A5003489579- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Tracheal and airway disorders
- Lipid metabolism and disorders
- Voice and Speech Disorders
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Head and Neck Cancer Studies
- Axon Guidance and Neuronal Signaling
- HIV/AIDS oral health manifestations
- Diabetes and associated disorders
- Neuroendocrine regulation and behavior
- Myasthenia Gravis and Thymoma
- Diabetes Treatment and Management
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Renal Diseases and Glomerulopathies
- Dysphagia Assessment and Management
- FOXO transcription factor regulation
- Renin-Angiotensin System Studies
- Hepatitis C virus research
- Neuroscience of respiration and sleep
University of Lausanne
2014-2023
Délégation Paris 7
2013-2020
Université Paris Cité
2011-2020
Hôpital Bichat-Claude-Bernard
2017-2020
Assistance Publique – Hôpitaux de Paris
2010-2018
Université Claude Bernard Lyon 1
2017-2018
Centre National de la Recherche Scientifique
2011-2017
Unit of Functional and Adaptive Biology
2017
Sorbonne Paris Cité
2017
SIB Swiss Institute of Bioinformatics
2017
Brain lipid sensing is necessary to regulate energy balance. Lipoprotein lipase (LPL) may play a role in this process. We tested if hippocampal LPL regulated homeostasis rodents by specifically attenuating activity the hippocampus of rats and mice, either infusing pharmacological inhibitor (tyloxapol), or using genetic approach (adeno-associated virus expressing Cre-GFP injected into Lpl (lox/lox) mice). Decreased method led increased body weight gain due decreased locomotor expenditure,...
The counterregulatory response to hypoglycemia, which restores normal blood glucose levels ensure sufficient provision of the brain, is critical for survival. To discover underlying brain regulatory systems, we performed a genetic screen in recombinant inbred mice quantitative trait loci (QTL) controlling glucagon secretion neuroglucopenia. We identified QTL on distal part chromosome 7 and combined this information with transcriptomic analysis hypothalami. This revealed Fgf15 as strongest...
The counterregulatory response to hypoglycemia is an essential survival function. It controlled by integrated network of glucose-responsive neurons, which trigger endogenous glucose production restore normoglycemia. complexity this glucoregulatory is, however, only partly characterized. In a genetic screen panel recombinant inbred mice we previously identified Fgf15, expressed in neurons the dorsomedial hypothalamus (DMH), as negative regulator glucagon secretion. Here, report on generation...
Abstract The counterregulatory response to hypoglycemia that restores normal blood glucose levels is an essential physiological function. It initiated, in large part, by incompletely characterized brain sensing neurons trigger the secretion of hormones, particular glucagon, stimulate hepatic production. In a genetic screen recombinant inbred BXD mice we previously identified Agpat5 as candidate regulator hypoglycemia-induced glucagon secretion. Here, using mouse models, demonstrate expressed...
Glucokinase (Gck) is a critical regulator of glucose-induced insulin secretion by pancreatic β-cells. It has been suggested to also play an important role in glucose signaling neurons the ventromedial hypothalamic nucleus (VMN), brain involved control homeostasis and feeding. To test Gck VMN sensing physiological regulation, we studied mice with genetic inactivation gene Sf1 (Sf1Gck−/− mice). Compared littermates, Sf1Gck−/− displayed increased white fat mass adipocyte size, reduced lean...
Abstract Nuclear receptor PPARγ has been proven to affect metabolism in multiple tissues, and received considerable attention for its involvement colon cancer inflammatory disease. However, role intestinal largely ignored. To investigate this potential aspect of function, we submitted epithelium-specific knockout mice (iePPARγKO) a two-week period 25% caloric restriction (CR), following which iePPARγKO retained more fat than their wild type littermates. In attempting explain discrepancy,...
Virus-related type 2 diabetes is commonly observed in individuals infected with the hepatitis C virus (HCV); however, underlying molecular mechanisms remain unknown. Our aim was to unravel these using FL-N/35 transgenic mice expressing full HCV ORF. We that displayed glucose intolerance and insulin resistance. also found Glut-2 membrane expression reduced hepatocyte uptake perturbed, partly accounting for HCV-induced mice. Early steps of hepatic signaling pathway, from IRS2 PDK1...
In the pathogenesis of type 2 diabetes, development insulin resistance triggers an increase in pancreatic β-cell secretion capacity and number. Failure this compensatory mechanism is caused by a dedifferentiation β-cells, which leads to insufficient diabetic hyperglycemia. The factors that normally protect against remain poorly defined. Here, through systems biology approach, we identify transcription factor Klf6 as regulator adaptation metabolic stress.We used specific knockout mouse model...
Glucagon secretion to stimulate hepatic glucose production is the first line of defense against hypoglycemia. This response triggered by so far incompletely characterized central hypoglycemia-sensing mechanisms, which control autonomous nervous activity and hormone secretion. The objective this study was identify novel hypothalamic genes controlling insulin-induced glucagon To obtain new information on mechanisms hypoglycemia sensing, we combined genetic transcriptomic analysis in a panel...
Abstract Feeding behavior is a complex process that depends on the ability of brain to integrate hormonal and nutritional signals, such as glucose. One glucosensing mechanism relies glucose transporter 2 (GLUT2) in hypothalamus, especially radial glia-like cells called tanycytes. Here, we analyzed whether GLUT2-dependent required for normal regulation feeding GFAP-positive Genetic inactivation Glut2 GFAP - expressing tanycytes was performed using Cre/Lox technology . The efficiency...
Abstract The counterregulatory response to hypoglycemia (CRR), which ensures a sufficient glucose supply the brain, is an essential survival function. It orchestrated by incompletely characterized glucose‐sensing neurons, trigger coordinated autonomous and hormonal that restores normoglycemia. Here, we investigate role of hypothalamic Tmem117 , identified in genetic screen as regulator CRR. We show expressed vasopressin magnocellular neurons hypothalamus. inactivation these increases...
Proopiomelanocortin (POMC) neurons are major regulators of energy balance and glucose homeostasis. In addition to being regulated by hormones nutrients, POMC controlled glutamatergic input originating from multiple brain regions. However, the factors involved in formation inputs how they contribute bodily functions remain largely unknown. Here, we show that during development inputs, exhibit enriched expression Efnb1 (EphrinB1) Efnb2 (EphrinB2) genes, which known control excitatory synapse...
Disseminated Histoplasmosis (DH) is a rare manifestation of Acquired Immune Deficiency Syndrome (AIDS) in European countries. Naso-maxillar osteolysis due to Histoplasma capsulatum var. (Hcc) unusual endemic countries and has never been reported Differential diagnoses such as malignant tumors, cocaine use, granulomatosis, vasculitis infections are more frequently observed could delay and/or bias the final diagnosis. We report case an immunocompromised patient infected by Human...
Irbesartan (SR 47436, BMS 186295) is an imidazole derivative that specifically binds to the angiotensin type 1 receptor. The purpose of this study was assess inhibitory effect irbesartan on pressor action exogenous II in healthy subjects, evaluate dose dependency and duration inhibition, determine plasma components renin-angiotensin system. Forty-two male volunteers maintained ad libitum sodium intake were enrolled a randomized, double-blind, placebo-controlled, parallel-design, dose-ranging...
Objective: Hypertension is a major cause of cognitive decline even though the underlying mechanisms remain hypothetical. Supporting contribution deficient brain-derived neurotrophic factor (BDNF) signaling, animal studies recently reported low BDNF levels in hippocampus hypertensive rats as compared to their normotensive controls. Besides, physical training that positively associated with cardiovascular health also one most efficient strategies increase brain and performance. These data led...