A5089379970- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Eating Disorders and Behaviors
- Functional Brain Connectivity Studies
- Neurological Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Amyotrophic Lateral Sclerosis Research
- Down syndrome and intellectual disability research
- Attention Deficit Hyperactivity Disorder
- Cholinesterase and Neurodegenerative Diseases
- Cerebrospinal fluid and hydrocephalus
- CRISPR and Genetic Engineering
- Psychological Treatments and Disorders
- Chronic Disease Management Strategies
- Literacy and Educational Practices
- Local Governance and Development
- Healthcare Systems and Public Health
- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Psychology Research and Bibliometrics
- BRCA gene mutations in cancer
- Developmental and Educational Neuropsychology
- Aging, Health, and Disability
- Parkinson's Disease Mechanisms and Treatments
- Pluripotent Stem Cells Research
Instituto de Neurología Cognitiva
2014-2025
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
2014-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2021
Centro Científico Tecnológico - San Juan
2016
Purpose To describe results of the Amyloid, Tau, Neurodegeneration (ATN) research framework classification in Argentine-Alzheimer's Disease Neuroimaging Initiative (arg-ADNI) cohort. Methods Twenty-three patients with mild cognitive impairment (MCI), 12 dementia Alzheimer's type (DAT), and 14 normal controls were studied following ADNI2 protocol. Patients categorized according to presence or absence biomarkers for amyloid beta (Aβ; A: positron emission tomography [PET] scan cerebrospinal...
The purpose of this study was to investigate the relationship between cognitive reserve and concentration Aβ1-42 in cerebrospinal fluid (CSF) patients with mild impairment, those Alzheimer's disease, control subjects.Thirty-three participants from Argentina-Alzheimer's Disease Neuroimaging Initiative database completed a battery, Cognitive Reserve Questionnaire (CRQ), an Argentinian accentuation reading test (TAP-BA) as measure premorbid intelligence, underwent lumbar puncture for CSF...
ABSTRACT The Argentina-Alzheimer's disease neuroimaging initiative (Arg-ADNI) study is a longitudinal prospective cohort of 50 participants at single institution in Buenos Aires, Argentina. Longitudinal assessments on neuropsychological test battery were performed 15 controls, 24 mild cognitive impairment (MCI) patients and 12 Alzheimer's (AD) dementia patients. In our population, there was high prevalence positive AD biomarkers the group, 92.3% (12/13); low normal 20%; almost half (48%)...
Abstract Objective Previous studies have shown theory of mind (ToM) is affected in patients with anorexia nervosa (AN). There has also been growing interest the study endophenotypes psychiatric disorders, since they allow better understanding genetic mechanisms underlying different conditions, making them potential targets for future treatment. The goal this was to investigate whether ToM inefficiencies observed AN, are shared by unaffected first‐degree relatives. Method Performance on two...
We present a female patient aged 51 who developed behavioral disorders followed by cognitive impairment over 3 years. Neuropsychological, neuropsychiatric, and radiological features suggested probable variant of frontotemporal dementia (bvFTD). A family history amyotrophic lateral sclerosis parkinsonism the hexanucleotide repeat expansion G4C2 in C9ORF72 . set up two-step genotyping algorithm for detection using fragment-length analysis polymerase chain reaction (PCR) repeat-primed PCR with...
Los trastornos alimentarios (TA) afectan predominantemente a mujeres jovenes generando un sensible impacto en la salud y calidad de vida. En estos existen alteraciones el funcionamiento cognitivo que se asocian tanto persistencia como peor pronostico enfermedad. Pese esto, nuestro medio, perfil las pacientes con TA ha sido poco explorado. El objetivo este trabajo fue estudiar neuropsicologico grupo argentinas anorexia nerviosa (AN) bulimia (BN) comparacion participantes control sanos (CS)....
Abstract Background Down Syndrome (DS) is the most common genetic form of intellectual disability. In recent years, there has been a significant increase in life expectancy individuals with DS, currently reaching age 60 or over. However, it observed that as 40, these experience higher risk developing dementia, and almost all them exhibit histopathological characteristics Alzheimer's disease (AD) their brains. As part first Latin American initiative for study Alzheimer’s adults syndrome...
Objective: To show a cognitive ALS pattern with principal focus on social cognition. Background: Cognitive impairment and Amyotrophic Lateral Sclerosis is described association but still remains undefined as clear clinical syndrome. Due to the close relationship (clinic genetical) frontotemporal lobar degeneration, cognition involvement could be significant nonmotor feature of this disease. Methods: Cross-sectional study 23 patients recently diagnosed (less than year) probable or definite...
Life expectancy of individuals with Down Syndrome (DS) is currently 60 years. From age 40 they have an increased risk dementia and almost all them histopathological features Alzheimer's disease (AD) in their brains. Also, it known that the ε4 allele APOE gene R47H variant TREM2 increase AD. DS also associated a group clinical manifestations accelerated aging. DNA methylation-based biomarkers ageing (epigenetic clocks) can be assessed by different models. It methylation (DNAm) has positive...
OBJECTIVE: To describe related factors to conversion from CDR 0,5 1 in the ADNI-Arg population BACKGROUND: Alzheimer disease (AD) represents most frequent cause of dementia worldwide, knowledge about this disorder have increased dramatically during last decade. ADNI is one projects that contributed achievement; using a multimodal approach including neuropsychological assessment, Magnetic Resonance Imaging (MRI) and biomarkers such as PET Scan, Cerebrospinal Fluid (CSF): Amyloid protein...
The Argentina- Alzheimer's Disease Neuroimaging Initiative (Arg-ADNI) study is a longitudinal prospective cohort of 60 participants at single institution from Buenos Aires, Argentina. Arg-ADNI the first worldwide ADNI center in Latin America and Hispanic community-dwelling subjects worldwide. Baseline assessments have been done on 15 normal controls, 28 mild cognitive impairment (MCI) 13 AD dementia subjects, with 4 lost to follow-up. For Arg-ADNI, magnetic resonance imaging (MRI),...
It is important for elderly patients with cognitive impairment to assess the impact that memory loss has on functional capacity of everyday activities. Performance these activities directly related independent living and need care. Systematic assessment appropriate scales thus an clinical research issue. The Everyday Cognition (ECog) scale a relatively new informant subjective-rated measure instrumental daily function. objective this study was determine validity internal consistency...
In elderly patients with cognitive impairment is it important for diagnostic and clinical issues to assess objectively the functional activities of every day. present study, we aimed explore existence an association between status based on assessment informant- ECog score presence brain amyloid, using PiB-PET imaging, from Argentina-ADNI cohort. All participants were enrolled in study. Fifty subjects included analysis, 13 whom have a current diagnosis mild Alzheimer's disease (AD) dementia,...
Abstract Background In recent years, there has been an increase in the number of case reports families with autosomal dominant Alzheimer’s disease (ADAD) Latin America (LA). Nevertheless, little is known about clinical phenotypes and demographic characteristics mutations each country. Past literature proved that variants LA have different unique than those reported Asia, North America, Europe. Clinical heterogeneity ADAD supports need to study phenotypes, especially preclinical stages,...
Abstract Background Down Syndrome [DS] is the most frequent cause of genetic developmental and intellectual disability. The lifetime risk Alzheimer’s Disease [AD] in people with DS more than 90%, an earlier age onset general population. There ongoing debate whether there are significant differences dementia presentation specific context DS, some studies suggesting a predominantly frontal phenotype behavioural symptoms others amnestic presentation. aim this study was to characterize initial...
Persons with Down Syndrome (DS) are at high risk of dementia because Alzheimer's Disease (AD-DS). Considering the growing evidence on influence lifestyle, socioeconomical and educational aspects in incidence development general population, assessment these factors people DS population becomes utmost importance. Epidemiological studies Latin America scarce. The aim this study is to assess sociodemographical Argentinian compare it available data from other countries. Information derives...
Alzheimer's Disease (AD) is not only more frequent and has an earlier onset in Down Syndrome (DS) than the general population, but also atypical clinical phenotype uncertain genetic risk factor biomarker profile. The aim of this study to investigate clinical, aspects AD DS. Longitudinal 3-year follow-up 20 symptomatic asymptomatic subjects with DS aged between 18 60 years-old by means cognitive assessment (Camdex-DS), brain MRI, FDG PiB-PET, CSF levels Aβ42, phosphorylated τ total τ,...