramount. Due to discrepancy between placement of camera and screen in typical smartphones, tablets laptops, mutual eye contact cannot be made standard video communication. Although positive effect traditional has been well-documented, its role virtual contexts remains less explored. In this study, we conducted experiments gauge impact gaze direction during a simulated online job interview. Twelve university students were recruited...
Abstract Aspergillus oryzae has been used in Japanese fermentation industries for more than a thousand years. The species produces large amounts of various hydrolytic enzymes and successfully applied to modern biotechnology. size the A. genome (37.5 Mb) is very close that flavus niger, 20–30% larger either nidulans or fumigatus. have exactly same number aspartic proteinase genes, which each orthologous pair shares highly conserved amino acid sequences. Synteny analysis with fumigatus showed...
The availability of a silkworm larva infection model to evaluate the therapeutic effectiveness antibiotics was examined. 50% effective doses (ED50) D-cycloserine against Staphylococcus aureus ddlA mutant-mediated killing larvae were remarkably lower than those parental strain-mediated larvae. Changes in MICs and ED50 other negligible, suggesting that these alterations are d-cycloserine selective. Therefore, this is useful for selecting desired compounds based on their during antibiotic development.
One usage of medical ultrasound imaging is to visualize and characterize human tongue shape motion during a real-time speech study healthy or impaired production. Due the low-contrast characteristic noisy nature images, it might require expertise for non-expert users recognize gestures in applications such as visual training second language. Moreover, quantitative analysis needs dorsum contour be extracted, tracked, visualized. Manual extraction cumbersome, subjective, error-prone task....
Secondary expansion and/or evolution of aggressive subclones are associated with the disease progression and resistance to chemotherapy in neuroblastoma, it is important track clonal changes during treatment period. Cell-free (cf) DNA analysis, namely liquid biopsy, can detect genomic change tumor cells without surgical procedures. In this report, we showed that serial polymerase chain reaction–based cf neuroblastoma proto-oncogene quantification sensitive enough evaluate cellular...
We have identified a series of novel non-peptide compounds that activate the thrombopoietin-dependent cell line Ba/F3-huMPL. The stimulated proliferation Ba/F3-huMPL in absence other growth factors, but did not promote thrombopoietin-independent parent Ba/F3. thrombopoietin-mimetic elicited signal-transduction responses comparable with recombinant human thrombopoietin, such as tyrosine phosphorylation thrombopoietin receptor, JAK (Janus kinase) 2, Tyk2 (tyrosine kinase 2), STAT (signal...
Abstract Biological and medical importance of the single nucleotide polymorphism (SNP) has led to development a wide variety methods for SNP typing. Aiming establishing highly reliable fully automated typing, we have developed adapter ligation method in combination with paramagnetic beads handling technology, Magtration®. The utilizes sequence specific between fluorescently labeled sample DNAs at cohesive end produced by type IIS restriction enzyme. Evaluation using human genomic DNA showed...