A5047315432- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Adolescent and Pediatric Healthcare
- Family Support in Illness
- Reproductive Biology and Fertility
- Reproductive Health and Technologies
- Hematopoietic Stem Cell Transplantation
- Neuroblastoma Research and Treatments
- Cancer Risks and Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Neurogenetic and Muscular Disorders Research
- Medication Adherence and Compliance
- Chronic Lymphocytic Leukemia Research
- Glycogen Storage Diseases and Myoclonus
- Sarcoma Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Vascular Tumors and Angiosarcomas
- Cancer-related cognitive impairment studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Chronic Myeloid Leukemia Treatments
- Ethics in Clinical Research
- Autoimmune Neurological Disorders and Treatments
- Economic and Financial Impacts of Cancer
- Lysosomal Storage Disorders Research
- Safe Handling of Antineoplastic Drugs
Seattle Children's Hospital
2016-2025
University of Washington
2016-2025
Center for Cancer and Blood Disorders
2016-2025
Fred Hutch Cancer Center
2016-2024
University of Minnesota System
2022
University of California, Davis
2021
Seattle University
2017
Cancer Research Center
2017
University of Minnesota Children's Hospital
2015-2016
University of Minnesota
2013-2014
In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup unique epidemiology, clinical care needs, societal impact. Comprehensive estimates in (aged 15-39 years) lacking. To address this gap, we analysed results from Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2019, focus on outcome disability-adjusted life-years (DALYs), to inform control measures adults.
Background The impact of cancer and its treatment on employment financial burden in adolescents/young adults (AYAs) is not fully known. Methods Eligibility for this cross‐sectional study AYA survivors included the diagnosis a malignancy between ages 18 39 years survey completion within 1 to 5 from ≥1 year after therapy completion. Participants were selected randomly tumor registries 7 participating sites completed an online patient‐reported outcomes assess concerns. Treatment data abstracted...
ABSTRACT Background Adolescents and young adults (AYA) with cancer experience long‐term consequences into survivorship that impact quality of life, including mental health symptoms, substance use, persistent pain. Given the elevated rates pain, AYA survivors are at increased risk for opioid pain medication (OPM) exposure, increasing opioid‐related negative consequences, particularly those symptoms. Minimal research has documented a considerable proportion AYAs receive OPM continues...
ABSTRACT Adolescents and young adults (AYAs) with cancer face unique demands, which result in barriers to psychosocial/behavioral trial retention. Theory‐informed patient‐engaged strategies have the potential increase The purpose of this manuscript is illustrate how partner AYAs leverage Theoretical Domains Framework identify retention behavior change techniques (BCTs) targeting these create strategies. Exemplar developed using approach implemented our an adherence‐promotion intervention are...
Abstract Objective Our study objectives were to evaluate the relationship between Thyroid Imaging Reporting and Data System (TI‐RADS) Bethesda classification compare both TI‐RADS for diagnosis of papillary thyroid carcinoma (PTC) within pediatric population. Study Design Retrospective case series. Setting Academic hospital. Methods A 13‐year retrospective review was performed all patients undergoing fine needle aspiration (FNA) ultrasound at our institution. Demographics, scoring, FNA...
Background: Dysostosis multiplex contributes substantially to morbidity in patients with Hurler syndrome (mucopolysaccharidosis type I phenotype [MPS I-H]), even after successful hematopoietic stem cell transplantation (HSCT). One of the hallmarks dysostosis MPS I-H is hip dysplasia, which often requires surgical intervention. We sought describe detail course dysplasia this group patients, as assessed by radiographic analysis, and identify potential outcome predictors. Methods: Longitudinal...
Adult survivors of acute leukemia in childhood have a higher-than-expected frequency obesity and are at increased risk for metabolic syndrome early mortality from cardiovascular disease (CVD). Adipose tissue has been recognized as an endocrine paracrine organ that secretes various adipokines involved regulation inflammatory processes. In this study, we examined factors (IL-6 TNF-α) (adiponectin, leptin), addition to body composition adiposity, cancer who underwent hematopoietic cell...
Adherence promotion is a critical component of adolescent and young adult (AYA) cancer care, but predictors nonadherence that could be targeted in intervention efforts remain largely unknown. The purpose this multi-site longitudinal observational study was to examine the relationship between barriers medication adherence among AYAs with cancer.Sixty-five (ages 15-24 years; mean age = 18.97 years, SD 2.51; Mmean time since diagnosis 1.42 1.95) newly diagnosed or relapsed completed self-report...
Purpose: The majority of adolescent and young adult (AYA) cancer survivors do not receive recommended health care surveillance after therapy. We used cross-sectional survey data to evaluate the impact income, education, marital status, insurance on adherence among AYA survivors. Methods: Eligible were 18–39 years at diagnosis with invasive malignancy, 1–5 from therapy completion. Online surveys assessed sociodemographic factors self-report completion services. Diagnosis treatment abstracted...
Opsoclonus-myoclonus syndrome (OMS) may be associated with ANNA-1 (anti-Hu) autoantibodies. The standard treatment IVIG, steroids, and anti-CD20 monoclonal antibody fail, optimal therapy is unknown. A patient developed OMS high-titer following recovery from neuroblastoma. She failed had only transient response to rituximab. Treatment the humanized ofatumumab combined methotrexate resulted in neurologic improvement decrease of ANNA-1. This suggests that should further considered patients,...
Purpose: Despite health implications, sexual activity and substance use among adolescents young adults (AYAs) receiving cancer treatment are understudied. Methods: AYAs 12-25 years of age participated in a randomized controlled trial testing the efficacy resilience intervention. They were fluent English either diagnosed with new (NC) or advanced (AC). At baseline 6 months, participants self-reported use. We describe percentage who endorsed each behavior count total behaviors by respondent....
TPS10078 Background: Targetable kinase fusions and mutations are common in pediatric young adult patients with papillary thyroid cancer (TC) associated metastatic disease lack of response to radioactive iodine therapy (RAI). While survival outcomes excellent, less than 20% children TC achieve a complete standard treatment surgery Thus, repeated RAI is common, increasing the risk pulmonary fibrosis secondary malignancies. Targeted inhibitors highly effective at shrinking oncogene-driven TC....