A5114948811- Platelet Disorders and Treatments
- Blood groups and transfusion
- Monoclonal and Polyclonal Antibodies Research
- Renal Diseases and Glomerulopathies
- Mast cells and histamine
- Heparin-Induced Thrombocytopenia and Thrombosis
- Blood properties and coagulation
- Cell Adhesion Molecules Research
- Urticaria and Related Conditions
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Allergic Rhinitis and Sensitization
- Systemic Lupus Erythematosus Research
- Autoimmune Bullous Skin Diseases
- Probiotics and Fermented Foods
- Complement system in diseases
- Immune Cell Function and Interaction
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Biliary and Gastrointestinal Fistulas
- Cancer Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer Treatment and Pharmacology
- Metabolism and Genetic Disorders
- Gastrointestinal Tumor Research and Treatment
Chiba University
2007-2025
Tohoku University
1989-2025
Kasumigaura Medical Center
2017-2019
Saitama Medical University
1995-2017
JA Shizuoka Koseiren ENSHU hospital
2014
Obihiro Kosei General Hospital
2014
Murayama Medical Center
2013
Frontier Medical College
2012
Kitamurayama Hospital
2009-2012
Breast Center
2009
Mounting evidence has demonstrated that NOD-Shi/scid/γc(null) (NOG) mice are one of the most suitable mouse strains for humanized technologies, in which various human cells or tissues can be engrafted without rejection and autonomously maintained. We have characterized analyzed features immune system reconstituted NOG by transplanting hematopoietic stem (hu-HSC). One problems quasi-immune these hu-HSC is quality responses not always sufficient, as lack IgG production response to antigen...
The records of 45 patients with carcinoma the gallbladder who had undergone surgical resection at least 5 years previously were reviewed retrospectively to determine which factors influence long-term survival. Seventeen survived and 23 died from recurrence (five excluded analysis). Of 17 survivors 15 tumours superficial subserosa that showed a non-infiltrative growth pattern. Those alive more likely than short-term have papillary (P < 0.05) or well differentiated 0.01) adenocarcinoma....
Summary We investigated the association of amyloid β-protein precursor (APP) and platelet derived microparticles in 20 normal controls 91 patients with various diseases causing a thrombotic tendency. Compared controls, mean percentage APP-positive was significantly greater cerebral infarction (39.1 ± 17.7%, p <0.001), diabetes (31.1 12.6%, uremia (30.1 14.7%, <0.01), but not those hypertension (8.2 ±6.3%, = NS). Sixteen infarction, diabetes, 11 had very high APP levels. In 7.2 3.7%...
Abstract Glycoprotein (GP) IIb and IIIa are major constituents of the platelet membrane which involved in forming fibrinogen receptor on activated platelets. We used flow cytometry to study effects ethylene‐diamine tetraacetic acid (EDTA) GPIIb/IIIa complexes platelets microparticles, cations dissociated GP complexes. Microparticles were detected by both volume signal fluorescence using an FITC‐conjugated anti‐GPIb antibody (NNKY5–5). When stimulated with ADP, calcium ionophore A23187, or...
While histamine H4 receptor (H4R) has been implicated in immune system disturbances different organ tissues, the presence and possible roles of H4R synovial cells (SC) rheumatoid arthritis (RA) patients not previously documented. This study conclusively evidences expression SC RA by use RT-PCR method. As consists mainly immunological patients, this study's findings document a novel action site, opens potential new avenues to investigate mechanisms develop pharmacotherapeutic agents for disease.
Controlled laboratory study.This study aimed to evaluate the in vitro pharmacological activity of growth factors (GFs) freeze-dried platelet-rich plasma (FD-PRP) after storage for 4 weeks.Freshly prepared PRP is a rich source many GFs. We reported that FD-PRP stored 8 weeks accelerated bone union rat posterolateral fusion model equally well as fresh-PRP. However, longterm has not been shown vitro.Immediately preparation, storage, platelet count was measured. Human osteoblasts were treated...
Lacticaseibacillus rhamnosus CRL1505 and Lactiplantibacillus plantarum CRL1506 increase the resistance of mice to Gram-negative pathogens infections. In this work, we advanced characterization immunomodulatory properties by evaluating their effect on Toll-like receptor 4 (TLR4)-triggered immune response in macrophages. We performed experiments murine RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS) evaluate transcriptomic changes induced lactobacilli. These vitro were...
The last of four histamine receptors (HRs), H4 receptor (H4R), was identified in the year 2000. Since that time, H4R has been implicated cellular mechanisms related to immune systems, inflammatory processes, and allergic reactions. We have previously reported expression mRNA rheumatoid arthritic (RA) synovial cell cultures by means RT-PCR method. present study demonstrates at protein level RA cultures. also expressed two specific types populations, fibroblast-like macrophage-like cells from...
The purpose of this prospective cohort study was to clarify the safety and efficacy total hip arthroplasty via direct anterior approach in supine position with a novel mobile traction table. first experience consecutive surgeries by single surgeon using table is described two-year follow-up period. Of 121 patients, 100 patients without previous surgeries, severe deformity, or cemented implants were divided into two groups comprising 50 second patients. implant survival rate 99% at follow-up....
To study the outcomes and experiences of using metallic stents in treating patients with malignant ureteral obstruction (MUO), we examined effects stenting Cook Resonance® stent treatment MUO.All who had a Resonance inserted between April 2015 March 2018 at one multiple facilities were prospectively observed 1-year follow-up. The primary outcome was patency rate stent. secondary included complications (e.g., infection fever).Although insertion attempted 50 patients, could not be as three due...
We investigated the characteristics of antiplatelet autoantibodies in 60 patients with ITP. Using flow cytometry, binding monoclonal antibodies to platelet glycoprotein (GP) IIb/IIIa complex and GPIb was examined these patients. The extent decreased 15 (anti‐GPIIb/IIIa 12 both anti‐GPIIb/IIIa anti‐GPIb 3 patients). Western blotting revealed that 10 had either anti‐GPIIb or anti‐GPIIIa 2 autoantibodies. ADP‐induced aggregation normal platelets inhibited by patients, 11 antibodies....
Abstract IEF, using 6 M urea, provides a unique opportunity to analyze the spectrotypes of antibodies in immune complexes (IC) vivo. Using this technique, we have analyzed clonotypes anti-DNA expressing specific Id circulating IC patients with active lupus nephritis. Serum anti-ssDNA and anti-dsDNA showed heterogeneous spectrotypes. The isolated from had restricted clonotype neutral charge were directed mainly ssDNA and, lesser extent, dsDNA. These samples failed form DNA when they subjected...
Summary. In a patient with immune thrombocytopenic purpura (ITP), we found novel platelet‐activating IgG (act‐IgG) and an inhibitory (inhi‐IgG) that prevented activation induced by both CD9 monoclonal antibody (mAb) the act‐IgG. Purified from plasma caused rise in [Ca 2+ ] i aggregation of normal platelets, bound to 24 kD membrane protein. This was inhibited aspirin, staurosporine, inhibitor protein kinase C, F(ab′) 2 fragments MALL13, mAb. When platelet count this rose range, act‐IgG...
Histologic localizations of terminal complement complexes (TCCs) were examined and compared with clinical findings in 154 patients various renal diseases. Immunohistochemical demonstration TCCs was carried out on ethanol-fixed paraffin-embedded biopsy specimens by indirect immunoperoxidase technique. In glomerular diseases that are thought to be immune-complex glomerulonephritis (IC-GN), such as IgA-nephropathy, membranous nephropathy, systemic lupus erythematosus (SLE), demonstrated a...