A5009399227- Menstrual Health and Disorders
- Endometriosis Research and Treatment
- Health and Wellbeing Research
- Uterine Myomas and Treatments
- Biochemical effects in animals
- Healthcare and Venom Research
- Stress Responses and Cortisol
- Ovarian cancer diagnosis and treatment
- Maternal Mental Health During Pregnancy and Postpartum
- Menopause: Health Impacts and Treatments
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Intraperitoneal and Appendiceal Malignancies
- Curcumin's Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Appendicitis Diagnosis and Management
- Phytoestrogen effects and research
- Cytokine Signaling Pathways and Interactions
- PI3K/AKT/mTOR signaling in cancer
- Family Support in Illness
- Estrogen and related hormone effects
- Complementary and Alternative Medicine Studies
- Inflammatory Bowel Disease
- Metabolism, Diabetes, and Cancer
- Microscopic Colitis
Osaka University
2006-2025
Kindai University
2016-2025
Women's Health Research Institute
2013-2025
Minoh City Hospital
2025
Tokushima University
2024
Japanese Red Cross Kochi Hospital
2023
Tohoku University
2010-2022
Kindai University Hospital
2021
Takeda (France)
2019
Osaka National Hospital
2015-2018
Glucose transporter 1 (GLUT1) plays an important role in the transport of glucose placenta. During early pregnancy, placentation occurs a relatively hypoxic environment that is essential for appropriate embryonic development, and GLUT1 expression enhanced response to oxygen deficiency Hypoxia-inducible factor-1 (HIF-1)alpha involved induction other cells. The present study was designed test whether HIF-1alpha hypoxia-induced activation using trophoblast-derived human BeWo rat Rcho-1 cells as...
Estrogen exerts a variety of effects not only on female reproductive organs but also nonreproductive organs, including adipose tissue. inhibits obesity triggered by ovariectomy in rodents. We studied the mechanism underlying this estrogen-dependent inhibition obesity. markedly decreased amounts fat accumulation and lipoprotein lipase (LPL) mRNA as well triglyceride genetically manipulated 3T3-L1 adipocytes stably expressing estrogen receptor (ER). A pLPL(1980)-CAT construct, along with an ER...
Interleukin-6 (IL-6) activation of the immediate-early gene junB has been shown to require both a tyrosine kinase and an unknown 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7)-sensitive pathway. Here we report identification characterization IL-6 response element in promoter (designated JRE-IL6) HepG2 cells. The JRE-IL6 element, located at -149 -124, contains two DNA motifs, Ets-binding site (EBS) (CAGGAAGC) CRE-like (TGACGCGA). Functional studies using variously mutated elements showed...
<i>Background/Aims:</i> Uterine leiomyomas are the most common gynecological benign tumor and greatly affect reproductive health well-being. The pathophysiology epidemiology of fibroids poorly understood. Obesity elevated blood pressure have been reported to be predisposing factors. In this study, we investigated whether associated with some criteria metabolic syndrome. <i>Methods:</i> case patients were 213 women who underwent hysterectomy or myomectomy for fibroids,...
Cytokines and steroid hormones use different sets of signal transduction pathways, which seem to be unrelated. Interleukin-6 (IL-6) uses JAK tyrosine kinase STAT (signal transducer activator transcription) transcription factor. Glucocorticoid binds glucocorticoid receptor (GR), is a member the superfamily. We have studied crosstalk between IL-6-JAK-STAT glucocorticoid-nuclear pathways. IL-6 synergistically activated response element on rat alpha2-macroglobulin promoter (APRE)-driven...
Introduction: The aim of this study was to identify the prognostic factors and establish a model for prediction life expectancy in patients with recurrent cervical cancer that had previously been treated radiotherapy. Methods: records consecutive women after radiotherapy were retrospectively reviewed. Primary disease, follow-up, recurrence data collected. Univariate multivariate analyses survival performed. Results: A total 162 included our database. median 15 months. Multivariate analysis...
Premenstrual disorders such as premenstrual syndrome (PMS) and dysphoric disorder (PMDD) interfere with the daily lives of adolescents. The causes PMS PMDD are unknown, but lifestyle habits, regular exercise taste preference known to be associated. This study was conducted investigate how symptoms affect school life in Japanese high students whether there a risk factor for absenteeism that is dependent on types or habits.A school-based survey Sendai, an industrial city Japan. A total 901...
Uterine leiomyosarcoma (LMS) has an unfavorable response to standard chemotherapy. A natural occurring compound, curcumin, been shown have inhibitory effects on cancers. We previously demonstrated that curcumin reduced uterine LMS cell proliferation by targeting the AKT-mTOR pathway and activating apoptosis. To further explore anticancer effect of we investigated efficacy autophagy in cells.Cell human lines, SKN SK-UT-1, was assessed after exposure rapamycin or curcumin. Autophagy detected...
To investigate the current status and problems in diagnosis treatment of premenstrual syndrome (PMS) dysphoric disorder (PMDD) from perspective obstetricians gynecologists (OB/GYNs) Japan, Japanese Society Obstetrics Gynecology (JSOG) conducted a national-wide survey.An email survey was sent to all JSOG members (16 732) web-based using Google form between September November 2021. The PMS/PMDD were surveyed this cross-sectional study.In total, 1312 respondents (7.8% members) completed...
Abstract During early pregnancy, cytotrophoblast cells differentiate into extravillous trophoblast (EVT) and invade the uterine spiral arteries. This physiological process is essential for development of maternal-fetal circulation. Because EVT are exposed to a low-oxygen environment during this process, we investigated role hypoxia in mechanism that regulates invasive behavior cells. Real-time PCR immunofluorescent analysis were performed investigate how influences expression E-cadherin...
In Brief BACKGROUND: Leiomyomatosis peritonealis disseminata is a rare disease characterized by multifocal proliferation of smooth muscle-like cells that are histologically similar to uterine leiomyoma. High levels female gonadal steroids considered play an important role in the pathogenesis leiomyomatosis disseminata. CASE: A 68-year-old woman was referred our hospital for pelvic tumor and multiple intraabdominal solid masses. After laparotomy, she diagnosed as having Most disseminated...
On March 11, 2011, the Great East-Japan Earthquake occurred and a massive tsunami hit northeastern coast of Japan. Catastrophic disasters such as earthquakes war cause tremendous damage, not only physically but also mentally. Posttraumatic stress disorder (PTSD) is an anxiety that occurs in aftermath traumatic event. Premenstrual syndrome (PMS) cluster psychological somatic symptoms are limited to late luteal phase menstrual cycle. dysphoric (PMDD) considered severe form PMS. To determine...
Abstract Background In Japan, 'addiction' is highly stigmatized, leading to the avoidance of analgesics due concerns about addiction (Purnell 2019). Furthermore, there a cultural belief in Japan that emphasizes enduring pain as virtue These contexts related contribute attitudes toward Japan. Aims & Objectives This study aimed investigate situation among Japanese women who do not use any for menstrual pain, concerning their and fear dependence. Additionally, examine endurance practices...