A5019172845- Work-Family Balance Challenges
- Intergenerational Family Dynamics and Caregiving
- Social and Demographic Issues in Germany
- Ion Channels and Receptors
- Sociology and Education Studies
- Platelet Disorders and Treatments
- Social Policy and Reform Studies
- Family Dynamics and Relationships
- Family Support in Illness
- Circadian rhythm and melatonin
- Cell Adhesion Molecules Research
- Postharvest Quality and Shelf Life Management
- Phytochemicals and Antioxidant Activities
- Socioeconomic and Demographic Analysis
- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Youth Education and Societal Dynamics
- Psychoanalysis and Social Critique
- Gender, Labor, and Family Dynamics
- Psychology, Coaching, and Therapy
- Ion channel regulation and function
- Sleep and Wakefulness Research
- Protein Kinase Regulation and GTPase Signaling
- Signaling Pathways in Disease
- Complement system in diseases
University of Vienna
2014-2024
Institute for Interdisciplinary Studies of Austrian Universities
2022-2024
Theodore Roosevelt High School
2024
University Hospital Heidelberg
2017
Heidelberg University
2017
University of Tübingen
2011-2016
Martin Luther University Halle-Wittenberg
2014
Maastricht University
2013
Institute of Molecular Biology
2013
University of Duisburg-Essen
2013
Over the past two decades, scholars have investigated a multitude of different aspects motherhood. This article provides scoping review research published from 2001 to 2021, covering 115 Social Science Citation Index-referenced papers WEIRD countries, with aim reconstructing social norms around motherhood and mothers' responses them. The analysis is theoretically based on normological praxeological concepts. findings reveal five contemporary that reflect both stability increasing...
The recently discovered chemokine CXC motif ligand 16 (CXCL16) is highly expressed in atherosclerotic lesions and a potential pathogenic mediator coronary artery disease.The aim of this study was to test the role CXCL16 on platelet activation vascular adhesion, as well underlying mechanism signaling pathway.Reverse-transcriptase polymerase chain reaction, Western blotting, confocal microscopy, flow cytometry revealed that CXCL16-specific receptor, receptor 6, platelets. According stimulation...
Multiple perspective interviews (MPIs) involve interviewing members of a social group separately and triangulating their accounts during analysis to gain insights into the functioning such groups (e.g. families). So far, there has been little engagement with specific challenges MPI research analysis, particularly dissonant data. To illustrate importance this aspect, we draw on triangulation metaphor related epistemological ontological perspectives, which determine analytic choices thus yield...
The serum and glucocorticoid-inducible kinase SGK1 increases the activity of Orai1, pore forming unit store-operated Ca(2+) entry, thus influences Ca(2+)-dependent cellular functions such as migration. further regulates transcription factor nuclear κB (NF-κB). This study explored whether Orai1 and/or STIM1, Orai1-activating sensor. STIM1 transcript levels were decreased in mast cells from knock-out mice increased HEK293 transfected with active (S422D)SGK1 but not inactive (K127N)SGK1 or...
Cyclophilin A (CyPA) is secreted under inflammatory conditions by various cell types. Whereas the important role of intracellular CyPA for platelet function has been reported, effect extracellular on not investigated yet.Inhibition through a novel specific inhibitor MM284 reduced thrombus after ferric chloride-induced injury in vivo. In vitro enhanced formation even CyPA(-/-) platelets. Treatment isolated platelets with recombinant resulted degranulation time- and dose-dependent manner....
Chorea-acanthocytosis is an inevitably lethal genetic disease characterized by a progressive hyperkinetic movement disorder and cognitive behavioral abnormalities as well acanthocytosis. The caused loss-of-function mutations of the gene encoding vacuolar protein sorting-associated 13A (VPS13A) or chorein, with unknown function expressed in various cell types. How chorein deficiency leads to pathophysiology chorea-acanthocytosis remains enigmatic. Here we show decreased...
Collecting multiple perspectives data (e.g. from related individuals) in a qualitative longitudinal design can provide rich understanding of the dynamics at play complex relational systems, and different perceptions people involved. However, such approaches are inherently challenging due to complexity volume So far, little attention has been paid methodological challenges analysis research. This paper contributes development systematized process for interviews (MPQLI). We present framework...
Platelet activation is essential for primary hemostasis and acute thrombotic vascular occlusions. On activation, platelets release their prothrombotic granules expose phosphatidylserine, thus fostering thrombin generation thrombus formation. In other cell types, both degranulation phosphatidylserine exposure are modified by sphingomyelinase-dependent formation of ceramide. The present study explored whether acid sphingomyelinase participates in the regulation platelet secretion, exposure,...
Chorea-acanthocytosis (ChAc), a lethal disease caused by defective chorein, is characterized neurodegeneration and erythrocyte acanthocytosis. The functional significance of chorein in other cell types remained ill-defined. present study revealed expression blood platelets. As compared to platelets from healthy volunteers, patients with ChAc displayed 47% increased globular/filamentous actin ratio, indicating depolymerization. Moreover, phosphoinositide-3-kinase subunit p85 phosphorylation,...
As some scholars have argued for a distinct conceptualisation of breadwinning and understanding as form care, this study addresses parents' constructions its connections to care. It is based on an in-depth interpretive analysis multiple-perspective, qualitative longitudinal interviews with 22 Austrian mothers fathers from three points in time during their transition parenthood. The revealed four different types concepts by considering the jointly constructed meaning mothers' fathers' paid...
Zusammenfassung In diesem Beitrag fragen wir, welche Bedeutung Selbstsorge für Mütter in kollektiven Diskursen über gute Mutterschaft hat und Formen der Zusammenhang diskutiert werden. Infolge neoliberaler Tendenzen wird eine strukturelle Sorglosigkeit deutlich, es kommt zu Krisen Arbeits- Sorgearrangements. Gleichzeitig als Aufgabe etabliert, ohne einen adäquaten Rahmen dafür schaffen. Diese betrifft auch Mütter, die jedoch ebenso hauptverantwortlich Fürsorge betrachtet mit Anforderungen...
Abstract The RNA-binding protein CHLAMY1 from the green alga Chlamydomonas reinhardtii consists of two subunits. One (named C1) contains three lysine homology motifs and other C3) has RNA recognition motifs. binds specifically to uridine-guanine-repeat sequences its circadian-binding activity is controlled at posttranslational level, presumably by time-dependent formation complexes consisting C1 C3 or alone. Here we have characterized role subunits within circadian system measurements a...
Abstract Tumor growth is fostered by inhibition of cell death, which involves the receptiveness tumor to factors and hormones. We have recently shown that testosterone exerts proapoptotic effects in prostate colon cancer cells through a membrane-initiated mechanism. In addition, we reported dehydroepiandrosterone (DHEA) can control fate, activating nerve factor (NGF) receptors, namely tropomyosin-related kinase (Trk)A p75 neurotrophin receptor, primary neurons PC12 tumoral cells. NGF was...
Recent observations pointed to the ability of platelets migrate and thus invade inflamed vascular wall. Platelet migration could be stimulated by stromal cell-derived factor-1 (SDF-1), an effect dependent on phosphatidylinositide-3-kinase (PI3K) paralleled activation phosphorylation Wiskott-Aldrich syndrome protein (WASP). Migration is inhibited vinculin, which similarly regulated phosphorylation. PI3K-sensitive kinases include serum- glucocorticoid-inducible kinase 1 (SGK1). The present...
ABSTRACT The RNA-binding protein CHLAMY 1 from Chlamydomonas reinhardtii binds specifically to UG (≥7) repeat sequences situated in the 3′ untranslated regions of several mRNAs. Its binding activity is controlled by circadian clock. biochemical purification and characterization revealed a novel type protein. It includes two different subunits (named C1 C3), whose interaction appears necessary for RNA binding. One them (C3) belongs proteins CELF (CUG-BP-ETR-3-like factors) family thus bears...
The serum- and glucocorticoid-dependent kinases 1-3 (SGK1-3) are downstream effectors of phosphatidylinositol 3-kinases, implicated in various cell responses including colon cancer tumorigenesis mice. Here, we investigated the role SGK1 regulation motility. Using Caco-2 tumor HEK293 embryonic kidney cells, report that transfection with constitutively active mutant (SGK1-SD) significantly enhanced cell-adhesion protein vinculin was effectively dephosphorylated SGK1-SD-transfected cells....
Background/Aims: Side effects of vancomycin, a widely used antibiotic, include thrombocytopenia. The vancomycin-induced thrombocytopenia has been attributed to immune reactions. At least in theory, could result part from the triggering apoptosis, which results cell shrinkage and membrane scrambling with subsequent phosphatidylserine exposure at surface. be initiated by signaling involving increase cytosolic Ca2+ activity, ceramide formation, mitochondrial depolarization and/or caspase...
Pro-inflammatory cytokines like interleukin-1 beta (IL-1) are major players in the interaction between immune system and central nervous system. Various animal studies report a sleep-promoting effect of IL-1 leading to enhanced slow wave sleep (SWS). Moreover, this cytokine was shown affect hippocampus-dependent memory. However, role human memory is not yet understood. We administered synthetic receptor antagonist anakinra (IL-1ra) healthy humans (100mg, subcutaneously, before sleep; n=16)...
Platelets are activated by increased cytosolic Ca2+ concentration ([Ca2+]i) following store-operated calcium entry (SOCE) accomplished calcium-release-activated (CRAC) channel moiety Orai1 and its regulator STIM1. In other cells, transport is regulated 1,25(OH)2 vitamin D3 [1,25(OH)2D3]. 1,25(OH)2D3 formation inhibited klotho excessive in klotho-deficient mice (kl/kl). The present study explored the effect of deficiency on platelet signaling activation. megakaryocytes isolated from WT...
Men and masculinity are considered a key factor in changing gender inequality at the transition to parenthood. Prior research on gendered division of parental leave concentrated fathers' perspectives. This paper includes perspectives fathers mothers who make use different ways asks how is jointly constructed, these constructions linked leave, if they oriented towards hegemonic masculinity. The analysis based 44 qualitative interviews with 11 Austrian couples before after birth when decisions...
Abstract Thymoquinone (TQ) is a nutrient with anticarcinogenic activity that stimulates suicidal death of tumor cells. Moreover, TQ triggers erythrocytes or eryptosis, an effect at least partially due to increase in cytosolic Ca 2+ and ceramide formation. The present experiments explored whether influences apoptosis blood platelets. Cell membrane scrambling was determined utilizing Annexin V binding phosphatidylserine exposing platelets, Fluo 3‐AM fluorescence, caspase immunofluorescence...