A5100676782- Reproductive System and Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
- Immune cells in cancer
- Endometriosis Research and Treatment
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Essential Oils and Antimicrobial Activity
- Ovarian function and disorders
- interferon and immune responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bacterial Infections and Vaccines
- Immune Cell Function and Interaction
- Kruppel-like factors research
- Assisted Reproductive Technology and Twin Pregnancy
- Piperaceae Chemical and Biological Studies
- Ophthalmology and Eye Disorders
- Stress Responses and Cortisol
- FOXO transcription factor regulation
- Sepsis Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Maternal and fetal healthcare
- Transgenic Plants and Applications
Soochow University
2014-2025
First Affiliated Hospital of Soochow University
2017-2025
China National Botanical Garden
2023-2024
Guiyang Medical University
2022-2024
Affiliated Hospital of Guizhou Medical University
2022-2024
Chinese Academy of Sciences
2023-2024
Beijing Botanical Garden
2023-2024
Institute of Botany
2023-2024
Hebei General Hospital
2024
Yangzhou University
2022-2023
MicroRNAs (miRNAs) are non-coding RNA molecules of about 22 nucleotides that involved in post-transcriptional gene regulation. Evidence indicates miRNAs play essential roles endometriosis, pre-eclampsia, infertility and other reproductive system diseases. However, whether recurrent spontaneous abortion (RSA) is unclear. In this work, we analysed the miRNA expression profiles six pairs villus or decidua from RSA patients normal pregnancy (NP) women using a human microarray. Some chip results...
The Tol-Pal system of Gram-negative bacteria is necessary for maintaining outer membrane integrity. It a multiprotein complex five envelope proteins, TolQ, TolR, TolA, TolB, and Pal. These proteins were first investigated in E. coli, subsequently been identified many other bacterial genera. However, the function Salmonella Choleraesuis pathogenesis still unclear. Here, we reported role three these phenotype biology S. Choleraesuis. We found that mutations tolA, tolB, tolR caused severe...
Nowadays, the demand for rosemary essential oils (REOs) in cosmetic, food, and pharmaceutical industries is increasing, abundant germplasm resources of provide more possibilities functional applications. The REOs from six cultivars were selected to evaluate compare their bioactivities. have good cellular antioxidant activity scavenging reactive oxygen species, technology order preference by similarity an ideal solution (TOPSIS)-random forest multivariate model indicated that ‘Dutch Mill’ REO...
The excessive apoptosis of human trophoblasts can cause pregnancy‑related diseases. It has been reported that fibronectin 1 (FN1) is closely associated with the invasion trophoblasts. aim present study was to examine effects FN1 on and investigate underlying molecular mechanisms. found FN1, a differentially expressed gene (DEG) in GSE127170 dataset, identified as hub protein‑protein interaction (PPI) network generated using cytoHubba plug‑in Cytoscape software. Metascape website used perform...
Bacterial outer membrane vesicles (OMVs) are considered a promising vaccine platform for their high built-in adjuvanticity and ability to efficiently induce immune responses. OMVs can be engineered with heterologous antigens based on genetic engineering strategies. However, several critical issues should still validated, including optimal exposure the OMV surface, increased production of foreign antigens, nontoxicity, induction powerful protection. In this study, lipoprotein transport...
Repeated implantation failure (RIF) is currently believed by some scholars to be mainly related the poor endometrial receptivity. Three-dimensional (3D) ultrasound, as a noninvasive examination, has attracted most attention. This paper further discusses whether 3D ultrasound of receptivity index guidance value in evaluation pregnancy outcomes patients with RIF following frozen-thawed embryo transfer.A total 79 were retrospectively analyzed. These which confirmed transvaginal ultrasonography...
This study investigates the role of phosphatidylethanolamine cytidylyltransferase 2 (PCYT2) in ovarian epithelial cancer, specifically examining its effects on cell migration and membrane fluidity. To achieve this, we will examine how AMPK FOXO1 pathways regulate these processes. Our analysis revealed a significant upregulation PCYT2 expression metastatic cancer tissues compared to primary sites, which correlates with altered data indicate that is essential for modulating invasive...
The aim of the present study was to investigate underlying mechanisms hypoxia‑induced microRNA (miR)‑210 effects on mouse GC‑2spd (GC‑2) cells. GC‑2 cells were subjected hypoxia or normoxia for 12, 24, 48 and 72 h. Apoptosis detected using terminal deoxynucleotidyl‑transferase‑meditated dUTP nick end labeling flow cytometry. Reverse transcription‑quantitative polymerase chain reaction performed analyze expression miR‑210. Hypoxia‑inducible factor‑1α (HIF‑1α), caspase‑3, B‑cell lymphoma 2,...
MicroRNAs serve important functions in numerous biological processes. Whether microRNAs also act on dendritic cell (DC) differentiation and function remains unclear. In this study, both conventional DCs (cDCs) plasmacytoid (pDCs) were increased miR-34a overexpressing bone marrow chimeric transgenic (TG) mice. Further experiments showed that promoted preDC differentiated into cDCs pDCs without affecting the proliferation apoptosis of DCs. Luciferase report assay Western blot demonstrated WNT1...
Despite the availability of highly effective treatments, there is a significant recurrence rate benign paroxysmal positional vertigo (BPPV). This study aimed to quantitatively measure sleep quality in BPPV patients and correlate it with BPPV.In this longitudinal cohort study, clinical records 67 elderly or middle-aged adult who were diagnosed at Neurology Clinic, Beijing Chaoyang Hospital affiliated Capital Medical University between 2013 2014. The 'recurrent' 'non-recurrent' respectively...
The prevalence and incidence of human immunodeficiency virus type 1 (HIV-1) among men who have sex with (MSM) are on the rise throughout China. With a large population MSM, Jiangsu Province is facing an escalating HIV-1 epidemic. aim this study was to explore phylogenetic temporal dynamics CRF01_AE CRF07_BC antiretroviral therapy (ART)-naïve MSM recently infected in Province. We recruited (Suzhou, Wuxi, Nantong, Taizhou Yancheng) 2012 2015. collected information demographics sexual behaviors...
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of early myeloid progenitors, which possess strong immunosuppressive functions. MDSCs found in increased numbers infectious and inflammatory pathological conditions. However, whether microRNAs have role the expansion remains unclear. Here our study, we that overexpression miR-34a could induce bone marrow spleen both chimera transgenic mice. And further experiments demonstrated inhibited apoptosis through reduced...
Abstract The aim of this study was to investigate the underlying mechanisms hypoxia‐induced apoptosis GC‐2spd (GC‐2) cells. GC‐2 cells were treated with or without hypoxia for 12, 24, 48, and 72 h. Apoptosis detected using TUNEL flow cytometry. Fluorescence microscopic used observe autophagy Hypoxia‐inducible factor‐1alpha (HIF‐1α), apoptosis‐related protein marker levels measured by Western blotting. Hypoxia induced cells, increased expression HIF‐1α, LC3‐II, Beclin‐1, pro‐apoptotic...
Background: Dental fluorosis is a discoloration of the teeth caused by excessive consumption fluoride. It represents distinct manifestation chronic in dental tissues, exerting adverse effects on human body, particularly teeth. The transmembrane protein 16a (TMEM16A) expressed at junction endoplasmic reticulum and plasma membrane. Alterations its channel activity can disrupt calcium homeostasis intracellular ion concentration, thereby inducing stress (ERS). This study aims to investigate...
To investigate the regulatory effect of glycyrrhizin (GL) on release neutrophil extracellular traps (NETs) from neutrophils in sepsis. HL-60 cells were induced to differentiate into neutrophil-like dHL-60 establish a sepsis model. Expression levels high-mobility group box 1 (HMGB1), citrullinated histone H3 (Cit-H3), and Toll-like receptor 9 (TLR9) assessed by Western blotting. Free DNA, component NETs, was quantified using fluorescence microplate reader. Cellular immunofluorescence analysis...