A5101943180- Zebrafish Biomedical Research Applications
- Autophagy in Disease and Therapy
- Hydrogels: synthesis, properties, applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Erythrocyte Function and Pathophysiology
- Cancer-related gene regulation
- Cardiac Ischemia and Reperfusion
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Electrospun Nanofibers in Biomedical Applications
- Fungal Biology and Applications
- RNA modifications and cancer
- 3D Printing in Biomedical Research
- Fungal and yeast genetics research
- Pain Mechanisms and Treatments
- Immune Cell Function and Interaction
- Cardiovascular Function and Risk Factors
- Epigenetics and DNA Methylation
- Cellular transport and secretion
- Hemoglobinopathies and Related Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Drug Solubulity and Delivery Systems
- Lipid Membrane Structure and Behavior
- Peripheral Neuropathies and Disorders
Yantai University
2023-2025
Chongqing Medical University
2022-2024
Shanghai Institute of Nutrition and Health
2021-2024
Chinese Academy of Sciences
2013-2021
Yale University
2017-2021
Shanghai Jiao Tong University
2010-2018
Shanghai Institutes for Biological Sciences
2010-2018
Guizhou University
2018
Guizhou Academy of Agricultural Sciences
2017-2018
Ruijin Hospital
2010
Background: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common disease characterized by persistent hypoxemia and an uncontrolled inflammatory response. Valsartan, angiotensin II type 1 receptor antagonist, clinically used to treat hypertension has anti-inflammatory antioxidant effects on gefitinib-induced pneumonia in rats. However, the potential therapeutic of valsartan lipopolysaccharide (LPS)-induced ALI remain unclear. This study investigated protective role...
Dysregulation of ribosome biogenesis causes human diseases, such as Diamond-Blackfan anemia, del (5q-) syndrome and bone marrow failure. However, the mechanisms blood disorders in these diseases remain elusive. Through genetic mapping, molecular cloning mechanism characterization zebrafish mutant cas002, we reveal a novel connection between ribosomal dysfunction excessive autophagy regulation hematopoietic stem/progenitor cells (HSPCs). cas002 carries recessive lethal mutation kri1l gene...
<h2>Summary</h2> Polarized vesicle transport plays an important role in cell polarization, but the mechanisms underlying this process and its innate immune responses are not well understood. Here, we describe a phosphorylation-regulated polarization mechanism that is for neutrophil adhesion to endothelial cells during inflammatory responses. We show protein kinase PKN1 phosphorylates RPH3A, which enhances binding of RPH3A guanosine triphosphate (GTP)-bound RAB21. These interactions polarized...
Loss of the tumor suppressor phosphatase and tensin homolog (PTEN) is frequently observed in hematopoietic malignancies. Although PTEN has been implicated maintaining quiescence stem cells (HSCs), its role hematopoiesis during ontogeny remains largely unexplored. The expression marker genes was analyzed via whole mount situ hybridization assay ptena ptenb double mutant zebrafish. embryonic myelopoiesis characterized by living imaging immunofluorescence with confocal microscopy, as well...
LWJ-M30 targeted TfR, dramatically decreased the level of polymeric tubulin, while disruption microtubules meant cell cycle was arrested in G2/M phase and thus caused cells apoptosis.
Cell polarization is a key step for leukocytes adhesion and transmigration during leukocytes' inflammatory infiltration. Polarized localization of plasma membrane (PM) phosphatidylinositol-4-phosphate (PtdIns4P) directs the RPH3A, which contains PtdIns4P binding site. Consequently, RPH3A mediates RAB21 PIP5K1C90 polarization, important neutrophil to endothelia inflammation. However, mechanism by recruited only PM rather than Golgi remains unclear. By using ADP-ribosylation factor 6 (ARF6)...
The aberrant activation of Ras signaling is associated with human diseases including hematological malignancies and vascular disorders. So far the pathological roles activated in hematopoiesis vasculogenesis are largely unknown. A conditional Cre/loxP transgenic strategy was used to mediate specific expression a constitutively active form N-Ras zebrafish endothelial hematopoietic cells driven by lmo2 promoter. marker genes analyzed both via whole mount situ hybridization (WISH) assay...
MAP3K inhibition attenuates acute lung injuries in mice and reduced edema transplantation recipients.
Abstract Coat protein complex I (COPI) vesicles mediate the retrograde transfer of cargo between Golgi cisternae and from to endoplasmic reticulum (ER). However, their roles in cell cycle proliferation are unclear. This study shows that TANGO6 associates with COPI via two transmembrane domains. The N- C-terminal cytoplasmic fragments capture RNA polymerase II subunit B (RPB) 2 cis -Golgi during G1 phase. COPI-docked carries RPB2 ER then nucleus. Functional disruption hinders nuclear entry...
Fate determination and expansion of Hematopoietic Stem Progenitor Cells (HSPCs) is tightly regulated on both transcriptional post-transcriptional level. Although regulation HSPCs have achieved a lot advances, its remains largely underexplored. The small size high fecundity zebrafish makes it extraordinarily suitable to explore novel genes playing key roles in definitive hematopoiesis by large-scale forward genetics screening. Here, we reported mutant line
Vertebrate erythropoiesis involves nuclear and chromatin condensation at the early stages of terminal differentiation, which is a unique process to distinguish mature erythrocytes from erythroblasts. However, underlying mechanisms during erythrocyte maturation remain elusive. Here, we reported novel zebrafish mutant cas 7 with erythroid deficiency. Positional cloning showed that single base mutation in tprb gene, encodes nucleoporin translocated promoter region (Tpr), responsible for...
Aspergillus cristatus develops into various stages under different Na concentrations: the sexual stage in 0.5 M NaCl and asexual development 3 NaCl. In order to explore whether Ca 2+ signaling pathway A. responded changes salt stress, we analyzed gene expression levels respectively cultured According BLAST analysis results, identified 25 ‐signaling proteins . The of most genes involved concentrations showed significant differences, indicating that was response stress. yeasts, only calcium...
Purpose. Myocardial ischemia-reperfusion (MIR) injury is a common stimulus for cardiac diseases like arrhythmias and heart failure may cause high mortality rates. Salviae miltiorrhizae liguspyragine hydrochloride glucose injection (SGI) has been widely used to treat myocardial cerebral infarctions in China even though its pharmacological mechanisms are not completely clear. Methods. The protective effect mechanism of SGI on MIR were investigated through the H9c2 cell model induced by...