A5078644282- Air Quality and Health Impacts
- Health, Environment, Cognitive Aging
- Noise Effects and Management
- Carcinogens and Genotoxicity Assessment
- Asthma and respiratory diseases
- Nutritional Studies and Diet
- Energy and Environment Impacts
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Birth, Development, and Health
- Nutrition and Health in Aging
- Healthcare and Environmental Waste Management
- Neonatal Respiratory Health Research
- Multi-Criteria Decision Making
- Pharmaceutical industry and healthcare
- Data-Driven Disease Surveillance
- Urban Transport and Accessibility
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmaceutical Economics and Policy
- Biomedical Text Mining and Ontologies
- Obesity, Physical Activity, Diet
- Multiple Myeloma Research and Treatments
- Colorectal Cancer Treatments and Studies
- Reproductive Health and Contraception
- Air Quality Monitoring and Forecasting
IQVIA (United Kingdom)
2020-2022
ASL Roma
2018-2020
Azienda Sanitaria Locale Roma 3
2014-2019
Servizio Sanitario Nazionale
2018
Regione Lazio
2010-2017
Regione Campania
2013-2017
Center for Research in Environmental Epidemiology
2015
Regional Health
2015
Agenzia Regionale per la Protezione dell'ambiente ligure
2012
Agenzia Regionale Parchi
2010
Early life exposure to air pollution has been linked with cognitive impairment in children, but the results have not conclusive. We analyzed association between traffic-related and function a prospective birth cohort Rome.A of 719 newborns was enrolled 2003-2004 as part GASPII project. At age 7 years, 474 children took Wechsler Intelligence Scale for Children-III assess their development terms IQ composite scores. Exposure pollutants (NO2, PMcoarse, PM2.5, PM2.5 absorbance) at assessed using...
While there is evidence for variations in prevalence rates of childhood wheeze and asthma between countries, longitudinal, individual-level data are needed to understand these differences. The aim this study was examine asthma, with Europe. We analysed datasets from 10 MeDALL (Mechanisms the Development ALLergy) cohorts eight representing 26 663 children, calculate by child age at 4 years. Harmonised variables included outcomes parent-reported doctor-diagnosed covariates maternal education,...
The fetal and infant life are periods of rapid development, characterized by high susceptibility to exposures. Birth cohorts provide unique opportunities study early-life exposures in association with child development health, as well as, longer follow-up, the early origin adult diseases. Piccolipiù is an Italian birth cohort recently set up investigate effects environmental exposures, parental conditions social factors acting during pre-natal post-natal on health development. We describe...
The European post-authorisation study (EU PAS) register is a repository launched in 2010 by the Medicines Agency (EMA). All EMA-requested PAS, commonly observational studies, must be recorded this register. Multi-database studies (MDS) leveraging secondary data have become an important strategy to conduct PAS recent years, as reflected type of registered EU To analyse and describe register, with focus on MDS. Studies from inception 31st December 2018 were described concerning transparency,...
A chemical plant manufacturing pesticides has been operating since the 1950’s in Sacco River Valley (Central Italy). In 2005, high beta-hexachlorocyclohexane (Beta-HCH) concentrations were found milk of cows raised and fed near river. We report results a biomonitoring study conducted this region to evaluate body burden Beta-HCH identify determinants human contamination. defined four residential areas by their distance from river, selected stratified random sample 626 people aged 25–64 years....
The numbers of international collaborations among birth cohort studies designed to better understand asthma and allergies have increased in the last several years. However, differences definitions methods preclude direct pooling original data on individual participants. As part Mechanisms Development Allergy (MeDALL) Project, we harmonized from 14 (each with 3–20 follow-up periods) carried out 9 European countries during 1990–1998 or 2003–2009. harmonization process followed 6 steps: 1)...
Abstract Background Hexachlorocyclohexane is a synthetic chemical with several isomers, including β-Hexachlorocyclohexane (β-HCH). In 2005, large contamination of crude milk from some bovine farms along the Sacco River (Central Italy) was detected; it related to illegal disposal quantities processing waste by industry area. A biomonitoring study, conducted in 2007 on sample residing population, found high values β-HCH people living close river. These results led establishment clinical and...
Abstract Purpose Define patients treated with evidence‐based drugs in a cohort discharged after acute myocardial infarction (AMI) absence of prescribed daily doses (PDD). To compare different drug use measures and analyze their impact on the effect estimate risk factors related to use. Methods AMI Rome during 2006–2007 were selected from Hospital Information System. Drugs claimed 12 months discharge retrieved. Measures defined as: ‘ continuity ’ (one prescription each follow‐up quarter‐year)...
Involuntary weight loss may occur during systemic anti-cancer therapy (SACT), causing treatment disruption and poorer prognoses. There remain gaps in clinical awareness as to which patients benefit from nutritional interventions that aim prevent unintended SACT.We utilised England's population-level cancer registry data, conducting a pan-cancer assessment of patient SACT. We aimed identify cancers with loss-associated modifications, potential beneficiaries intervention.This cross-sectional...
The identification of novel molecules associated with asthma may provide insights into the mechanisms disease and their potential clinical implications.
In Italy, direct oral anticoagulant drugs (DOACs) were authorized for stroke prevention in patients with non-valvular atrial fibrillation (NVAF) 2013. There is conflicting evidence on their benefit-risk profile under real world conditions.The Italian Medicines Agency funded this study to investigate effectiveness and safety of DOACs compared vitamin K antagonists (VKAs) three regions. An observational was conducted a sequential propensity-score-matched new user parallel-cohort design the...
to test the validity of algorithms identify diabetes, chronic obstructive pulmonary disease (COPD), hypertension, and hypothyroidism from routinely collected health data using information self-reported diagnosis laboratory or functional test.clinical three surveys conducted in Lazio Region (Central Italy) between year 2010 2014 were assumed as gold standard compared results application administrative data.prevalence resulted available compared. Sensitivity, specificity, positive predictive...
Association between Traffic-Related Air Pollution and Cognitive Development in a Prospective Italian Birth CohortAbstract Number:2332 Daniela Porta, Silvia Narduzzi, Giulia Cesaroni, Chiara Badaloni, Valentina Colelli, Joel Schwartz, Francesco Forastiere* Porta Department of Epidemiology Lazio Regional Health System, Italy, E-mail Address: [email protected] , Narduzzi Cesaroni Badaloni Colelli Schwartz Harvard School Public Health, United States, AbstractIntroduction. Early life exposure to...
In birth cohort studies, borderline associations have been reported between traffic-related air pollution and otitis, pneumonia in children. However, the evidence is still scarce, especially for infants. We aimed to explore of land-use variables at respiratory infections infants participating ongoing prospective Piccolipiù recruited 5 centers Italy. Of 3337 enrolled, 2698 were studied 12 months 1976 24 age. Occurrence recurrent upper (URI) including lower (bronchiolitis, bronchitis,...
Accumulating evidence suggests that maternal exposure to air pollution during pregnancy affects birth outcomes, mainly increasing the risk of low weight, but implications for postnatal growth are unclear. We aimed assess effect land-use variables at birth, used as proxy pollution, on weight trajectories in infancy. included 2841children from multicentre Piccolipiù cohort. studied associations between meters distance major road, population density (square and high 0.5km buffer), urban green...
Introduction Large cohorts based on administrative data have addressed the role of long-term exposure to air pollution mortality. However, individual lifestyle factors are usually missing in such studies and a causal modeling approach investigate association has not been used. The propensity scores approach, potential outcomes framework, allows use substantial number correlated covariates that might overcome these limitations. Methods A cohort more than 1 million adults was followed from...
Second hand smoking (SHS) has been found associated with sleep patterns through respiratory diseases such as asthma and rhinitis. Among other short duration number of night...
Background: Previous studies have found an association between exposure to air pollution and urban green in the first years of life neurodevelopment children, but results are not conclusive. We analysed land-use variables at birth, as a proxy for pollution, 12 24 months Italy. Methods: A cohort newborns was enrolled from 2011-2015 part PICCOLIPIÙ project. To assess neurodevelopment, parents responded seven specific items Parca-R scale (non-verbal development) 12- 24-month questionnaires,...