A5033663116- Microbial Inactivation Methods
- Toxin Mechanisms and Immunotoxins
- Cardiac electrophysiology and arrhythmias
- Plasma Applications and Diagnostics
- Ultrasound and Cavitation Phenomena
- Extraction and Separation Processes
- Nanoplatforms for cancer theranostics
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Cancer-related molecular mechanisms research
- Nicotinic Acetylcholine Receptors Study
- Clinical Laboratory Practices and Quality Control
- Geochemistry and Elemental Analysis
- Cardiac Arrhythmias and Treatments
- Digital Imaging for Blood Diseases
- Microfluidic and Bio-sensing Technologies
- Laser Applications in Dentistry and Medicine
- Cerebral Venous Sinus Thrombosis
- Electrostatic Discharge in Electronics
- Photodynamic Therapy Research Studies
- Neuroscience and Neural Engineering
- Advanced Neuroimaging Techniques and Applications
- Laser-induced spectroscopy and plasma
- MRI in cancer diagnosis
- Circular RNAs in diseases
Tianjin Medical University
2008-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011
Pulsed-field ablation (PFA) had potential advantages in atrial fibrillation ablation, and we aim to confirm the optimal parameter target of PFA for fibrillation. Two modes vitro single-cell system (ablation electrode cup) monolayer cell inserts with tips) were established perform myocardial H9C2 smooth muscle A7r5. Ablation effect, calcium ion influx, expression Cx45, surface morphological change observed. Three Bama minipigs used verify vivo effect PFA. In system, was significantly...
Time-dependent diffusion MRI (td-dMRI) has potential in characterizing microstructural features; however, its value imaging endometrioid endometrial adenocarcinoma (EEA) remains uncertain. Patients surgically confirmed with EEA were finally enrolled our study. The td-dMRI data acquired using pulsed gradient spin echo sequence and oscillating sequences. markers, including cell diameter, intracellular volume fraction (Vin), cellularity, extracellular diffusivity (Dex), fitted the parameters a...
Human immunodeficiency virus (HIV) particles that remain in the blood of patients are frequently ignored as targets for AIDS treatment. We therefore investigated use photodynamic therapy (PDT) with hematoporphyrin monomethyl ether (HMME) a means inactivating cell-free HIV vitro. Virus including HIV-1(IIIB), resistant HIV-1 variants, clinical and HIV-2 variants were incubated HMME 40 min, followed by irradiation 630-nm semiconductor laser at an energy density 0.3 J/cm(2). The antiviral...
The dielectric barrier discharge (DBD) plasma was applied to induce apoptosis of LT-12 leukemia cells. Plasma effects on cell death evaluated by MTT assay and FCM with Annexin V/PI double staining, suggesting that killing cells rate inducing both positively were related the doses or post-plasma time points. rates increased from 15.2% 33.1% raise 23.8% 28% when dose 60s 120 s at 8 h post-plasma, while they 15.4% 34.9% 48% 55.3% respectively same 12 post-plasma. Furthermore, production...
Irreversible electroporation (IRE) is a soft tissue ablation technique that uses short electrical fields which induce the death of target cells. To evaluate safety and efficacy an IRE-based device compared to regular radiofrequency (RFA) solid liver tumors, in this multicenter, randomized, parallel-arm, non-inferiority study, 152 patients with malignant tumors were randomized into IRE (n = 78) RFA 74) groups. The primary endpoint was success rate tumor ablation; secondary endpoints included...
Background The development of pulsed field ablation (PFA) as a new technique for pulmonary vein isolation (PVI) has been advancing rapidly in recent years. My team's previous work shown the safety and long-term efficacy bipolar asymmetric pulses animal experiments. However, ongoing clinical trials, we have observed that atrial fibrillation (AF) recurs some patients after surgery, but rhythm returns to normal without surgical intervention seven days, there is no recurrence follow-up.Based on...
Pulsed field ablation (PFA) is a novel method of pulmonary venous isolation in atrial fibrillation and featured by tissue-selective ablation. Isolation achieved via the application high-voltage microsecond pulses that create irreversible perforations cell membranes (i.e., electroporation). We proposed new biphasic asymmetric pulse mode verified lesion persistence safety this for vein ostia preclinical studies. found can effectively reduce muscle contractions drop threshold. In...
Pulsed field ablation (PFA) is a new treatment for atrial fibrillation (AF), and its selective characteristics give it significant advantage in treatment. In previous cellular animal experiments, we have demonstrated that biphasic asymmetric pulses can be used to ablate myocardial tissue. However, small-scale clinical trials are needed test whether this approach safe feasible before extensive performed. Therefore, the purpose of experiment determine safety feasibility patients with AF lay...
To evaluate the efficiency and safety of an optimized CO(2) Laser glaucoma surgery system for laser sclerectomy with iridectomy.Rabbit trials were performed to safety.IOP was significantly decreased in group compared trabeculectomy group(P<0.05) from 7(th) postoperative day 60(th) day. Compared group, histopathology studies confirmed fewer complications better effects found group.CO(2) iridectomy is effective safe terms IOP lowering.
Abstract New understanding of the pathogenesis atherosclerotic diseases has led to emergence new therapeutic approaches. We explored potential effects pulsed field ablation (PFA), a non-thermal technique with high tissue selectivity, on plaques. Carotid arteries 30 high-fat rabbits were dilated balloon obtain PFA was administered carotid plaques 1000V/cm, 2000V/cm, and 1000V/cm followed by rapamycin infusion. There no visible changes in blood vessels after acute ablation, but apoptosis...
Laser has been used in the treatment of glaucoma for more than twenty years.Its main applications include laser peripheral iridoplasty,laser trabeculoplasty,laser sclerostomy,and cyclophotocoagulation. Other such as C02 filtering surgery and photodynamic therapy(PDT)have just started.In this paper,a review is provided on present lasers including choice laser,indications,surgery approach efficacy.The prospect future application also discussed. Key words: Laser; Glaucoma; lifts
Objective To explore the killing effect of dielectric barrier discharge (DBD) plasma on tumor cells and to analyze DBD-induced apoptosis mechanism. Methods Thiazolyl blue tetrazolium bromide (MTT) assay method was used detect low temperature cytotoxicity normal spleen leukocytes acute promyelocytic leukemia (LT-12) at different doses. The changes reactive oxygen species (ROS) level were measured after treatment. cell rate detected by Annexin V/PI double staining expression...