A5103199712- Circular RNAs in diseases
- Sexual function and dysfunction studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Plant Virus Research Studies
- MicroRNA in disease regulation
- Fungal Plant Pathogen Control
- Quinazolinone synthesis and applications
- Hormonal and reproductive studies
- Advanced Glycation End Products research
- Microbial metabolism and enzyme function
- Regulation of Appetite and Obesity
- Calpain Protease Function and Regulation
- Cancer, Lipids, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Tea Polyphenols and Effects
- Peptidase Inhibition and Analysis
- Receptor Mechanisms and Signaling
- Anesthesia and Neurotoxicity Research
- Heat shock proteins research
- RNA Research and Splicing
- Adipokines, Inflammation, and Metabolic Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pain Mechanisms and Treatments
Baoding People's Hospital
2023-2025
Baoding No.1 Central Hospital
2024
Huazhong University of Science and Technology
2016-2021
Central Hospital of Wuhan
2010-2021
Tongji Hospital
2018
Ministry of Ecology and Environment
2017
Guizhou University
2014-2015
First Affiliated Hospital of Kunming Medical University
2015
Kunming Medical University
2015
A series of novel 4-thioquinazoline derivatives containing chalcone moiety were designed, synthesized and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most these compounds exhibited moderate to good anti-TMV activity. In particular, M2 M6 possessed appreciable protection activities TMV in vivo, with 50% effective concentration (EC50) values 138.1 154.8 μg/mL, respectively, which superior Ribavirin (436.0 μg/mL). indicated could...
This study aims to investigate the effects of inhibiting microRNA-9-5p (miR-9-5p) on expression StAR-related lipid transfer domain containing 13 (StarD13) and progress prostate cancer.The mRNA levels miR-9-5p StarD13 were determined in several cancer cell lines. We chose DU145 PC-3 cells for further research. The CCK8 assay was used measure viability. invasion wound-healing assays respectively applied evaluate migration. E-cadherin (E-cad), N-cadherin (N-cad) vimentin measured via western...
A series of novel 3-((2-((1E,4E)-3-oxo-5-arylpenta-1,4-dien-1-yl)phenoxy)methyl)-4(3H)-quinazolinone derivatives were designed and synthesized. Antiviral bioassays indicated that a few the compounds exhibited higher antiviral activities against tobacco mosaic virus (TMV) in vivo than commercial agent ningnanmycin. In particular, A5, A12, A25, A27 possessed appreciable curative bioactivities on TMV vivo, with 50% effective concentration values ranging from 132.25 to 156.10 μg/mL. These are...
// Hongju Yang 1,* , Qian Li 2,* Jie Niu 3,* Bai 2 Dejun Jiang 1 Zhihua Wan Qingmei Fei Ping Wei and Song The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China Human Genetics Center Yunnan 3 Institute Medicinal Biology Chinese Academy Science, * These authors have contributed equally to this work Correspondence to: Bai, email: Keywords : NAA10, miR-342-5p, miR-608, colon cancer Received June 03, 2015 Accepted October 14, Published December 04, Abstract miRNAs...
Studies have demonstrated that oxidaive stress-induced apoptosis may be the main pathogenic mechanism of renal ischemia/reperfusion (I/R) injury. Theaflavin, a polyphenolic compound extracted from black tea, has been proven to exert strong antioxidant biological function. The objective present study was investigate potential role theaflavin on I/R injury and its molecular both in vitro vivo. C57/BL6 J mice were used create model wherein ligated with bilateral pedicles for 45 min, then...
Abstract The purposes of this study were to examine concentrations leptin and biochemical parameters in gestational diabetes mellitus (GDM) patients normal glucose tolerance (NGT) individuals also explore the links ( LEP ) G2548A receptor LEPR Gln223Arg polymorphisms with levels GDM risk among Chinese. Our included 357 355 NGT who at 24~30 weeks. Plasma insulin analyzed by ELISA. Gene genotyped using TaqMan real-time polymerase chain reaction assay. results showed that plasma significantly...
This study aimed to investigate the correlation between M2 macrophages activity with prognosis of lung adenocarcinoma (LUAD). We sought identify key genes associated macrophage and examine their relationship clinicopathological features elucidate underlying mechanism. Published datases were analyzed for differentially expressed genes. After quality control, batch effect removal, annotation, scRNA dataset identified macrophage-associated in LUAD group, which cross-analyzed referred as...
Prostate cancer (PCa) refers to one of the most common tumors in male’s genitourinary system. Emerging research has confirmed that circRNAs play an important role occurrence and development tumors. However, correlation between circular RNA circITGA7 PCa still remains unclear. Here, was explored underlying mechanism investigated as well. The circRNA expression profiles paracancerous tissues were established by high-throughput sequencing. levels cells detected qRT-PCR. Cell Counting Kit-8,...
Type 2 diabetes mellitus (T2DM) is a common cause of erectile dysfunction (ED). It has been demonstrated that G protein-coupled receptor kinase (GRK2) overexpression contributes to diabetic endothelial and oxidative stress, which also underlies ED in T2DM. We hypothesized GRK2 overexpressed attenuated function the cavernosal tissue rat model T2DM rats were established by feeding with high-fat diet (HFD) for weeks then administering two intraperitoneal (IP) injections low dose streptozotocin...
Background: Methods for predicting the outcome of lung adenocarcinoma (LUAD) in clinic are limited. Anoikis is an important route to programmed cell death LUAD, and prognostic value a model constructed with anoikis-related lncRNAs (ARlncRNAs) LUAD unclear. Methods: Transcriptome basic information patients was obtained from Cancer Genome Atlas. Coexpression Cox regression analyses were utilized identify prognostically significant ARlncRNAs construct signature. Furthermore, signature combined...
Background: PANoptosis, a novelty mechanism of cell death involving crosstalk between apoptosis, pyroptosis, and necroptosis, is strongly associated with tumor immunotherapy efficacy. However, its relevance in lung adenocarcinoma (LUAD) remains to be elucidated. Methods: In this study, we acquired 18 PANoptosis-related differentially expressed gene (PRDEG) LUAD. Based on these genes, LUAD samples were identified different sub-types by unsupervised clustering. Next, compared the differences...
Erectile dysfunction (ED) after cavernous nerve (CN) injury remains difficult to treat. Calpain plays a critical role in causing neurodegenerative diseases. This study aimed evaluate whether calpain inhibition preserves erectile function rat model of CN injury.Rats underwent sham surgery or crush injury. The CN-crushed rats were treated with vehicle MDL-28170, specific inhibitor. At 1, 2, 3, and 7 days post-surgery, major pelvic ganglia (MPG) harvested, followed by the measurement function,...
Abstract Objective: Prostate cancer (PCa) refers to one of the most common tumors in male’s genitourinary system. Emerging research has confirmed that circRNAs play an important role occurrence and development tumors. However, correlation between circular RNA circITGA7 PCa still remains unclear. Here, was explored underlying mechanism investigated as well. Methods: The circRNA expression profiles paracancerous tissues were established by high-throughput sequencing. levels cells detected...
Objective To investigate the effects of emodin on apoptosis and expression inducing factor(AIF)and endonuclease G(Endo G)in prostate cancer cells mechanism. Methods The cultured in vitro were divided into 4 groups:blank control group, cysteinyl aspartate-specific protease(Caspase)inhibitor group combined with caspase inhibitor group.Methyl thiazol tetrazolium(MTT)colorimetric assay was used to measure cell viability. The measured by flow cytometry.The AIF Endo G mRNA protents...