Summary Background and objectives Relatively little is known about the long-term outcomes of different histologic types primary glomerulonephritis in Asian populations. Design, setting, participants, & measurements From 1993 to 2006, 987 patients undergoing renal biopsy were studied, 580 (mean age=44.4 years, male=58.5%) with four most common forms (membranous nephropathy, focal segmental glomerulosclerosis, IgA minimal change disease) selected for analysis. Median follow-up period was...

Background Learning self-efficacy, defined as learners' confidence in their capability to learn specific subjects, is crucial for the enhancement of academic progress, because it positively correlated with achievements and effective learning strategy use. In this study, we developed a universal scale called Self-Efficacy Scale (L-SES) Clinical Skills undergraduate medical students validated through item analysis content validity index (CVI) calculation. Design The L-SES was based on...

Biomarkers of chronic kidney disease-mineral and bone disorder (CKD-MBD) correlate with morbidity mortality in dialysis patients. However, the comparative roles each CKD-MBD biomarker remained undetermined on long-term peritoneal (PD) This retrospective study, employing a population-based database, aimed to evaluate performance provide best evidence as predictor all-cause mortality. Throughout 8-year study period, total 12,116 PD patients were included this study. Cox proportional regression...

Continuous renal replacement therapy (CRRT) is one of the dialysis modalities for critically ill patients. Despite intensive care, a high mortality rate found in these Our objective was to investigate factors associated with poor outcomes We conducted retrospective cohort study using National Health Insurance Research Database. Records patients who received CRRT between 2007 and 2011 were retrieved, categorized into two groups: those acute kidney injury (AKI) history end-stage disease...

In hemodialysis patients, arrhythmias are a significant concern due to mineral bone disease, despite efforts address abnormalities in plasma calcium and phosphorus levels. Metastatic calcification, the abnormal accumulation of soft tissues, is common consequence these metabolic disorders can contribute development cardiac conduction issues. This case report as it emphasizes serious cardiovascular risks associated with metastatic calcification particularly its role developing such...

Background Metformin use reduces the incidence and severity of stroke in patients with type 2 diabetes mellitus ( DM ). The benefits metformin for have not been examined hemodialysis . Methods Results Using National Health Insurance Research Database, we identified 17 760 new‐onset between 2001 2013. Of these, 1898 hospitalized either ischemic or hemorrhagic were matched to 7592 control according sex, age, year initial therapy by using sampling. association risk was estimated conditional...

Patients with white coat hypertension comprise a substantial portion of the hypertensive population. Previous reports have shown that moderate-intensity regular exercise training in patients mild usually reduces blood pressure (BP), but there is lack data regarding individuals hypertension. This study was performed to evaluate whether programmed effective reducing BP and it also had beneficial effects on other biochemical parameters. A total 42 (23 men 19 women) (mean 24-h ambulatory 119.2 ±...

Antibody glycosylation plays a crucial role in the humoral immune response by regulating effector functions and influencing binding affinity to cell receptors. Previous studies have focused mainly on immunoglobulin G (IgG) isotype owing analytical challenges associated with other isotypes. Thus, development of sensitive accurate platform is necessary characterize antibody across multiple In this study, we developed an workflow using antibody-light-chain beads purify IgG, IgA, IgM from 16 μL...

Predicting mortality in dialysis patients based on low intact parathyroid hormone levels is difficult, because aluminum intoxication, malnutrition, older age, race, diabetes, or peritoneal may influence these levels. We investigated the clinical implications of relation to using sensitive, stratified, and adjusted models a nationwide database. analyzed data from 2005 2012 that were held Taiwan Renal Registry Data System, 94,983 hemodialysis with valid regarding their included this study. The...

Previous studies show that serum bilirubin has potent antioxidant effect and is associated with protection from kidney damage reduce cardiovascular events. The aim of this study was to examine the association total level mortality in uremia patients who underwent hemodialysis.This a nationwide retrospective long-term cohort study. Patients were registered Taiwan Renal Registry Data System (TWRDS) 2005 2012. A 115,535 hemodialysis surveyed those valid baseline (TB) data enrolled. All-cause...

The effectiveness and safety of direct-acting antiviral agents (DAAs) in hepatitis C virus (HCV) patients with renal insufficiency remain controversial. Therefore, this network meta-analysis aims to assess DAAs populations different function. pooled data were obtained from Cochrane Library, EMBASE, PubMed, Web Science. Thirteen studies recruited 6884 infection reported their outcomes relation levels function after treatment DAAs. results showed no difference the virologic responses among...

The estimated prevalence of xerostomia (lack saliva) ranges from 10% to 50% the general population. oral cavity provides a multivariant environmental habitat over 700 species bacteria and fungi. We hypothesized that will alter composition microbiota. Nineteen patients 10 healthy normal volunteers were studied for Gingival plaques collected microbiota detected using bacterial 16S ribosomal RNA analyzed based on levels phylum class. In all cases, phyla Actinobacteria, Bacteroidetes,...

The effects of various cardiovascular diseases on the risk venous thromboembolism (VTE) are not well defined. To gather more information, we performed a hospital-based case-control study to evaluate major VTE.We identified all incident cases VTE needing hospitalization and anticoagulant therapy between January 1990 December 2002 in large tertiary hospital. Each case was matched with up 4 controls, randomly selected from inpatients who were hospitalized due any exposures, age, sex, calendar...

Anemia is common among end-stage renal disease (ESRD) patients who undergone hemodialysis. The total reduction of red blood cell (RBC) count associated with poor prognosis in these patients. Although erythropoietin (EPO) has been used as an effective treatment for ESRD anemia, a large number still present responses to EPO treatment. We measured T-cell receptor sequencing profiles, including length complementarity-deteremining region 3 (CDR3), intra- and inter-group (EPO resistant vs....

Objectives In Taiwan, peritoneal dialysis (PD) and haemodialysis are fully accessible to patients with end-stage renal disease. However, the usage of PD is considered low in Taiwan. Since 2005, 4 major policies have been implemented by Taiwan's Ministry Health Welfare, namely a multidisciplinary predialysis care programme increasing incidence as key performance indicator (KPI) for hospital accreditation, both which were 2006; reimbursement glucose-free dialysate, icodextrin that was 2007;...

Although α-glucosidase inhibitors (AGIs) are commonly used for controlling postprandial blood glucose, AGIs-induced liver injuries have been reported. However, the relationship between AGIs and in advanced chronic kidney disease (CKD) patients remains unexplored. In this nationwide case-control study, we recruited 1765 diabetic CKD patients, who received therapy from January 1, 2000 to December 31, 2010 as study sample 5295 matched controls. Recent former users were defined prescription...

Chronic kidney disease (CKD) patients tend to have a reduced immune response infection and vaccination. The efficacy of current available COVID-19 vaccines in CKD has not been widely evaluated.In the present study, three hundred eight chronic dialysis received ChAdOx1 nCoV-19 (Oxford-AstraZeneca, AZ). Blood tests using an antibody against receptor-binding domain (RBD) S1 subunit SARS-CoV-2 spike protein had performed at four designed time points before after first second vaccine.The mean age...

Introduction: End-stage kidney disease (ESKD) patients who need renal replacement therapy to face a dialysis modality decision: the choice between hemodialysis (HD) and peritoneal (PD). Although global differences in HD/PD penetration are affected by health-care policies, these two modalities may exert different effects on survival with ESKD. Taiwan did not implicate PD as first policy, we still compare patients’ outcomes using nation-wise database determine future care health policies....