A5028228845- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Neurogenesis and neuroplasticity mechanisms
- Autism Spectrum Disorder Research
- Memory and Neural Mechanisms
- Visual perception and processing mechanisms
- Genetics and Neurodevelopmental Disorders
- Photoreceptor and optogenetics research
- Neuroendocrine regulation and behavior
- Primate Behavior and Ecology
- Receptor Mechanisms and Signaling
- Face Recognition and Perception
- Axon Guidance and Neuronal Signaling
- Pharmacological Effects and Assays
- Advanced Memory and Neural Computing
- Diet and metabolism studies
- Advanced Neuroimaging Techniques and Applications
- Cognitive and developmental aspects of mathematical skills
- Fetal and Pediatric Neurological Disorders
- Creativity in Education and Neuroscience
- Adipose Tissue and Metabolism
- Cell Image Analysis Techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Retinal Development and Disorders
- Epilepsy research and treatment
National Center of Neurology and Psychiatry
2013-2024
Osaka University
1996-2017
Ube Frontier University
2009
Spinogenesis and synaptic pruning during development are widely believed to subserve connectional specificity in the mature CNS via Hebbian-type reinforcement. Refinement of neuronal circuit through this “use it or lose it” principle is considered critical for brain development. Here we demonstrate that magnitude spinogenesis basal dendritic trees pyramidal cells differ dramatically among sensory, association, executive cortex. Moreover, somewhat counterintuitively, primary visual area...
Abstract Autism spectrum disorder (ASD) is a multifactorial with characteristic synaptic and gene expression changes. Early intervention during childhood thought to benefit prognosis. Here, we examined the changes in cortical synaptogenesis, function, from birth juvenile stage marmoset model of ASD induced by valproic acid (VPA) treatment. postnatally, synaptogenesis was reduced this model, while juvenile-age VPA-treated marmosets showed increased similar observations human tissue. During...
Abnormalities in the processes of generation and/or pruning dendritic spines have been implicated several mental disorders including autism and schizophrenia. We chosen to examine common marmoset (Callithrix jacchus) as a primate model explore processes. As first step, we studied postnatal development basal trees layer-III pyramidal cells primary visual sensory cortex (V1), association (inferior temporal area, TE), prefrontal (area 12, PFC). Basal dendrites all three areas were longer...
Pyramidal cells grow and mature at different rates among cortical areas in the macaque monkey. In particular, differences across have been reported both timing magnitude of growth, branching, spinogenesis, pruning basal dendritic trees layer III. Presently available data suggest that these growth profiles reflect type functions performed by adult brain. However, to date, studies focused on only a relatively few areas. present investigation we quantified III pyramidal anterior ventral portion...
Neocortical pyramidal cells are characterized by markedly different structure among cortical areas in the mature brain. In ventral visual pathway of adult primates, become increasingly more branched and spinous with anterior progression through primary (V1), second (V2), fourth (V4) cytoarchitectonic TEO TE. It is not known how these regional specializations neuron develop. Here, we report that basal dendritic trees layer III V1, V2, V4, TEO, TE were unique growth profiles. Different numbers...
Pyramidal cells in the primate cerebral cortex, particularly those layer III, exhibit regional variation both time course and magnitude of postnatal growth pruning dendrites spines. Less is known about development pyramidal cell spines other cortical layers. Here we studied dendritic morphology layer-V primary visual cortex (V1, sensory), cytoarchitectonic area TE inferotemporal (sensory association), granular prefrontal (Walker's 12, executive) macaque monkeys at ages 2 days, 3 weeks, 3.5...
In autism spectrum disorder (ASD), disrupted functional and structural connectivity in the social brain has been suggested as core biological mechanism underlying recognition deficits of this neurodevelopmental disorder. study, we aimed to identify genetic neurostructural abnormalities at birth a non-human primate model ASD, common marmoset with maternal exposure valproic acid (VPA), which reported display deficit adulthood. Using comprehensive gene expression analysis, found that 20 genes...
Neurons in the mammalian primary visual cortex (V1) are systematically arranged across cortical surface according to location of their receptive fields, forming a visuotopic (or retinotopic) map. Within this map, foveal field is represented by large area, with increasingly peripheral fields gradually occupying smaller areas. Although cellular organization retina, such as spatial distribution ganglion cells, can partially account for eccentricity-dependent differences size representation,...
Abstract Alterations in the experience-dependent and autonomous elaboration of neural circuits are assumed to underlie autism spectrum disorder (ASD), though it is unclear what synaptic traits responsible. Here, utilizing a valproic acid–induced ASD marmoset model, which shares common molecular features with idiopathic ASD, we investigate changes structural dynamics tuft dendrites upper-layer pyramidal neurons adjacent axons dorsomedial prefrontal cortex through two-photon microscopy. In...
Abstract Autism spectrum disorder (ASD) is a synapse-related that diagnosed at around 3 years of age. Earlier intervention desirable for better ASD prognosis; however, there limited biological literature regarding early-age ASD. This study aimed to assess altered cortical synapses and gene expression in the model marmoset. There were distinct phenotypes animals across neonate, childhood, mature stages dorsomedial prefrontal cortex (Brodmann area 8b/9). At neonate stage, underdeveloped...
ABSTRACT Alterations in the experience-dependent and autonomous elaboration of neural circuits are assumed to underlie autism spectrum disorder (ASD), though it is unclear what synaptic traits responsible. Here, we used a valproic acid-induced ASD marmoset model, which shares common molecular features with idiopathic ASD, investigate structural dynamics tuft dendrites upper-layer pyramidal neurons adjacent axons dorsomedial prefrontal cortex using two-photon microscopy. In model marmosets,...