A5102800931- Renal Transplantation Outcomes and Treatments
- Retinal and Macular Surgery
- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
- COVID-19 and healthcare impacts
- Gastrointestinal disorders and treatments
- Renal Diseases and Glomerulopathies
- Pain Management and Placebo Effect
- Cardiac, Anesthesia and Surgical Outcomes
- Head and Neck Surgical Oncology
- Enhanced Recovery After Surgery
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Oral and Maxillofacial Pathology
- Pancreatitis Pathology and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Cancer survivorship and care
- Colorectal Cancer Surgical Treatments
- Organ Donation and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hernia repair and management
- Medical Practices and Rehabilitation
- Cancer, Hypoxia, and Metabolism
- Corneal Surgery and Treatments
- Cancer Genomics and Diagnostics
University Hospital Augsburg
2016-2025
University of Augsburg
2022-2024
May Institute
2024
Saitama Medical University
2022
Universität Ulm
2012-2020
Universitäts-HNO-Klinik Heidelberg
2012-2019
Institute for Transfusion Medicine
2019
Boehringer Ingelheim (Germany)
2015
University of Regensburg
2007-2008
University of Münster
2007
Recently, our group introduced Stroma AReactive Invasion Front Areas (SARIFA) as an independent prognostic predictor for a poorer outcome in colon cancer patients, which is probably based on immunologic alterations combined with direct tumor-adipocyte interaction: the two together reflecting distinct tumor biology. Considering it already known that peripheral immune cells are altered colorectal (CRC) this study aims to investigate changes lymphocyte subsets SARIFA-positive cases and...
Chemotherapy is established as primary treatment in patients with stage IV colorectal cancer and unresectable metastases. Data from nonrandomized clinical trials have fueled persistent uncertainty if tumor resection (PTR) before chemotherapy prolongs survival. We investigated the prognostic value of PTR newly diagnosed colon who were not amenable to curative treatment.
Abstract Background Pylorus-preserving partial pancreatoduodenectomy (ppPD) is a treatment for tumors of the pancreatic head. Delayed gastric emptying (DGE) one most common complications following ppPD. In retrospective analysis, intraoperative endoluminal pyloromyotomy (PM) was shown to be associated with reduction in DGE rates. Objective The aim this randomized controlled trial investigate effect PM on after Methods Patients undergoing ppPD were intraoperatively receive either or...
The prognostic value of preformed donor-specific HLA antibodies (DSA), which are only detectable by sensitive methods, remains controversial for kidney transplantation.The outcome 4233 consecutive transplants performed between 2012 and 2015 in 18 German transplant centers was evaluated. Most used a stepwise pretransplant antibody screening with bead array tests differentiation positive samples single antigen assays. Using these results, DSA against HLA-A, -B, -C, -DRB1 -DQB1 were determined....
Chronic pruritus is a symptom of many diseases, with studies pending investigating its prevalence or incidence. The aim this study was to describe the characteristics underlying diseases in large number patients. A total 263 patients (110 men, 153 women; age range 8-95 years; mean 55.9 years) were included study. following data collected from presenting over 3-year period: gender, age, history, skin lesions, laboratory, histological and radiological investigations. An dermatosis identified...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a ‘difficult-to-treat’ entity. To forecast its prognosis, we introduced new biomarker, SARIFA (stroma areactive invasion front areas), which are areas at the tumour lacking desmoplastic stroma reaction upon malignant in surrounding tissue, leading to direct contact between cells and adipocytes. showed significance gastric colorectal carcinoma, revealing lipid metabolism alternations that promote progression. Methods We reviewed...
Abstract A cancer diagnosis and subsequent treatment can trigger distress, negatively impact coping resources, affect well-being as well quality of life. The aim this pilot study was to investigate feasibility clinical effects a VR intervention on life, mood in patients undergoing surgery compared non-VR control group. 54 with colorectal or liver metastases from elective curatively intended were recruited randomised one two groups group receiving standard treatment. Participants assigned the...
Introduction: Early mobilization after surgery is crucial for reducing postoperative complications and restoring patients' fitness ability to care themselves. Immersive, activity-promoting games in virtual reality (VR) can be used as a low-cost motivational adjunct standard physiotherapy promote recovery surgery. In addition, they have potentially positive effects on mood well-being, which are often compromised colorectal The purpose of this pilot study was evaluate the feasibility clinical...
Colectomy is the surgical treatment of choice in patients with severe or complicated ulcerative colitis. Post-colectomy enteritis (PCE) a rare condition that can develop after proctocolectomy and has been described only few individual cases so far. We report case 46-year-old patient treatment-refractory colitis who underwent colectomy. A days surgery, presented acute anemia hematemesis. Esophagogastroduodenoscopy showed massive inflammation duodenum jejunum. The life-threateningly ill was...
Background: mTOR-Is positively influence the occurrence and course of certain tumors after solid organ transplantation. mTOR-inhibitor (mTOR-I) treatment, either alone or in combination with Calcineurininhibitors (CNIs), significantly reduces incidence malignancies However, there is no information on which mTOR-I, Sirolimus (SIR) Everolimus (ERL), has a stronger anti-tumoral effect. Methods: The current literature was searched for prospective randomized controlled trials renal There were...
Cellular immune response to cancer is known be of great importance for tumor control. Moreover, solid tumors influence circulating lymphocytes, which has been shown several types cancer. In our prospective study we elucidate changes in lymphocyte subsets patients with colorectal carcinoma compared healthy volunteers.Flow cytometry was performed at diagnosis colon analyze B cells, T cells and NK including various subtypes each group. Univariate multivariate analyses age, gender, stage,...
Abstract Background High-level evidence regarding the technique of abdominal wall closure for patients undergoing emergency midline laparotomy is sparse. Therefore, we conducted a randomized controlled trial (RCT) to evaluate efficacy and safety two commonly applied strategies after primary laparotomy. Methods/design CONTINT was multi-center pragmatic open-label exploratory parallel trial. Two different in an surgical intervention with suspected septic focus cavity were compared: continuous,...
Background. Preformed donor-specific HLA antibodies (DSA) are a well-known risk factor in kidney transplantation. There is still considerable debate, however, about the optimal stratification among patients with preformed DSA. Additionally, data on prognostic value of different crossmatch assays DSA-positive scarce. Methods. living transplant recipients were selected from multicenter study examining 4233 consecutive renal transplants. An additional 7 2 further centers included. Flow...
Currently, pathological evaluation of stage I/II colon cancer, following the Union Internationale Contre Le Cancer (UICC) guidelines, is insufficient to identify patients that would benefit from adjuvant treatment. In our study, we analyzed tissue samples 276 with cancer utilizing mass spectrometry imaging. Two distinct approaches are herein presented for data processing and analysis. one approach, four different machine learning algorithms were applied predict tendency develop metastasis,...
The assignment of human leucocyte antigens (HLAs) against which antibodies are detected as unacceptable (UAGs) avoids allocation HLA- incompatible allografts. There is uncertainty to what extent UAGs decrease the probability receiving a kidney offer.Kidney transplantations in 3264 patients on waiting lists six German transplant centres were evaluated for period at least 2 years. proportion excluded offers due was calculated virtual panel-reactive (vPRAs).In common Eurotransplant Kidney...
BackgroundIn the Eurotransplant Kidney Allocation System (ETKAS), transplant candidates can be considered for high-urgency (HU) status in case of life-threatening inability to undergo renal replacement therapy. Data on outcomes HU transplantation are sparse and benefit is controversial.
(1) Background: Following renal transplantation, infection with cytomegalovirus (CMV) is a common and feared complication. mTOR-inhibitor (mTOR-I) treatment, either alone or in combination calcineurininhibitors (CNIs), significantly reduces the CMV incidence after organ transplantation. As of now, there no information on which mTOR-I, sirolimus (SIR) everolimus (ERL), has stronger anti-CMV effect. (2) Methods: The current literature was searched for prospective randomized controlled trials...
Abstract Background Physical inactivity after surgery is an important risk factor for postoperative complications. Compared to conventional physiotherapy, activity-promoting video games are often more motivating and engaging patients with physical impairments. This effect could be enhanced by immersive virtual reality (VR) applications that visually, aurally haptically simulate a environment provide interactive experience. The use of VR-based fitness in the early phase contribute improved...
A prerequisite to successfully engineer cell-based adipose tissue surrogates is the evaluation of in vitro culture conditions that facilitate expansion primary precursor cells under retention their adipogenic potential and enable a large fraction heterogeneous cell pool undergo adipogenesis upon respective stimuli. Ascorbic acid (AA) was reported enhance differentiation into various mesenchymal types. Thus, aim current study evaluate influence AA on hormonally induced bone marrow-derived...
The coronavirus disease 2019 (COVID-19) pandemic is an ongoing severe issue.The aim of this study was to compare the incidence, severity and treatment acute appendicitis (AA) before during COVID-19 pandemic.A retrospective cohort analysis conducted between January April 2020 in one high-volume center. A comparison performed two groups (Group A: patients admitted with AA pandemic; Group B: at beginning pandemic) terms incidence clinical pathological outcomes. also analyzed six surrounding...
Abstract Background: As patient stratification still needs to be refined in colorectal cancer (CRC), we established SARIFA (Stroma AReactive Invasion Front Areas) as a novel H&E-based prognostic biomarker that is defined by direct tumor-adipocyte interaction with lack of desmoplastic reaction. Even though could prove the high relevance now multiple cohorts gastric, colorectal, and pancreatic cancer, well link an upregulation lipid metabolism immune alterations this specific aggressive...
Background/Objectives: Locally advanced rectal cancer is treated with neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision (TME). As this approach achieves complete pathologic remissions (pCR) in approximately 30% of patients, it raises the question whether surgery always necessary. Non-surgical strategies, such as “watch and wait” (W&W), have shown similarly promising outcomes. However, there an unmet need for reliable biomarkers predicting pCR. Analysis...