A5101457709- Neuroscience and Neuropharmacology Research
- Radiation Effects and Dosimetry
- Neuroendocrine regulation and behavior
- Atomic and Molecular Physics
- Memory and Neural Mechanisms
- Particle accelerators and beam dynamics
- Nuclear physics research studies
- Nuclear Physics and Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Ion-surface interactions and analysis
- Muscle Physiology and Disorders
- Ion channel regulation and function
- Electron and X-Ray Spectroscopy Techniques
- Receptor Mechanisms and Signaling
- Advanced Chemical Physics Studies
- Stress Responses and Cortisol
- Amino Acid Enzymes and Metabolism
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Orthopedic Infections and Treatments
- Neuropeptides and Animal Physiology
- Radiomics and Machine Learning in Medical Imaging
- Photoreceptor and optogenetics research
- GDF15 and Related Biomarkers
National Center of Neurology and Psychiatry
2015-2025
Tokyo University of Science
1963-2025
Tokyo Metropolitan Industrial Technology Research Institute
2008-2024
National Institute of Mental Health
2022
Toho University
2002-2020
RELX Group (Netherlands)
2020
Toho University Omori Medical Center
2018
NTT (Japan)
2016
Japan Agency for Medical Research and Development
2016
Japan Science and Technology Agency
2007-2014
Abstract: We compared the activity of free d ‐Ser on potentiation cloned NMDA receptors with that Gly by using a Xenopus oocyte expression system. The extracellular concentration and was further studied means microdialysis. ED 50 values were three to four times lower than those in any combination ε1, ε2, ε3, or ε4 ζ1. Site‐directed mutagenesis ζ1 subunits revealed some aromatic residues necessary for action affected value ‐Ser. This result showed play crucial roles In vivo microdialysis...
Duchenne muscular dystrophy (DMD) is a lethal X-linked disorder caused by mutations in the dystrophin gene, which encodes cytoskeletal protein, dystrophin. Creatine kinase (CK) generally used as blood-based biomarker for disease including DMD, but it not always reliable since easily affected stress to body, such exercise. Therefore, more biomarkers of have long been desired. MicroRNAs (miRNAs) are small, ∼22 nucleotide, noncoding RNAs play important roles regulation gene expression at...
$K$ x rays emitted from $2.1\mathrm{keV}/\mathrm{u}\phantom{\rule{0ex}{0ex}}{\mathrm{N}}^{6+}$ ions passed through a thin Ni microcapillary foil were measured in coincidence with the exit charge states. Ions hole but several electrons outershells, i.e., hollow formed above surface (in first generation), successfully extracted vacuum. It was found that considerable fraction of had extremely long lifetimes order ns.
Duchenne muscular dystrophy (DMD) is accompanied by cognitive deficits and psychiatric symptoms. In the brain, dystrophin, protein responsible for DMD, localized to a subset of GABAergic synapses, but its role in brain function has not fully been addressed. Here, we report that defensive behaviour, response danger or threat, enhanced dystrophin-deficient mdx mice. Mdx mice consistently showed potent freezing responses brief restraint never induced such wild-type Unconditioned conditioned...
We report that a novel sulfonylamino compound, 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetam ide (PEPA), selectively potentiates glutamate receptors of the AMPA subtype. PEPA (1-200 microM) dose dependently potentiated glutamate-evoked currents in Xenopus oocytes expressing (GluRA-GluRD), but not kainate (GluR6 and GluR6+KA2) or NMDA (zeta1 + epsilon1-epsilon4), receptor subunits. was effective at micromolar concentrations and, contrast to action cyclothiazide,...
Contextual fear memory is attenuated by the re-exposure of mice to context without aversive stimulus. This phenomenon called extinction. Here, we report that a potentiator AMPA receptors, 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluorophenoxyacetamide (PEPA), potently facilitates extinction learning in mice. C57BL/6J were exposed novel and stimulated electrical footshock. After 24 h (extinction training) 72 test), repeatedly footshock duration their freezing response was measured. The test...
Impairments in synapse development are thought to cause numerous psychiatric disorders. Autism susceptibility candidate 2 (AUTS2) gene has been associated with various disorders, such as autism and intellectual disabilities. Although roles for AUTS2 neuronal migration neuritogenesis have reported, its involvement regulation remains unclear. In this study, we found that excitatory synapses were specifically increased the Auts2-deficient primary cultured neurons well Auts2 mutant forebrains....
Abstract Stress increases the risk of neuropsychiatric disorders, such as major depression. Exposure to stress has been reported induce various neuronal changes, alterations in synaptic transmission and structure. However, a causal link between stress-induced neural circuit changes emotional behaviours is not well understood. In present study, we focused on projection pathway from orbitofrontal cortex (OFC) basolateral nucleus amygdala (BLA) crucial for negative emotions examined effect...
Abstract Autism spectrum disorder (ASD) is a multifactorial with characteristic synaptic and gene expression changes. Early intervention during childhood thought to benefit prognosis. Here, we examined the changes in cortical synaptogenesis, function, from birth juvenile stage marmoset model of ASD induced by valproic acid (VPA) treatment. postnatally, synaptogenesis was reduced this model, while juvenile-age VPA-treated marmosets showed increased similar observations human tissue. During...
Abstract α‐amino‐hydroxy‐5‐methyl‐isoxazole‐4‐propionate (AMPA) receptor in rat cultured microglia were analyzed precisely using flop‐ and flip‐preferring allosteric modulators of AMPA receptors, 4‐[2‐(phenylsulfonylamino)ethylthio]‐2,6‐difluoro‐phenoxyacetamide (PEPA) cyclothiazide (CTZ), respectively. Glutamate (Glu)‐ or kainite (KA)‐induced currents completely inhibited by a specific blocker receptor, LY300164, indicating that functional Glu‐receptors are mostly but not KA many cells....
Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a component of the ubiquitin system, which has fundamental role in regulating various biological activities. However, functional system neurogenesis not known. Here we show that UCH-L1 regulates morphology neural progenitor cells (NPCs) and mediates neurogenesis. was expressed cultured NPCs as well embryonic brain. Its expression pattern ventricular zone (VZ) changed between day (E) 14 E16, corresponds to transition from gliogenesis. At E14,...
Overexpression of ubiquitin C-terminal hydrolase L1 (UCH-L1) in mice rescues amyloid beta-protein-induced decreases synaptic plasticity and memory. However, the physiological role UCH-L1 brain is not fully understood. In present study, we investigated by utilizing gracile axonal dystrophy (gad) with a spontaneous deletion gene Uch-l1 as loss-of-function model. Although gad exhibit motor paresis beginning at approximately 12 weeks age, it possible to analyse their phenotypes younger age when...
Glutamate is the major excitatory neurotransmitter in brain, and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) mediate majority of postsynaptic depolarization. AMPAR ion channels display rapid gating, their deactivation desensitization determine timing synaptic transmission. potentiators slow channel desensitization, these compounds represent exciting therapies for mental neurodegenerative diseases. Previous studies showed that...
Here, we show neuronal inactivation-induced presynaptic remodeling and involvement of the mammalian homolog Diaphanous (mDia) Rho-associated coiled-coil-containing kinase (ROCK), Rho-regulated modulators actin myosin, in this process. We find that social isolation induces inactivation nucleus accumbens (NAc) neurons associated with elevated anxiety-like behavior, mDia NAc is essential Upon cultured neurons, circumferential filaments around edge synaptic cleft, which contract terminals a...
Little is known about the relationship between Becker Muscular Dystrophy (BMD) and mental disorders. This study aimed to clarify whether BMD a risk factor for psychiatric diseases. We asked genetically or immunohistochemically confirmed patients participate in interview. Participants who consented tests underwent further assessments of intellectual, psychological, neurodevelopmental In total, 76 (73%) 105 (median age, 37 years) completed Of these, 6 had developmental disorders (mental...
Duchenne muscular dystrophy (DMD) is a muscle disorder caused by DMD mutations and characterized neurobehavioural comorbidities due to dystrophin deficiency in the brain. The lack of Dp140, short isoform, clinically associated with intellectual disability autism spectrum disorders (ASDs), but its postnatal functional role not well understood. To investigate synaptic function presence or absence brain we utilized two mouse models, mdx23 mdx52 mice, which Dp140 preserved lacking, respectively....
J. Neurochem. (2011) 119 , 785–790. Abstract β‐Lactotensin (His‐Ile‐Arg‐Leu) is a bioactive peptide derived from bovine milk β‐lactoglobulin, acting as natural agonist for neurotensin receptors. We found that β‐lactotensin exhibited anxiolytic‐like activity in an elevated plus‐maze test after its intraperitoneal (i.p.) administration mice. was also orally active. The of i.p. blocked by levocabastine, antagonist the NTS 2 receptor. had wild‐type but not Ntsr2 ‐knockout increased intracellular...