A5079555852- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- HIV-related health complications and treatments
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- HIV, Drug Use, Sexual Risk
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Diabetes and associated disorders
- Asthma and respiratory diseases
- Liver Disease and Transplantation
- Orthopedic Infections and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Artificial Intelligence in Healthcare
- Surgical site infection prevention
- Immunodeficiency and Autoimmune Disorders
- IoT and Edge/Fog Computing
- Drug-Induced Adverse Reactions
- Immune Response and Inflammation
Universidad de Alcalá
2009-2025
Hospital Universitario Príncipe de Asturias
2015-2024
Instituto Ramón y Cajal de Investigación Sanitaria
2020-2023
Instituto de Salud Carlos III
2022-2023
Centro de Investigación Biomédica en Red
2022
Hospital Clínico San Carlos
2022
Universidad Complutense de Madrid
2022
Hospital Casa de Salud
2021
Hospital de Sant Pau
2021
Hospital Universitario Ramón y Cajal
2018-2020
Human immunodeficiency virus (HIV) infection modifies the natural history of chronic hepatitis C, thus promoting more rapid progression to cirrhosis and end-stage liver disease. The objective our study was determine whether C (HCV) clearance is associated with improved clinical outcomes in patients positive for HIV HCV. It an ambispective cohort carried out 11 units Spain involved 711 consecutive HIV/HCV who started interferon plus ribavirin therapy between 2000 2005. We measured sustained...
Background. Sustained virological response (SVR) after therapy with interferon plus ribavirin reduces liver-related complications and mortality in patients coinfected human immunodeficiency virus (HIV) hepatitis C (HCV). We assessed the effect of SVR on HIV progression not related to liver disease.
The magnitude of sexualized drug use (SDU), also known as chemsex, and its association with sexually transmitted infections (STI) has not been systematically explored in HIV-positive patients. This study aimed to calculate the prevalence SDU associated factors a sample men who have sex (MSM) Spain. We calculated frequency MSM responded an anonymous online survey on sexual behavior recreational use. analyzed differences between those did (data taken from physician's registry). SDU, risk...
We analyzed the incidence of lower extremity amputations (LEAs) in 3rd Health Care Area Madrid before and after March 2008 introduction a multidisciplinary team for managing diabetic foot disease. compared amputation rates people with without diabetes during 2 periods: (2001-2007) (2008-2011) Multidisciplinary Diabetic Foot Unit (MDFU). also trend by joinpoint regression analysis measured annual percentage change (APC). During study period, 514 nontraumatic LEAs were performed, 374 (73%) 140...
Our objective was to assess the therapeutic noninferiority of dual therapy with darunavir/ritonavir and lamivudine compared triple plus 2 nucleos(t)ides for maintenance human immunodeficiency virus type 1 (HIV-1) suppression.This a multicenter, open-label, trial (margin 12%). Patients HIV-1 RNA <50 copies/mL 6 months or longer on (tenofovir disoproxil fumarate emtricitabine abacavir lamivudine) no resistance were randomized continue (n = 128) switch 129). The primary endpoint proportion...
Abstract Evidence shows that engaging in sexualized drug use (SDU) can be associated with sexual health problems and poor mental health. However, the prevalence of drug-related SDU remains unclear. Our study aimed to examine factors dependence a sample gay, bisexual, other men who have sex living HIV (HIV + GBMSM). We included 101 GBMSM had engaged last year. Participants completed an online survey featuring validated questionnaire (the DUDIT test) assess risk dependence. Univariate...
To assess lipoatrophy, other toxicities, and efficacy associated with abacavir as compared stavudine in HIV-infected antiretroviral-naive patients.This was a prospective, randomized, open trial, stratified by viral load CD4 cell count, conducted January 2001 to July 2004. Two hundred thirty-seven adult patients HIV infection initiating antiretroviral therapy were assigned receive (n = 115) or 122), both combined lamivudine efavirenz. The primary endpoint the proportion of lipoatrophy...
Introduction: The optimal timing for initiation of highly active antiretroviral therapy (HAART) in patients with AIDS and tuberculosis (TB) is an unresolved question. To assess the effect HAART on survival TB, we designed this study. Methods: We selected all HIV included COMESEM cohort TB diagnosis after 1996. Clinical epidemiological data were registered. compared who started at [simultaneous (ST)] or not. Survival was assessed by Cox analysis. Results: Among 6934 cohort, 1217 had 322 them...
We evaluated treatment outcomes in a prospective registry of human immunodeficiency virus/hepatitis C virus (HCV)–coinfected patients treated with interferon‐free direct‐acting antiviral agent–based therapy hospitals from the region Madrid between November 2014 and August 2016. assessed sustained viral response at 12 weeks after completion used multivariable logistic regression to identify predictors failure. 2,369 patients, whom 59.5% did not have cirrhosis, 33.9% had compensated 6.6%...
We evaluated whether maintenance therapy with atazanavir/ritonavir plus lamivudine (ATV/r + 3TC) was non-inferior to ATV/r two nucleosides 2NUCs) at 96 weeks of follow-up.SALT is a multicentre, open-label, non-inferiority clinical trial in HIV-1-infected virologically suppressed patients. Hepatitis B virus surface antigen-negative subjects no previous treatment failure/resistance mutations and HIV-1-RNA <50 copies/mL for ≥6 months were randomized (1 : 1) 3TC or 2NUCs. The primary endpoint...
Main cause of severe illness and death in COVID-19 patients appears to be an excessive but ineffectual inflammatory immune response that may acute respiratory distress syndrome (ARDS). Vitamin D favour anti-inflammatory environment improve cytotoxic against some infectious diseases. A multicenter, single-blind, prospective, randomized clinical trial was approved with pneumonia levels 25-hydroxyvitamin (25(OH)D) 14.8 ng/ml (SD: 6.18) test antiviral efficacy, tolerance safety 10,000 IU/day...
Data comparing abacavir/lamivudine versus tenofovir/emtricitabine in antiretroviral-naive patients are controversial. We compared 48-week efficacy and safety of these combinations as substitutes nucleosides with virological suppression.We randomly assigned 333 HIV-1-infected on lamivudine-containing triple regimens <200 copies per milliliter for at least 6 months to switch their either (n = 167) or 166). The primary outcome was treatment failure ["switching failure" intention treat (ITT)...
We assessed non-liver-related non-acquired immunodeficiency syndrome (AIDS)-related (NLR-NAR) events and mortality in a cohort of human virus (HIV)/hepatitis C (HCV)-coinfected patients treated with interferon (IFN) ribavirin (RBV), between 2000 2008. The censoring date was May 31, 2014. Cox regression analysis performed to assess the adjusted hazard rate (HR) overall death responders nonresponders. Fine Gray conducted determine subhazard (sHR) NLR deaths NLR-NAR considering as competing...
Objectives Sexualized intravenous drug use, also known as slamsex, seems to be increasing among HIV-positive men who have sex with (MSM). Physical and psychopathological symptoms previously been reported in this population, although research on the subject of slamsex is scarce. The objectives our study were describe background a sample MSM engaged during previous year compare physical, psychopathological, drug-related between these participants those non-injecting sexualized use. Design...
SARS-CoV-2 is a new coronavirus characterized by high infection and transmission capacity. A significant number of patients develop inadequate immune responses that produce massive releases cytokines compromise their survival. Soluble factors are clinically pathologically relevant in COVID-19 survival but remain only partially characterized. The objective this work was to simultaneously study 62 circulating soluble factors, including innate adaptive receptors, chemokines growth...
Objectives: Immune dysregulation is a hallmark of HIV and hepatitis C virus (HCV) infections. We aimed to evaluate the relationship between liver stiffness measurement (LSM) biomarkers T-cell activation, bacterial translocation, inflammation, endothelial dysfunction, coagulopathy in HIV/HCV-coinfected patients. Design: Cross-sectional study. Methods: studied 238 patients, 32 healthy controls, 39 HIV-monoinfected Patients were stratified according LSM into four groups: less than 12.5,...
Abstract Objectives We assessed the prevalence of anti‐hepatitis C virus (HCV) antibodies and active HCV infection (HCV‐RNA‐positive) in people living with HIV (PLWH) Spain 2019 compared results those four similar studies performed during 2015–2018. Methods The study was 41 centres. Sample size estimated for an accuracy 1%. Patients were selected by random sampling proportional allocation. Results reference population comprised 973 PLWH, sample 1325. serostatus known 1316 PLWH (99.3%), whom...
Background. The purpose of this study was to assess the prevalence anti-hepatitis C virus (HCV) antibodies (Abs) and active HCV infection in human immunodeficiency (HIV)-infected (HIV+) patients Spain 2015. This a cross-sectional study. Methods. performed 41 centers Sample size estimated for an accuracy 2%, number from each hospital determined by proportional allocation, were selected using simple random sampling. Results. reference population 35 791 patients, sample 1867 patients. Hepatitis...
Background. We compared the prognostic value of liver biopsy (LB) and FIB-4 index in patients with human immunodeficiency virus (HIV)/hepatitis C (HCV) coinfection.
This article describes the design, development and implementation of a set microservices based on an architecture that enables detection assisted clinical diagnosis within field infectious diseases elderly patients, via telemonitoring system. The proposed system is designed to continuously update medical database fed with vital signs from biosensor kits applied by nurses people daily basis. hosted in cloud managed flexible software architecture. computational paradigms edge were used hybrid...