A5062166376- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Bone Tissue Engineering Materials
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Structural Behavior of Reinforced Concrete
- Bone Metabolism and Diseases
- Structural Load-Bearing Analysis
- Advancements in Battery Materials
- Microstructure and Mechanical Properties of Steels
- HER2/EGFR in Cancer Research
- Crystallization and Solubility Studies
- Cell Adhesion Molecules Research
- Carbohydrate Chemistry and Synthesis
- X-ray Diffraction in Crystallography
- Cancer-related gene regulation
- 3D Printing in Biomedical Research
- RNA Research and Splicing
- Lymphoma Diagnosis and Treatment
Liaoning Cancer Hospital & Institute
2012-2025
Texas Tech University
2018-2025
Texas Tech University Health Sciences Center
2018-2025
Jiangxi Normal University
2022-2025
Sun Yat-sen University
2025
Sun Yat-sen University Cancer Center
2025
North University of China
2022-2024
China Medical University
2017-2024
Tianjin Institute of Pharmaceutical Research (China)
2024
Guangdong Academy of Medical Sciences
2024
Oral squamous cell carcinoma (OSCC) is the most frequent oral cancer in world, accounting for more than 90% of all diagnosis. Circular RNAs (circRNAs) are large types non-coding RNAs, demonstrating a great capacity regulating expression genes. However, functions circRNAs still unknown. Recent research revealed that could serve as miRNA-sponge, consequently target genes indirectly, including oncogenes. In this study, we built an apoptotic model with TNF-α, and then confirmed circRNA...
Drug delivery and release are a major challenge fabricating bone tissue engineering. In this study, we fabricated new sustained hydrogel scaffolds composited of mesoporous bioactive glass, sodium alginate gelatin by three-dimensional printing technique. Naringin calcitonin gene-related peptide were used as drugs to prepare drug-loaded direct or surface absorption. The physicochemical properties the drug profiles two drug-loading models investigated. We also examined biocompatibility...
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) increases the risk of cardiovascular and existing evidence indicates that MASLD affects system through systemic inflammation. Our aim was to assess association hematological biomarkers inflammation with 10-year major adverse events (MACE) all-cause mortality in patients. Methods: A total 1858 participants from Atherosclerosis Risk Communities cohort study at visit 2 (1990– 1992) were included. 1338 non-MASLD also...
Three-dimensional (3D)-printed orthopedic surgical guides have the potential to provide personalized precision treatment. Non-isocyanate polyurethane (NIPU) is commonly used in 3D printing of biomedical materials but its application guide limited by poor mechanical properties and biocompatibility. In this study, we fabricated non-isocyanate acrylate (NIPUA) photosensitive resin with superior biocompatibility required for 3D-printed guides. NIPU prepolymer was synthesized a ring-opening...
312 Background: Currently, there are no standard perioperative regimens for human epidermal growth factor receptor 2 positive (HER2+) gastric cancer (GC) or gastroesophageal junction (GEJ) cancer. Furthermore, despite advances in neoadjuvant chemotherapy, the efficacy of treatment locally resectable advanced GC GEJ remains unsatisfactory. To address this need, we evaluated effectiveness adding atezolizumab (programmed death ligand-1 inhibitor) to with trastuzumab (a HER2 antibody) +...
Several circular RNAs (circRNAs) may have role important roles in biological processes, however, there is limited knowledge of circRNAs and their potential functions RAW264.7 macrophages. The present study aimed to examine the expression explore effects on interleukin‑6 (IL‑6) induced by calcitonin gene‑related peptide (CGRP) To identify circRNAs, circRNA was measured macrophages with or without CGRP stimulation. interaction between microRNAs (miRs) were then identified using bioinformatic...
Circular RNAs (circRNAs) are a class of non‑coding that exhibit important regulatory roles in various biological processes. However, the role circRNAs and their potential osteoblast differentiation mineralization is unclear. The aim present study was to investigate expression mmu_circ_003795 its effect on collagen type XV α 1 chain (COL15A1). First, it identified levels osteopontin (OPN) were upregulated induced cells. Silencing reduced gene protein COL15A1 OPN, whereas level mmu‑microRNA...
Anthrax represents a disease resulting from infection by toxin-secreting bacteria, Bacillus anthracis. This research aimed to identify new therapeutic targets combat anthrax. We performed assays assess cell viability, apoptosis, glycogen consumption, and compound uptake release in hepatocytes cardiomyocytes responding anthrax toxins. Microarray analysis was carried out the genes potentially involved toxin-induced toxicity. Knockdown experiments were validate contributions of identified...
Bordetella hinzii is a zoonotic pathogen, which can cause brain abscess, pneumonia, bacteremia, and urinary tract infection. Vaccines are economical effective means for combating infectious diseases. Herein, we present the first total synthesis of highly functionalized mono- oligosaccharides B. O-antigen vaccine development. The rare 2,3-diacetamidopyranoses were generated from 3-O-acetyl-2-nitroglycals via an organocatalyzed one-pot relay glycosylation method. postglycosylation oxidation...
Importance Effective treatment of locally advanced gastric cancer (GC) or gastroesophageal junction (GEJ) remains a challenge. Objective To compare the efficacy and safety atezolizumab plus trastuzumab capecitabine oxaliplatin chemotherapy (XELOX) vs XELOX in Chinese patients with human epidermal growth factor receptor 2 ( ERBB2 ; formerly HER2 )–positive GC adenocarcinoma GEJ. Design, Setting, Participants This was an open-label phase randomized clinical trial conducted at 8 study sites...
Accumulating evidence suggests that the epigenetic alterations caused by histone modifications have important roles in genesis of gastric cancer (GC), particularly well-studied acetylation and methylation modifications. In present study, a Bioinformatics analysis expression modification-associated genes GC normal tissues was performed using datasets from Oncomine, Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA). clinical data patients were downloaded TCGA to determine...
The objective was to construct a prognostic risk model of stomach adenocarcinoma (STAD) based on Cancer Proteome Atlas (TCPA) search for biomarkers. Protein data and clinical STAD were downloaded from the TCGA database, differential expressions proteins between carcinoma para-carcinoma tissues screened using R package. randomly divided into training set testing in 1:1 ratio. Subsequently, linear constructed Cox regression analysis data. Based scores model, sampled patients categorized two...
An abnormality in the regulation of adenosine deaminase acting on RNA (ADAR) enzymes, which catalyzed adenosine-to-inosine (A-to-I) editing, was closely associated with highly aggressive biologic behavior and poor prognosis many malignancies. In present study, we aimed to investigate relationship among transcript factors-microRNAs regulatory network, immune environment, ADAR gene colorectal carcinoma (CRC). The association expression levels mRNA copy number variation, methylation, mutation...